EXOC6_RAT
ID EXOC6_RAT Reviewed; 804 AA.
AC O54923;
DT 25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2002, sequence version 2.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Exocyst complex component 6;
DE AltName: Full=Exocyst complex component Sec15A;
DE AltName: Full=SEC15-like protein 1;
DE Short=rSec15;
GN Name=Exoc6; Synonyms=Sec15, Sec15a, Sec15l1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=9405631; DOI=10.1073/pnas.94.26.14438;
RA Kee Y., Yoo J.-S., Hazuka C.D., Peterson K.E., Hsu S.-C., Scheller R.H.;
RT "Subunit structure of the mammalian exocyst complex.";
RL Proc. Natl. Acad. Sci. U.S.A. 94:14438-14443(1997).
RN [2]
RP INTERACTION WITH EXOC8, AND SUBCELLULAR LOCATION.
RX PubMed=12954101; DOI=10.1089/153685903322286575;
RA Wang S., Hsu S.C.;
RT "Immunological characterization of exocyst complex subunits in cell
RT differentiation.";
RL Hybrid. Hybridomics 22:159-164(2003).
RN [3]
RP FUNCTION.
RX PubMed=20890297; DOI=10.1038/ncb2106;
RA Bryant D.M., Datta A., Rodriguez-Fraticelli A.E., Peraenen J.,
RA Martin-Belmonte F., Mostov K.E.;
RT "A molecular network for de novo generation of the apical surface and
RT lumen.";
RL Nat. Cell Biol. 12:1035-1045(2010).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane. Together
CC with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP
CC promotes transcytosis of PODXL to the apical membrane initiation sites
CC (AMIS), apical surface formation and lumenogenesis.
CC {ECO:0000269|PubMed:20890297}.
CC -!- SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4,
CC EXOC5, EXOC6, EXOC7 and EXOC8 (PubMed:12954101). Interacts with CNTRL
CC (By similarity). Interacts with RAB11A in a GTP-dependent manner (By
CC similarity). {ECO:0000250, ECO:0000269|PubMed:12954101}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12954101}.
CC Cytoplasm, perinuclear region {ECO:0000269|PubMed:12954101}. Cell
CC projection, growth cone {ECO:0000269|PubMed:12954101}. Midbody, Midbody
CC ring {ECO:0000250|UniProtKB:Q8TAG9}. Note=Perinuclear in
CC undifferentiated cells. Redistributes to growing neurites and growth
CC cones during neuronal differentiation (PubMed:12954101). Colocalizes
CC with CNTRL/centriolin at the midbody ring (By similarity).
CC {ECO:0000250|UniProtKB:Q8TAG9, ECO:0000269|PubMed:12954101}.
CC -!- SIMILARITY: Belongs to the SEC15 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC01580.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF032668; AAC01580.1; ALT_INIT; mRNA.
DR PIR; T09221; T09221.
DR RefSeq; NP_062150.2; NM_019277.2.
DR AlphaFoldDB; O54923; -.
DR SMR; O54923; -.
DR CORUM; O54923; -.
DR STRING; 10116.ENSRNOP00000051630; -.
DR CarbonylDB; O54923; -.
DR iPTMnet; O54923; -.
DR PhosphoSitePlus; O54923; -.
DR jPOST; O54923; -.
DR PaxDb; O54923; -.
DR PRIDE; O54923; -.
DR GeneID; 50556; -.
DR KEGG; rno:50556; -.
DR CTD; 54536; -.
DR RGD; 3653; Exoc6.
DR eggNOG; KOG2176; Eukaryota.
DR InParanoid; O54923; -.
DR OrthoDB; 185623at2759; -.
DR PhylomeDB; O54923; -.
DR Reactome; R-RNO-264876; Insulin processing.
DR Reactome; R-RNO-5620916; VxPx cargo-targeting to cilium.
DR PRO; PR:O54923; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR GO; GO:0090543; C:Flemming body; IEA:UniProtKB-SubCell.
DR GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030218; P:erythrocyte differentiation; ISO:RGD.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0090522; P:vesicle tethering involved in exocytosis; IEA:InterPro.
DR Gene3D; 1.10.357.30; -; 1.
DR Gene3D; 1.20.58.670; -; 1.
DR InterPro; IPR007225; EXOC6/Sec15.
DR InterPro; IPR042045; EXOC6/Sec15_C_dom1.
DR InterPro; IPR042044; EXOC6PINT-1/Sec15/Tip20_C_dom2.
DR InterPro; IPR046361; Sec15_C.
DR PANTHER; PTHR12702; PTHR12702; 1.
DR Pfam; PF04091; Sec15; 1.
DR PIRSF; PIRSF025007; Sec15; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cytoplasm; Exocytosis; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..804
FT /note="Exocyst complex component 6"
FT /id="PRO_0000118953"
SQ SEQUENCE 804 AA; 93178 MW; 5B6F669290ECB459 CRC64;
MAESGEALGT VPEHERILQE IESTDTACVG PTLRSVYDGQ PNAHKKFMEK LDACIRNHDK
EIEKMCNFHH QGFVDAITEL LKVRADAEKL KVQVTDTNRR FQDAGKEVIE QTEDIIRCRI
QQRNITTVVE KLQLCLPVLE MYSKLKEQMS MQRYYSALKT MEQLENVYFP RVSQYRFCQL
MMDTLPKLRE DIKDISMSDL KDFLESIRKH SDKIGETAMK QAQQQKSFSI AVQKQTNMRF
GKNMHVNNDR TLEEKSDIIL KHTLEEEAEN DEEVLTVQDL VDFSPVYRCS HIYSALGDEE
TFENYYRKQR KKQARLVLQP QSSVHETVDG YRRYFTQIVG FFVVEDHILH VTQGLVTRAY
TDELWNMALS KIIAVLRAHS SYCTDPDLVL ELKNLIVIFA DTLQGYGFSV NRLFDLLFEI
RDQYNETLLK KWAGIFRDIF EEDNYSPIPI GSEEEYKMVI SKFPFQDPDL EKQSFPKKFP
MSQSVPLIYI QVKEFIYASL KFSESLHRSS TEIDDMLRKS TNLLLTRILS SCLLNLIRKP
HIGLTELVQI IINTTHLEQA CKYLEDFITN ITNISQETVH TTRLYGLSTF KDARHAAEGE
IYTKLNQKID EFVQLADYDW TMAESDGRAS GYLMDLINFL RSIFQVFTHL PGKVAQTACM
SACQHLSTSL MQMLLDSELK QISMGAVQQF NLDVIQCELF ASSEPVPGFQ GDTLQLAFID
LRQLLDLFMV WDWSTYLADY GQPASKYLRV NPHAALTLLE KMKDTSKKNN IFAQFRKNDR
DRQKLIETVV KQLRGLVTGM SQHM
