ID   EXOC7_DANRE             Reviewed;         720 AA.
AC   E7FC72;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2016, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Exocyst complex component 7 {ECO:0000312|ZFIN:ZDB-GENE-040426-2752};
GN   Name=exoc7 {ECO:0000312|ZFIN:ZDB-GENE-040426-2752};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   FUNCTION.
RX   PubMed=32103185; DOI=10.1038/s41436-020-0758-9;
RA   Coulter M.E., Musaev D., DeGennaro E.M., Zhang X., Henke K., James K.N.,
RA   Smith R.S., Hill R.S., Partlow J.N., Al-Saffar M., Kamumbu A.S., Hatem N.,
RA   Barkovich A.J., Aziza J., Chassaing N., Zaki M.S., Sultan T., Burglen L.,
RA   Rajab A., Al-Gazali L., Mochida G.H., Harris M.P., Gleeson J.G.,
RA   Walsh C.A.;
RT   "Regulation of human cerebral cortical development by EXOC7 and EXOC8,
RT   components of the exocyst complex, and roles in neural progenitor cell
RT   proliferation and survival.";
RL   Genet. Med. 22:1040-1050(2020).
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane (By
CC       similarity). It is required for neuron survival and plays an essential
CC       role in telencephalon development (PubMed:32103185).
CC       {ECO:0000250|UniProtKB:Q9UPT5, ECO:0000269|PubMed:32103185}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:O35250}. Cell membrane
CC       {ECO:0000250|UniProtKB:O35250}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:O35250}. Midbody, Midbody ring
CC       {ECO:0000250|UniProtKB:Q9UPT5}.
CC   -!- DOMAIN: The C-terminus is required for translocation to the plasma
CC       membrane. {ECO:0000250|UniProtKB:Q9UPT5}.
CC   -!- SIMILARITY: Belongs to the EXO70 family. {ECO:0000305}.
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DR   EMBL; FP102121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_009305253.1; XM_009306978.2.
DR   AlphaFoldDB; E7FC72; -.
DR   SMR; E7FC72; -.
DR   STRING; 7955.ENSDARP00000106414; -.
DR   PaxDb; E7FC72; -.
DR   PeptideAtlas; E7FC72; -.
DR   Ensembl; ENSDART00000123834; ENSDARP00000106414; ENSDARG00000087229.
DR   ZFIN; ZDB-GENE-040426-2752; exoc7.
DR   eggNOG; KOG2344; Eukaryota.
DR   GeneTree; ENSGT00390000003595; -.
DR   InParanoid; E7FC72; -.
DR   TreeFam; TF324243; -.
DR   Reactome; R-DRE-264876; Insulin processing.
DR   Reactome; R-DRE-5620916; VxPx cargo-targeting to cilium.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 12.
DR   Bgee; ENSDARG00000087229; Expressed in testis and 28 other tissues.
DR   ExpressionAtlas; E7FC72; baseline.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0090543; C:Flemming body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR004140; Exo70.
DR   InterPro; IPR046364; Exo70_C.
DR   PANTHER; PTHR12542; PTHR12542; 1.
DR   Pfam; PF03081; Exo70; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Coiled coil; Cytoplasm; Exocytosis; Membrane;
KW   Phosphoprotein; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..720
FT                   /note="Exocyst complex component 7"
FT                   /id="PRO_0000453462"
FT   REGION          249..268
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          5..34
FT                   /evidence="ECO:0000255"
FT   COILED          63..83
FT                   /evidence="ECO:0000255"
FT   MOD_RES         133
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O54922"
SQ   SEQUENCE   720 AA;  82197 MW;  8DFCA720F0A5FC3C CRC64;
     MIPTEDASAR KREIEEKLKQ EQETLSFIRE SLEKSDQLTK GMVSILSSFE SRLMQLENSI
     IPVHKQTENL QRLQENVDKT LSNMDHVISY YHVAKDTDKI IREGPAGRLY EYLACIAKIQ
     KAVEYFQDNN PDSPELNTVK ARFEKGKELL EAEFRSLLTR YSKPVPPVLI LDAIGGDEDM
     EVQEEVTLEH LPEAVLQDII CISAWLVEYG RNQDFMNVYF QVRSSQLDRS IKGLKEHFRK
     NSATSAIHSP AVQTKRKETP TKKAPKRPVY IPGTIRKAQN LLKQYSQHGL DGKKGSNLTP
     LEGFEHDLRG VKHLSDEKHG ATAGKDDVLD IEIDSYIHCI SAFVKLAQSE YALLTEIIPE
     HHQKKTFDSL IQEALDNLML EGDNIVSAAR RAIMRHDYSA VLTIFPILRH LKQTKPDFDA
     TLQGTAASTK NKLPALITSM ETIGAKALEE FADSIKNDPD KEYNMPKDGT VHELTSNAIL
     FLQQLLDFQE TAGAMLASQV LGDTYNIPLD PRESSSSASS YSSEFSRKLL STYIYKVLGN
     LQLNLSNKAK VYEDPALRAI FLHNNYNYIL KSLEKSELIQ LVAVTVKKVE SSYRELIEQE
     IQNYQRSWLR VTEHLAERNI PDFQPGAKLK DKERQIIKDK FKGFNDGLEE LCKIQKGWAV
     PDKEQRDTIR HAQKRVVSLT YKAFLQRCAN ISFTKNPEKY HRYSPEQVED MIDRLFDTSA