EXOC7_DICDI
ID EXOC7_DICDI Reviewed; 840 AA.
AC Q558Z9; Q86IF4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Exocyst complex component 7;
DE AltName: Full=Exocyst complex component Exo70;
GN Name=exoc7; Synonyms=exo70; ORFNames=DDB_G0272991;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC exocytic vesicles with fusion sites on the plasma membrane.
CC {ECO:0000250}.
CC -!- SUBUNIT: The exocyst complex is composed of sec3/exoc1, sec5/exoc2,
CC sec6/exoc3, sec8/exoc4, sec10/exoc5, sec15/exoc6, exo70/exoc7 and
CC exo84/exoc8. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:O35250}. Cell membrane
CC {ECO:0000250|UniProtKB:O35250}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:O35250}. Midbody, Midbody ring
CC {ECO:0000250|UniProtKB:Q9UPT5}.
CC -!- SIMILARITY: Belongs to the EXO70 family. {ECO:0000305}.
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DR EMBL; AAFI02000008; EAL71133.1; -; Genomic_DNA.
DR RefSeq; XP_644917.1; XM_639825.1.
DR AlphaFoldDB; Q558Z9; -.
DR SMR; Q558Z9; -.
DR STRING; 44689.DDB0233927; -.
DR PaxDb; Q558Z9; -.
DR EnsemblProtists; EAL71133; EAL71133; DDB_G0272991.
DR GeneID; 8618596; -.
DR KEGG; ddi:DDB_G0272991; -.
DR dictyBase; DDB_G0272991; exoc7.
DR eggNOG; KOG2344; Eukaryota.
DR HOGENOM; CLU_338721_0_0_1; -.
DR InParanoid; Q558Z9; -.
DR OMA; FAVIFEN; -.
DR PhylomeDB; Q558Z9; -.
DR Reactome; R-DDI-264876; Insulin processing.
DR PRO; PR:Q558Z9; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0000145; C:exocyst; IDA:dictyBase.
DR GO; GO:0090543; C:Flemming body; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IEA:InterPro.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR InterPro; IPR004140; Exo70.
DR InterPro; IPR046364; Exo70_C.
DR PANTHER; PTHR12542; PTHR12542; 1.
DR Pfam; PF03081; Exo70; 1.
DR SUPFAM; SSF74788; SSF74788; 1.
PE 3: Inferred from homology;
KW Cell membrane; Coiled coil; Cytoplasm; Exocytosis; Membrane;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..840
FT /note="Exocyst complex component 7"
FT /id="PRO_0000329040"
FT REGION 1..112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 193..227
FT /evidence="ECO:0000255"
FT COMPBIAS 13..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 840 AA; 94447 MW; D1C295719A46DCBC CRC64;
MSAPPRLSAR LSVLDQKKSN APSPTSPTGL KTSLGMPPNS GSSGGGGGLK SSVGISSLPT
IPSTKSTSPT LPKRNSANLS LLQQQQQQHT NKSTSPSSNT PTATSTTSPF SYLGKQASAQ
NLNTMMSMMM LNKNPLSPVV PQPGASLFYA TPTEADDEEF EHIRNLLNSE YSVTTVQSTG
ALKSSNLVVM SWKNNATSEL TEQDDQLEND KRDLQFIKEQ LEKNNSMSKQ MIYILDRFNE
GLSQLEMDVA PINASMNEWS SIFNNINSTM EQVKSVLDKF DVDKIDSKIN DGAKGDYVSY
MLALEHVGNA IDYIAEKSHF KSSDKVMDAL KQLKATGLNE LETSFKSLLL KISNLVDPTT
IAKLPNSKRY LAIILPNHVE EISKYIELFE KLHYNAFLKE YKDKRSKFIL LSLRKMAPEK
FIKQTSETKN LAYVKGSHPL ISYVQETLRL YQIEYDLASE LFGNQYQLIL DEIIDPAHEL
LLETTEPIIK VRKTPGDKIF SIFPLLDLFD TFTKLLPDFI TAISSRDGKH ISELKTQIKH
LQDTCASLLD FSLDEEKEIS SSNRKEIISD ATVDEISSNM INYFKRLIEY KHSVELLLKG
QDNNNSNSNS NAPSSTSSNS KSSSSSSSSS SSNSASSTIL PTSFIGFLEK ILKNLIKYLQ
GRAKKDFPTQ PATDFFKPPI KSVIFQINNY HYISTSLKQS KILSNQQFEN NELASANHIL
HEFETCLDNE IKVLNSFWKT IADILITNKS NKEKDEVKSI IKKHTNFLKT FNDLNKLKFD
IPDQELKLKL KTEAKNIIGR SYDQFKELCR LEKIHLEKNF VPFETTDDIN RKLDRVFDSQ
