ID   EXOC8_BOVIN             Reviewed;         725 AA.
AC   A4IF89;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Exocyst complex component 8;
GN   Name=EXOC8;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4,
CC       EXOC5, EXOC6, EXOC7 and EXOC8 (By similarity). Interacts (via PH
CC       domain) with GTP-bound RALA and RALB (By similarity). Interacts with
CC       SH3BP1; required for the localization of both SH3BP1 and the exocyst to
CC       the leading edge of migrating cells (By similarity).
CC       {ECO:0000250|UniProtKB:O54924, ECO:0000250|UniProtKB:Q8IYI6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54924}.
CC       Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54924}. Cell
CC       projection, growth cone {ECO:0000250|UniProtKB:O54924}. Cell projection
CC       {ECO:0000250|UniProtKB:O54924}. Note=Binds lipids with
CC       phosphatidylinositol 3,4,5-trisphosphate groups (By similarity).
CC       Perinuclear in undifferentiated PC12 cells. Redistributes to growing
CC       neurites and growth cones during NGF-induced neuronal differentiation
CC       (By similarity). Localizes at the leading edge of migrating cells (By
CC       similarity). {ECO:0000250, ECO:0000250|UniProtKB:O54924}.
CC   -!- SIMILARITY: Belongs to the EXO84 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC134458; AAI34459.1; -; mRNA.
DR   RefSeq; NP_001091581.1; NM_001098112.2.
DR   AlphaFoldDB; A4IF89; -.
DR   STRING; 9913.ENSBTAP00000008028; -.
DR   PaxDb; A4IF89; -.
DR   PRIDE; A4IF89; -.
DR   Ensembl; ENSBTAT00000008028; ENSBTAP00000008028; ENSBTAG00000006111.
DR   GeneID; 540237; -.
DR   KEGG; bta:540237; -.
DR   CTD; 149371; -.
DR   VEuPathDB; HostDB:ENSBTAG00000006111; -.
DR   VGNC; VGNC:28653; EXOC8.
DR   eggNOG; KOG2215; Eukaryota.
DR   GeneTree; ENSGT00390000015936; -.
DR   HOGENOM; CLU_025760_0_0_1; -.
DR   InParanoid; A4IF89; -.
DR   OMA; SACVKWA; -.
DR   OrthoDB; 1357584at2759; -.
DR   TreeFam; TF105819; -.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000006111; Expressed in neutrophil and 107 other tissues.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0005770; C:late endosome; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR   GO; GO:0007032; P:endosome organization; IEA:Ensembl.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0022617; P:extracellular matrix disassembly; IEA:Ensembl.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1210; -; 1.
DR   Gene3D; 1.20.58.1220; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR033961; Exo84.
DR   InterPro; IPR032403; Exo84_C.
DR   InterPro; IPR042561; Exo84_C_1.
DR   InterPro; IPR042560; Exo84_C_2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21426; PTHR21426; 1.
DR   Pfam; PF16528; Exo84_C; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Exocytosis; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..725
FT                   /note="Exocyst complex component 8"
FT                   /id="PRO_0000329045"
FT   DOMAIN          182..282
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          116..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..322
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         19
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IYI6"
SQ   SEQUENCE   725 AA;  81840 MW;  BA00D9BBB0985A1D CRC64;
     MAMAMSDSGA SRLRRQLESG GFEARLYVKQ LSQQSDGDRD LQEHRQRIQA LAEETAQNLK
     RNVYQNYRQF IETAREISYL ESEMYQLSHL LTEQKSSLES IPLTLLPAAA AAGAAAASGG
     EEGGGGAGGR DQLRGQTGFF PSPGGASRDG SGPGEEGKQR TLTTLLEKVE GCRHLLETPG
     QYLVYNGDLV EYEADHMAQL QRVHGFLMND CLLVATWLPQ RRGMYRYNAL YPLDGLAVVN
     VKDNPPMKDM FKLLMFPESR IFQAENAKIK REWLEVLEET KRALSEKRRR EQEEAAAPRG
     PPQVTPKASN PFEDEDDDEP TVPEIEEEKV DLSMEWIQEL PEDLDVCIAQ RDFEGAVDLL
     DKLNHYLEDK PSPPPVKELR ARVDERVRQL TEVLVFELSP DRSLRGGPKA TRRAVSQLIR
     LGQCTKACEL FLRNRAAAVH TAIRQLRIEG ATLLYIHKLC HVFFTSLLET AREFETDFAG
     TDSGCYSAFV VWARSAMGMF VDAFSKQVFD SKESLSTAAE CVRVAKEHCQ QLGDIGLDLT
     FIVHALLVKD IQGALHSYKE IIIEATKHRN SEEMWRRMNL MTPEALGKLK EEMKSCGVSN
     FEQYTGDDCW VNLSYTVVAF TKQTMGFLEE ALKLYFPELH MVLLESLVEI ILVAVQHVDY
     SLRCEQDPEK KAFIRQNASF LYETVLPVVE KRFEEGVGKP AKQLQDLRNA SRLIRVNPES
     TTSVV