ID   EXOC8_CHICK             Reviewed;         708 AA.
AC   Q5ZJ43;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Exocyst complex component 8;
GN   Name=EXOC8; ORFNames=RCJMB04_20o3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4,
CC       EXOC5, EXOC6, EXOC7 and EXOC8. {ECO:0000250|UniProtKB:O54924}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54924}.
CC       Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54924}. Cell
CC       projection, growth cone {ECO:0000250|UniProtKB:O54924}. Cell projection
CC       {ECO:0000250|UniProtKB:O54924}.
CC   -!- SIMILARITY: Belongs to the EXO84 family. {ECO:0000305}.
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DR   EMBL; AJ720591; CAG32250.1; -; mRNA.
DR   RefSeq; NP_001006404.1; NM_001006404.1.
DR   AlphaFoldDB; Q5ZJ43; -.
DR   SMR; Q5ZJ43; -.
DR   STRING; 9031.ENSGALP00000018004; -.
DR   PaxDb; Q5ZJ43; -.
DR   GeneID; 421531; -.
DR   KEGG; gga:421531; -.
DR   CTD; 149371; -.
DR   VEuPathDB; HostDB:geneid_421531; -.
DR   eggNOG; KOG2215; Eukaryota.
DR   HOGENOM; CLU_025760_0_0_1; -.
DR   InParanoid; Q5ZJ43; -.
DR   OrthoDB; 1357584at2759; -.
DR   PhylomeDB; Q5ZJ43; -.
DR   PRO; PR:Q5ZJ43; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1210; -; 1.
DR   Gene3D; 1.20.58.1220; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR033961; Exo84.
DR   InterPro; IPR032403; Exo84_C.
DR   InterPro; IPR042561; Exo84_C_1.
DR   InterPro; IPR042560; Exo84_C_2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21426; PTHR21426; 1.
DR   Pfam; PF16528; Exo84_C; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Exocytosis; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..708
FT                   /note="Exocyst complex component 8"
FT                   /id="PRO_0000227553"
FT   DOMAIN          168..268
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          271..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        295..314
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   708 AA;  80430 MW;  8BAFACDD85BD2D21 CRC64;
     MALALGEGGG GSRLRRQLES GGFAAAEYVK QLSQQSDGDR DLQEHRQRIQ ALQEETAQSL
     KRNVYQNYRQ FIETAREISY LESEMYQLSH ILTEQKGIME AVTQALLLQA DRDDPALGAR
     RAAAADPFLP LSAKEAAASE EGRQRTLTTL LEKVEGCRDL LPESPGKYLV YNGDLLEYDA
     DHMAQIQRVH AFLMNDCLLV ATALPNRRGA YRYDALYPLE GLAVVNVKDN PPMKDMFKLL
     MFPESRIFQA ENAKIKKEWL EVLEETKRNR ALSEKRRLEQ EALPRPAPTP PESTNPFEEE
     EEEEEEPSAE EEAVDLSLEW IQELPEDLDV CIAQRDFEGA VDLLDKLNEY LADKPVSQPV
     KELRAKVDER VRQLTDVLVF ELSPDRSLRG GPRATRRAVS QLIRLGQSTK ACELFLKNRA
     AAVHTAIRQL RIEGATLLYI HKLCHVFFTS LLETAREFET DFAGNNGCYS AFVVWARSSM
     RMFVDAFSKQ VFDSKESLST AAECVKVAKE HCKQLSDIGL DLTFIIHALL VKDIKGALQS
     YKDIIIEATK HRNSEEMWRR MNLMTPEALG KLREEMKSCG VGSFDQYTGD DCWVNLSYTV
     VAFTKQTMAF LEEALKLYFP ELHMVLLESL VEIILVAVQH VDYSLRCEQD PEKKAFIRQN
     ASFLYETVLP VVEKRFEEGV GKPAKQLQDL RNASRLMRIN PESTTSVV