ID   EXOC8_DICDI             Reviewed;         815 AA.
AC   Q54VZ8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 2.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Exocyst complex component 8;
DE   AltName: Full=Exocyst complex component Exo84;
GN   Name=exoc8; Synonyms=exo84; ORFNames=DDB_G0279991;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The exocyst complex is composed of sec3/exoc1, sec5/exoc2,
CC       sec6/exoc3, sec8/exoc4, sec10/exoc5, sec15/exoc6, exo70/exoc7 and
CC       exo84/exoc8. {ECO:0000250|UniProtKB:O54924}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54924}.
CC       Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54924}. Cell
CC       projection {ECO:0000250|UniProtKB:O54924}.
CC   -!- SIMILARITY: Belongs to the EXO84 family. {ECO:0000305}.
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DR   EMBL; AAFI02000035; EAL67467.2; -; Genomic_DNA.
DR   RefSeq; XP_641452.2; XM_636360.2.
DR   AlphaFoldDB; Q54VZ8; -.
DR   SMR; Q54VZ8; -.
DR   STRING; 44689.DDB0233971; -.
DR   PaxDb; Q54VZ8; -.
DR   PRIDE; Q54VZ8; -.
DR   EnsemblProtists; EAL67467; EAL67467; DDB_G0279991.
DR   GeneID; 8622337; -.
DR   KEGG; ddi:DDB_G0279991; -.
DR   dictyBase; DDB_G0279991; exoc8.
DR   eggNOG; KOG2215; Eukaryota.
DR   HOGENOM; CLU_346636_0_0_1; -.
DR   InParanoid; Q54VZ8; -.
DR   OMA; TMDDITK; -.
DR   Reactome; R-DDI-264876; Insulin processing.
DR   PRO; PR:Q54VZ8; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0000145; C:exocyst; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006893; P:Golgi to plasma membrane transport; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1210; -; 1.
DR   Gene3D; 1.20.58.1220; -; 1.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR033961; Exo84.
DR   InterPro; IPR032403; Exo84_C.
DR   InterPro; IPR042561; Exo84_C_1.
DR   InterPro; IPR042560; Exo84_C_2.
DR   PANTHER; PTHR21426; PTHR21426; 1.
DR   Pfam; PF16528; Exo84_C; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cytoplasm; Exocytosis; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..815
FT                   /note="Exocyst complex component 8"
FT                   /id="PRO_0000329044"
FT   REGION          479..511
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  93524 MW;  DDBE3B92242901D1 CRC64;
     MKKGVTYPLK IDTNLSTVSS SVNYNDIECV DIKSNGHYIV KFMYREWVGP LNLMTTQKTS
     IKISIDLKEQ TVTCTHTDKK KTVYRWGEFP NKKETEQNKK EDNPVQYETF LSSNFNSEKY
     VNDLFTHKTD QQATVHLQYL ENRKLGCIDH LKKDVYKNHL IFIGASKEIA NSEVDMLDFR
     NLISDYGNVM SSLQNISISW DHYKVKKSGK IDFEPLSPAT EPIQWLTTAP NELSVSIEQR
     EFEVAVGLVE KINKIYESNP KVEIVMQTHP LKDQIENKVK ILTDKLMNEL RSPLLKANQI
     KDTISLLVRL SQNDKAKSIF LESRSHSINQ AIKKIVFSGD LNRFIGELAR VIFNSINSTC
     NDFTNSFPSY MNSGLVSWII EELVLISDIF NRQVFILDNF YSISQAIRII ESHCEMMDQT
     GLSIGFYWNL LLQPHVEQLI VNYEIKIRDS MLHQLMDEKW NGVSNWDYEV KSQLNSLPSS
     LKNSGTPNSG GSGISNNNSN NNNNYQSPII NNNFNSGGGN KKIGLTFQQM HQDNLNNMED
     IDQGRLKLTS STIFLNTIIQ KFAIDICQII TIDLIPVISQ SLGSIFKDYM SYLKNEIQKE
     YLSDTQCLAI ISDSVYIVDD LVSRIATRFE DATGEKLNNL TQLSSLLYSY FESIRDQYST
     RKALELVDNS MNWEEQEYQV EEELDPFPKN FIVLSEALDR LAESIQTNVN VESVLPIASR
     IISEIVNIIS NRFESTSNLV FGYGGLQHFI LEMKYLATFA GKYPVEDSTF ELINTMIRNH
     KEIYLNNTSD PKPLKTEEYF TSIIDNLVYQ KAVYN