ID   EXOC8_XENLA             Reviewed;         685 AA.
AC   Q5U247;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Exocyst complex component 8;
GN   Name=exoc8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the exocyst complex involved in the docking of
CC       exocytic vesicles with fusion sites on the plasma membrane.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The exocyst complex is composed of exoc1, exoc2, exoc3, exoc4,
CC       exoc5, exoc6, exoc7 and exoc8. {ECO:0000250|UniProtKB:O54924}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O54924}.
CC       Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O54924}. Cell
CC       projection, growth cone {ECO:0000250|UniProtKB:O54924}. Cell projection
CC       {ECO:0000250|UniProtKB:O54924}.
CC   -!- SIMILARITY: Belongs to the EXO84 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC086283; AAH86283.1; -; mRNA.
DR   RefSeq; NP_001090265.1; NM_001096796.1.
DR   AlphaFoldDB; Q5U247; -.
DR   SMR; Q5U247; -.
DR   MaxQB; Q5U247; -.
DR   PRIDE; Q5U247; -.
DR   DNASU; 779171; -.
DR   GeneID; 779171; -.
DR   KEGG; xla:779171; -.
DR   CTD; 779171; -.
DR   Xenbase; XB-GENE-995735; exoc8.S.
DR   OMA; SACVKWA; -.
DR   OrthoDB; 1357584at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 779171; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0000145; C:exocyst; IEA:InterPro.
DR   GO; GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1210; -; 1.
DR   Gene3D; 1.20.58.1220; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR033961; Exo84.
DR   InterPro; IPR032403; Exo84_C.
DR   InterPro; IPR042561; Exo84_C_1.
DR   InterPro; IPR042560; Exo84_C_2.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR21426; PTHR21426; 1.
DR   Pfam; PF16528; Exo84_C; 1.
DR   SMART; SM00233; PH; 1.
DR   SUPFAM; SSF74788; SSF74788; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cytoplasm; Exocytosis; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..685
FT                   /note="Exocyst complex component 8"
FT                   /id="PRO_0000227554"
FT   DOMAIN          151..251
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   REGION          254..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   685 AA;  78774 MW;  21E2C3ECF3614790 CRC64;
     MAEGGGSVQR LRRQLESNSF QAEQYVKLLS QQSDGDRDLQ EHRQRIQSLA DETAQSLKRN
     VYQNYRQFIE TAKEISYLEG EMYQLSHILT EQKSIMESVT QALLYTDRSE AARELQTAFP
     KEAEEGKVRN LTTLLEKVEG CKNLLETPGR YLVYNGDLTE FDVDNMALIQ KVHAFLMNDC
     LLIATSVPNR RGIYKYNALH NLDDLAVVNV KENPPMKDMF KILMFPESRI FQAENAKIKK
     EWLEILEQTK KNKALNEKQK QEETTPQLPV VPEIPANPFI DEDGTFDEVE VDLTIDWIQE
     LPEDLDVCIA QRNFEGAVDL LDKLNSYLED KPLTHPVKEL KSKVDERVRQ LTDVLVFELS
     PDRSLRGGPK ATRRAVSQLV RLGQSTKACE LFLKNQAAAV QTAIRQLRIE GATLLYIHKL
     CNVFFTSLLE TAKEFEMDFA ENHGCYSAFI VWSRLALKMF VDAFSKQVFD SKESLSTVAE
     CVKVAKEHCK QLSEIGLDLT FILHTLLVKD IKAALQSYKD IVIEATKHRN SEEMWRRMNL
     MTPEVLGKLR EEMRNCGINN FDQYTGDDCW VNISYTIVAF TKQTMAFLEE ALKLYFPELH
     MVLLECLMEI ILVAIQHVDY SLRCEQESEK KAFIRQNASF LYENVLVVVE KRFEEGVGKP
     AKQLQELRNS SRLVRVNPES TTSVV