ID   EXOD_RHIME              Reviewed;         240 AA.
AC   Q52923;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Protein ExoD;
GN   Name=exoD; OrderedLocusNames=R00273; ORFNames=SMc00353;
OS   Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS   meliloti).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX   NCBI_TaxID=266834;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=1748284; DOI=10.1101/gad.5.12a.2274;
RA   Reed J.W., Walker G.C.;
RT   "Acidic conditions permit effective nodulation of alfalfa by invasion-
RT   deficient Rhizobium meliloti exoD mutants.";
RL   Genes Dev. 5:2274-2287(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11481430; DOI=10.1073/pnas.161294398;
RA   Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA   Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA   Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA   Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA   Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT   "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT   meliloti strain 1021.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1021;
RX   PubMed=11474104; DOI=10.1126/science.1060966;
RA   Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA   Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA   Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA   Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA   Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA   Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA   Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA   Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA   Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA   Wong K., Yeh K.-C., Batut J.;
RT   "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL   Science 293:668-672(2001).
CC   -!- FUNCTION: Required for nodule invasion. Mutations in this gene lead to
CC       sensitivity to alkaline conditions which prevents nodule invasion.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: To Synechocystis PCC 6803 slr1875. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1, Met-18 or Met-29 is the
CC       initiator. {ECO:0000305}.
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DR   EMBL; M61753; AAA26259.1; -; Genomic_DNA.
DR   EMBL; AL591688; CAC41710.1; -; Genomic_DNA.
DR   PIR; A39480; A39480.
DR   RefSeq; NP_384379.1; NC_003047.1.
DR   RefSeq; WP_004435516.1; NC_003047.1.
DR   AlphaFoldDB; Q52923; -.
DR   STRING; 266834.SMc00353; -.
DR   EnsemblBacteria; CAC41710; CAC41710; SMc00353.
DR   GeneID; 61601754; -.
DR   KEGG; sme:SMc00353; -.
DR   PATRIC; fig|266834.11.peg.1641; -.
DR   eggNOG; COG3932; Bacteria.
DR   HOGENOM; CLU_093444_0_1_5; -.
DR   OMA; WRINGFC; -.
DR   Proteomes; UP000001976; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010331; ExoD.
DR   PANTHER; PTHR41795; PTHR41795; 1.
DR   Pfam; PF06055; ExoD; 1.
DR   PIRSF; PIRSF033239; ExoD; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Nodulation; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..240
FT                   /note="Protein ExoD"
FT                   /id="PRO_0000087123"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..223
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   240 AA;  26040 MW;  F191976767CF4F84 CRC64;
     MVCQARFGVK NASRGHRMER PQTVKGKIMA VEFGDSQRSL SDTLTGMIAS IRGNTITLRE
     LMIEIGEQGF LLLCALLTLP FLIPVSIPGV STVFGAAIIL ISLAITLNRM PWLPKRILDR
     EIATEKLVPT LRKGAALVSK LDRYVRPRLN FLTEGALMNR FNGLMIMAGG VLLMFPLGLI
     PLSNTLPGIA ILLLSLGIIQ RDGLMVAGGY FFLVATTVYF AVLGYAAFAA GQGLSHFFVS