ID   EXOS2_BOVIN             Reviewed;         293 AA.
AC   Q2KID0;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Exosome complex component RRP4;
DE   AltName: Full=Exosome component 2;
DE   AltName: Full=Ribosomal RNA-processing protein 4;
GN   Name=EXOSC2; Synonyms=RRP4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-catalytic component of the RNA exosome complex which has
CC       3'->5' exoribonuclease activity and participates in a multitude of
CC       cellular RNA processing and degradation events. In the nucleus, the RNA
CC       exosome complex is involved in proper maturation of stable RNA species
CC       such as rRNA, snRNA and snoRNA, in the elimination of RNA processing
CC       by-products and non-coding 'pervasive' transcripts, such as antisense
CC       RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs
CC       with processing defects, thereby limiting or excluding their export to
CC       the cytoplasm. The RNA exosome may be involved in Ig class switch
CC       recombination (CSR) and/or Ig variable region somatic hypermutation
CC       (SHM) by targeting AICDA deamination activity to transcribed dsDNA
CC       substrates. In the cytoplasm, the RNA exosome complex is involved in
CC       general mRNA turnover and specifically degrades inherently unstable
CC       mRNAs containing AU-rich elements (AREs) within their 3' untranslated
CC       regions, and in RNA surveillance pathways, preventing translation of
CC       aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
CC       The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9)
CC       is proposed to play a pivotal role in the binding and presentation of
CC       RNA for ribonucleolysis, and to serve as a scaffold for the association
CC       with catalytic subunits and accessory proteins or complexes. EXOSC2 as
CC       peripheral part of the Exo-9 complex stabilizes the hexameric ring of
CC       RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA exosome complex. Specifically part of the
CC       catalytically inactive RNA exosome core (Exo-9) complex which is
CC       believed to associate with catalytic subunits EXOSC10, and DIS3 or
CC       DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.
CC       Exo-9 is formed by a hexameric ring of RNase PH domain-containing
CC       subunits specifically containing the heterodimers EXOSC4-EXOSC9,
CC       EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing
CC       components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring
CC       structure. Interacts with DIS3. Interacts with GTPBP1. Interacts with
CC       ZFP36L1 (via N-terminus). {ECO:0000250|UniProtKB:Q13868}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RRP4 family. {ECO:0000305}.
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DR   EMBL; BC112683; AAI12684.1; -; mRNA.
DR   RefSeq; NP_001040026.1; NM_001046561.2.
DR   AlphaFoldDB; Q2KID0; -.
DR   SMR; Q2KID0; -.
DR   STRING; 9913.ENSBTAP00000053924; -.
DR   PaxDb; Q2KID0; -.
DR   PRIDE; Q2KID0; -.
DR   Ensembl; ENSBTAT00000072388; ENSBTAP00000070411; ENSBTAG00000048071.
DR   GeneID; 615712; -.
DR   KEGG; bta:615712; -.
DR   CTD; 23404; -.
DR   VEuPathDB; HostDB:ENSBTAG00000048071; -.
DR   VGNC; VGNC:28657; EXOSC2.
DR   eggNOG; KOG3013; Eukaryota.
DR   GeneTree; ENSGT00940000153596; -.
DR   HOGENOM; CLU_034114_3_1_1; -.
DR   InParanoid; Q2KID0; -.
DR   OMA; GVNGFIW; -.
DR   OrthoDB; 1121868at2759; -.
DR   TreeFam; TF105623; -.
DR   Proteomes; UP000009136; Chromosome 11.
DR   Bgee; ENSBTAG00000048071; Expressed in caput epididymis and 108 other tissues.
DR   ExpressionAtlas; Q2KID0; baseline and differential.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0031090; C:organelle membrane; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0071034; P:CUT catabolic process; IBA:GO_Central.
DR   GO; GO:0043928; P:exonucleolytic catabolism of deadenylated mRNA; IBA:GO_Central.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0034427; P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; IBA:GO_Central.
DR   GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IBA:GO_Central.
DR   GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR   GO; GO:0034475; P:U4 snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 2.40.50.140; -; 1.
DR   InterPro; IPR025721; Exosome_cplx_N_dom.
DR   InterPro; IPR026699; Exosome_RNA_bind1/RRP40/RRP4.
DR   InterPro; IPR004088; KH_dom_type_1.
DR   InterPro; IPR036612; KH_dom_type_1_sf.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR21321; PTHR21321; 1.
DR   Pfam; PF14382; ECR1_N; 1.
DR   Pfam; PF15985; KH_6; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF54791; SSF54791; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Exosome; Nucleus; Phosphoprotein; Reference proteome;
KW   RNA-binding; rRNA processing.
FT   CHAIN           1..293
FT                   /note="Exosome complex component RRP4"
FT                   /id="PRO_0000287528"
FT   DOMAIN          79..159
FT                   /note="S1 motif"
FT   MOD_RES         124
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13868"
SQ   SEQUENCE   293 AA;  32649 MW;  4F801091D5D10281 CRC64;
     MALEMRLPVA RKPLSESLGR ESKKHLVVPG DTITTDTGFM RGHGTYMGEE KLIASVAGSV
     ERVNKLICVK ALKTRYNGEV GDIVVGRITE VQQKRWKVET NSRLDSVLLL SSMNLPGGEL
     RRRSAEDELA MRGFLQEGDL ISAEVQAVFS DGAVSLHTRS LKYGKLGQGV LVQVSPSLVK
     RQKTHFHDLP CGASVILGNN GFIWVYPTPE HKEDDAGGFI ANLEPVSLTD REVISRLRNC
     IVSLATQRMM LYDTSILYCY EASLPHQIKD ILKPEIMEEI VMETRQRLLE QEG