ID   EXOS4_CAEBR             Reviewed;         240 AA.
AC   A8WQQ5; H8WH59;
DT   23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Putative exosome complex component RRP41;
GN   Name=exos-4.1; ORFNames=CBG01825;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Non-catalytic component of the RNA exosome complex which has
CC       3'->5' exoribonuclease activity and participates in a multitude of
CC       cellular RNA processing and degradation events. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA exosome complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NPD3}.
CC       Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NPD3}. Nucleus
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. {ECO:0000255}.
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DR   EMBL; HE601298; CCG58551.1; -; Genomic_DNA.
DR   RefSeq; XP_002634254.1; XM_002634208.1.
DR   AlphaFoldDB; A8WQQ5; -.
DR   SMR; A8WQQ5; -.
DR   STRING; 6238.CBG01825a; -.
DR   EnsemblMetazoa; CBG01825.1; CBG01825.1; WBGene00025010.
DR   GeneID; 8576249; -.
DR   KEGG; cbr:CBG_01825; -.
DR   CTD; 8576249; -.
DR   WormBase; CBG01825; CBP00395; WBGene00025010; Cbr-exos-4.1.
DR   eggNOG; KOG1068; Eukaryota.
DR   HOGENOM; CLU_063514_0_0_1; -.
DR   InParanoid; A8WQQ5; -.
DR   OMA; GIAMYDY; -.
DR   OrthoDB; 1394468at2759; -.
DR   Proteomes; UP000008549; Chromosome IV.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0071028; P:nuclear mRNA surveillance; IBA:GO_Central.
DR   GO; GO:0034427; P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; IBA:GO_Central.
DR   GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IBA:GO_Central.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0034475; P:U4 snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.30.230.70; -; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR018336; RNase_PH_CS.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
DR   PROSITE; PS01277; RIBONUCLEASE_PH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exosome; Nucleus; Reference proteome; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..240
FT                   /note="Putative exosome complex component RRP41"
FT                   /id="PRO_0000351213"
SQ   SEQUENCE   240 AA;  26183 MW;  98FC98E0DC366530 CRC64;
     MSIISEHGFR MDGRRPAQIR NINTRLGLNR NAEGSCYLEH GNTKVLCAVY GPYESKASKR
     LEDRCAIVCQ YSTTTFSGLE RKNRPRGDRK STEISRLLEK AFESVILTES FPRSQIDIFC
     EVIQGDGSNL AACVNATSLA LADAGIPMKG IASAATCGIV ETKPIVDLTS REETDLLPRV
     TLATICGRDE VILVELQNRL HIDHLSVVMD AAKATCADVY ECLAVVAQQH LKACAPILGN