ID   EXOS4_CAEEL             Reviewed;         240 AA.
AC   Q17533;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Putative exosome complex component RRP41;
DE   AltName: Full=Ribosomal RNA-processing protein 41;
GN   Name=exos-4.1; ORFNames=B0564.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Non-catalytic component of the RNA exosome complex which has
CC       3'->5' exoribonuclease activity and participates in a multitude of
CC       cellular RNA processing and degradation events. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA exosome complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: Exos-4.1 and tin-9.2 are transcribed on a dicistronic
CC       transcript where exos-4.1 is the upstream transcript and tin-9.2 the
CC       downstream.
CC   -!- SIMILARITY: Belongs to the RNase PH family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z73422; CAA97771.3; -; Genomic_DNA.
DR   PIR; B88880; B88880.
DR   RefSeq; NP_001021274.1; NM_001026103.6.
DR   AlphaFoldDB; Q17533; -.
DR   SMR; Q17533; -.
DR   STRING; 6239.B0564.1a; -.
DR   EPD; Q17533; -.
DR   PaxDb; Q17533; -.
DR   PeptideAtlas; Q17533; -.
DR   EnsemblMetazoa; B0564.1a.1; B0564.1a.1; WBGene00007201.
DR   EnsemblMetazoa; B0564.1a.2; B0564.1a.2; WBGene00007201.
DR   EnsemblMetazoa; B0564.1a.3; B0564.1a.3; WBGene00007201.
DR   WormBase; B0564.1a; CE20469; WBGene00007201; exos-4.1.
DR   eggNOG; KOG1068; Eukaryota.
DR   GeneTree; ENSGT00940000153348; -.
DR   HOGENOM; CLU_063514_0_0_1; -.
DR   InParanoid; Q17533; -.
DR   OMA; GIAMYDY; -.
DR   OrthoDB; 1394468at2759; -.
DR   PhylomeDB; Q17533; -.
DR   Reactome; R-CEL-429958; mRNA decay by 3' to 5' exoribonuclease.
DR   Reactome; R-CEL-450385; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q17533; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00007201; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0071028; P:nuclear mRNA surveillance; IBA:GO_Central.
DR   GO; GO:0034427; P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; IBA:GO_Central.
DR   GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IBA:GO_Central.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0034475; P:U4 snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.30.230.70; -; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR015847; ExoRNase_PH_dom2.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR018336; RNase_PH_CS.
DR   Pfam; PF01138; RNase_PH; 1.
DR   Pfam; PF03725; RNase_PH_C; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
DR   PROSITE; PS01277; RIBONUCLEASE_PH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Exosome; Nucleus; Reference proteome; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..240
FT                   /note="Putative exosome complex component RRP41"
FT                   /id="PRO_0000139960"
SQ   SEQUENCE   240 AA;  26065 MW;  EF4C60483A6F4E41 CRC64;
     MNIISEHGFR IDGRRPAQIR NINTRLGLNR NAEGSCYLEH GNTKVLCAVY GPYEGKSSKR
     IEDKCAIVCQ YSATKFSGLE RKNRTRGDRK STEISRLLEK AFESVILTEA FPRSQLDIFC
     EVIQGDGSNL AACVNATSLA LADAGIPMKG IASAATCGVV DGKPIVDLTS REETDLLPRV
     TLATICGRDE VILVELQNRL HIDHLSTVMD AAKATCADVY ECLAVVAQQH LKACAPILGN