ID   EXOS6_DANRE             Reviewed;         271 AA.
AC   Q6P0I8; Q503U8;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Exosome complex component MTR3;
DE   AltName: Full=Exosome component 6;
DE   AltName: Full=mRNA transport regulator 3 homolog;
GN   Name=exosc6; Synonyms=mtr3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-catalytic component of the RNA exosome complex which has
CC       3'->5' exoribonuclease activity and participates in a multitude of
CC       cellular RNA processing and degradation events. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA exosome complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. {ECO:0000305}.
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DR   EMBL; BC065602; AAH65602.2; -; mRNA.
DR   EMBL; BC095173; AAH95173.1; -; mRNA.
DR   RefSeq; NP_001018322.1; NM_001020486.1.
DR   AlphaFoldDB; Q6P0I8; -.
DR   SMR; Q6P0I8; -.
DR   STRING; 7955.ENSDARP00000052347; -.
DR   PaxDb; Q6P0I8; -.
DR   Ensembl; ENSDART00000052348; ENSDARP00000052347; ENSDARG00000036060.
DR   Ensembl; ENSDART00000184921; ENSDARP00000156298; ENSDARG00000115735.
DR   GeneID; 326786; -.
DR   KEGG; dre:326786; -.
DR   CTD; 118460; -.
DR   ZFIN; ZDB-GENE-050522-362; exosc6.
DR   eggNOG; KOG1068; Eukaryota.
DR   GeneTree; ENSGT00940000153348; -.
DR   HOGENOM; CLU_063514_1_3_1; -.
DR   InParanoid; Q6P0I8; -.
DR   OMA; RCGLVSQ; -.
DR   OrthoDB; 1101132at2759; -.
DR   PhylomeDB; Q6P0I8; -.
DR   TreeFam; TF323886; -.
DR   Reactome; R-DRE-429958; mRNA decay by 3' to 5' exoribonuclease.
DR   Reactome; R-DRE-450385; Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA.
DR   Reactome; R-DRE-450513; Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA.
DR   Reactome; R-DRE-450604; KSRP (KHSRP) binds and destabilizes mRNA.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q6P0I8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000036060; Expressed in ovary and 22 other tissues.
DR   ExpressionAtlas; Q6P0I8; baseline.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0071028; P:nuclear mRNA surveillance; IBA:GO_Central.
DR   GO; GO:0034427; P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; IBA:GO_Central.
DR   GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IBA:GO_Central.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0034475; P:U4 snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.30.230.70; -; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   Pfam; PF01138; RNase_PH; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Exosome; Nucleus; Reference proteome; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..271
FT                   /note="Exosome complex component MTR3"
FT                   /id="PRO_0000287480"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   271 AA;  29457 MW;  AEC1307B0E7FADBA CRC64;
     MPVDTKRIRG PEESQSPLLF LSPDKAPKAP SSRQGVRGNG DVRPVFARCG LVSQAKGSAY
     IEAGNTKIIC SVYGPKETER RDETDMKTGR LVCDFRLAPF SCVKRGAWIQ GSEERDLSAT
     LMESLRPGVC LHRYPRSQID VNVMVLENDG SVLAHAVTCA SMALADAGIE MYDIVLGCTL
     RQSGNACLVD PSYAEECGSW QEGYGDNQGC VTLALLPNLN QVSGLNADGE MREDTLTEAM
     RTCMDGCHKL YPVVQQALTR AVKKKAPPPE K