ID   EXOS6_XENTR             Reviewed;         270 AA.
AC   Q28F19;
DT   15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Exosome complex component MTR3;
DE   AltName: Full=Exosome component 6;
DE   AltName: Full=mRNA transport regulator 3 homolog;
GN   Name=exosc6; Synonyms=mtr3; ORFNames=TGas126k07.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Non-catalytic component of the RNA exosome complex which has
CC       3'->5' exoribonuclease activity and participates in a multitude of
CC       cellular RNA processing and degradation events. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the RNA exosome complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC       {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNase PH family. {ECO:0000305}.
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DR   EMBL; CR762221; CAJ81566.1; -; mRNA.
DR   EMBL; BC136080; AAI36081.1; -; mRNA.
DR   RefSeq; NP_001017016.1; NM_001017016.2.
DR   AlphaFoldDB; Q28F19; -.
DR   SMR; Q28F19; -.
DR   STRING; 8364.ENSXETP00000016677; -.
DR   PaxDb; Q28F19; -.
DR   DNASU; 549770; -.
DR   Ensembl; ENSXETT00000016677; ENSXETP00000016677; ENSXETG00000007667.
DR   GeneID; 549770; -.
DR   KEGG; xtr:549770; -.
DR   CTD; 118460; -.
DR   Xenbase; XB-GENE-998313; exosc6.
DR   eggNOG; KOG1068; Eukaryota.
DR   HOGENOM; CLU_063514_1_3_1; -.
DR   InParanoid; Q28F19; -.
DR   OMA; NIKEDPY; -.
DR   OrthoDB; 1101132at2759; -.
DR   PhylomeDB; Q28F19; -.
DR   TreeFam; TF323886; -.
DR   Reactome; R-XTR-429958; mRNA decay by 3' to 5' exoribonuclease.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000007667; Expressed in ovary and 12 other tissues.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000178; C:exosome (RNase complex); ISS:UniProtKB.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0071028; P:nuclear mRNA surveillance; IBA:GO_Central.
DR   GO; GO:0034427; P:nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'; IBA:GO_Central.
DR   GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IBA:GO_Central.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0034475; P:U4 snRNA 3'-end processing; IBA:GO_Central.
DR   Gene3D; 3.30.230.70; -; 1.
DR   InterPro; IPR001247; ExoRNase_PH_dom1.
DR   InterPro; IPR036345; ExoRNase_PH_dom2_sf.
DR   InterPro; IPR027408; PNPase/RNase_PH_dom_sf.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   Pfam; PF01138; RNase_PH; 1.
DR   SUPFAM; SSF54211; SSF54211; 1.
DR   SUPFAM; SSF55666; SSF55666; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Exosome; Nucleus; Reference proteome; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..270
FT                   /note="Exosome complex component MTR3"
FT                   /id="PRO_0000287481"
FT   REGION          23..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   270 AA;  28655 MW;  3812792F805E0C83 CRC64;
     MPGDSRRIRG PEESQSPLLY VLSEEGGKAA GRRGRGPSEP RPVFVRAGLL SQAKGSAYLE
     AGSGGTKVLC AVHGPRERGM GGERAETRGR LLCDLRWAPF SRRGPWSGSC PAGPSPRQAG
     LQLQESLEPA VRLDRYPRAE VIVWVLVLED RGSALPAAVS CASLALADAG IEMFDLALGC
     GLSRGPGGEL LLDPDDDEEE AGSGGTMSLS LLPTLNQVSG LISSGEWEGE SSEEAVRLCM
     EGCQRLYPVL HQCLVKATKR KIPVPQPDTN