ID   EXOX_ECOL6              Reviewed;         220 AA.
AC   P0AEK1; P76281;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Exodeoxyribonuclease 10;
DE            EC=3.1.11.-;
DE   AltName: Full=Exodeoxyribonuclease X;
DE            Short=Exo X;
DE            Short=Exonuclease X;
GN   Name=exoX; OrderedLocusNames=c2254;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Capable of degrading both single-strand and double-strand DNA
CC       with 3' to 5' polarity. Has higher affinity for ssDNA ends than for
CC       dsDNA (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN80713.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN80713.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000944256.1; NC_004431.1.
DR   AlphaFoldDB; P0AEK1; -.
DR   SMR; P0AEK1; -.
DR   STRING; 199310.c2254; -.
DR   DNASU; 1036778; -.
DR   EnsemblBacteria; AAN80713; AAN80713; c2254.
DR   GeneID; 66674266; -.
DR   KEGG; ecc:c2254; -.
DR   eggNOG; COG0847; Bacteria.
DR   HOGENOM; CLU_047806_8_2_6; -.
DR   OMA; SPYYVAH; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR013520; Exonuclease_RNaseT/DNA_pol3.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF00929; RNase_T; 1.
DR   SMART; SM00479; EXOIII; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Exonuclease; Hydrolase; Magnesium; Nuclease.
FT   CHAIN           1..220
FT                   /note="Exodeoxyribonuclease 10"
FT                   /id="PRO_0000087137"
SQ   SEQUENCE   220 AA;  25133 MW;  A1863A22C8C57A6F CRC64;
     MLRIIDTETC GLQGGIVEIA SVDVIDGKIV NPMSHLVRPD RPISPQAMAI HRITEAMVAD
     KPWIEDVIPH YYGSEWYVAH NASFDRRVLP EMPGEWICTM KLARRLWPGI KYSNMALYKT
     RKLNVQTPPG LHHHRALYDC YITAALLIDI MNTSGWTAEQ MADITGRPSL MTTFTFGKYR
     GKAVSDVAER DPGYLRWLFN NLDSMSPELR LTLKHYLENT