EXP1_PLAFA
ID EXP1_PLAFA Reviewed; 162 AA.
AC P04926; P06718;
DT 13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 2.
DT 25-MAY-2022, entry version 72.
DE RecName: Full=Malaria protein EXP-1;
DE AltName: Full=Exported antigen AG 5.1;
DE Flags: Precursor;
GN Name=EXP-1;
OS Plasmodium falciparum.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2438130; DOI=10.1002/j.1460-2075.1987.tb04779.x;
RA Simmons D., Woollett G., Bergin-Cartwright M., Kay D., Scaife J.;
RT "A malaria protein exported into a new compartment within the host
RT erythrocyte.";
RL EMBO J. 6:485-491(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2582354; DOI=10.1093/nar/13.2.369;
RA Hope I.A., McKay M., Hyde J.E., Goman M., Scaife J.;
RT "The gene for an exported antigen of the malaria parasite Plasmodium
RT falciparum cloned and expressed in Escherichia coli.";
RL Nucleic Acids Res. 13:369-379(1985).
CC -!- SUBCELLULAR LOCATION: Parasitophorous vacuole membrane {ECO:0000305}.
CC -!- MISCELLANEOUS: This protein is addressed to a new compartment within
CC the cytoplasm of the infected red cell. It also surrounds the parasite,
CC probably in the parasitophorous vacuole membrane.
CC -!- MISCELLANEOUS: This antigen and the circumsporozoite protein appear to
CC have a common epitope.
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DR EMBL; X05074; CAA28735.1; -; Genomic_DNA.
DR EMBL; X01745; CAA25881.1; -; mRNA.
DR PIR; A23052; YAZQ51.
DR PIR; A26769; A26769.
DR AlphaFoldDB; P04926; -.
DR IntAct; P04926; 1.
DR MINT; P04926; -.
DR DrugBank; DB09274; Artesunate.
DR VEuPathDB; PlasmoDB:PF3D7_1121600; -.
DR VEuPathDB; PlasmoDB:Pf7G8-2_000344300; -.
DR VEuPathDB; PlasmoDB:Pf7G8_110025200; -.
DR VEuPathDB; PlasmoDB:PfCD01_110027000; -.
DR VEuPathDB; PlasmoDB:PfDd2_110024600; -.
DR VEuPathDB; PlasmoDB:PfGA01_110025800; -.
DR VEuPathDB; PlasmoDB:PfGB4_110028100; -.
DR VEuPathDB; PlasmoDB:PfGN01_110026100; -.
DR VEuPathDB; PlasmoDB:PfHB3_110024800; -.
DR VEuPathDB; PlasmoDB:PfIT_110025900; -.
DR VEuPathDB; PlasmoDB:PfKE01_110026100; -.
DR VEuPathDB; PlasmoDB:PfKH01_110025700; -.
DR VEuPathDB; PlasmoDB:PfKH02_110026600; -.
DR VEuPathDB; PlasmoDB:PfML01_110026400; -.
DR VEuPathDB; PlasmoDB:PfNF135_110024700; -.
DR VEuPathDB; PlasmoDB:PfNF166_110025000; -.
DR VEuPathDB; PlasmoDB:PfNF54_110025900; -.
DR VEuPathDB; PlasmoDB:PfSD01_110024200; -.
DR VEuPathDB; PlasmoDB:PfSN01_110024700; -.
DR VEuPathDB; PlasmoDB:PfTG01_110026000; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0020005; C:symbiont-containing vacuole membrane; IEA:UniProtKB-SubCell.
PE 2: Evidence at transcript level;
KW Malaria; Membrane; Signal; Sporozoite; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT CHAIN 23..162
FT /note="Malaria protein EXP-1"
FT /id="PRO_0000024537"
FT TRANSMEM 80..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 109..162
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..137
FT /note="Epitope (deduced)"
FT COMPBIAS 120..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 136
FT /note="D -> G (in Ag5.1 negative strains)"
FT VARIANT 160
FT /note="P -> T (in strain: Palo Alto17 and 3D7)"
FT CONFLICT 10
FT /note="V -> A (in Ref. 2; CAA25881)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 162 AA; 17450 MW; AF6B57446E4AA212 CRC64;
MKILSVFFLV LFFIIFNKES LAEKTNKETG SGVSSKKKNK KGSGEPLIDV HDLISDMIKK
EEELVEVNKR KSKYKLATSV LAGLLGVVST VLLGGVGLVL YNTEKGRHPF KIGSSDPADN
ANPDADSESN GEPNADPQVT AQDVTPEQPQ GDDNNLVSGP EH
