ID   EXP21_ARATH             Reviewed;         262 AA.
AC   Q9FL81; Q84WR9;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2006, sequence version 3.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Expansin-A21;
DE            Short=AtEXPA21;
DE   AltName: Full=Alpha-expansin-21;
DE            Short=At-EXP21;
DE            Short=AtEx21;
DE   AltName: Full=Ath-ExpAlpha-1.20;
DE   Flags: Precursor;
GN   Name=EXPA21; Synonyms=EXP21; OrderedLocusNames=At5g39260;
GN   ORFNames=K3K3.17, K3K3_110;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA   Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT   features of the regions of 1,381,565 bp covered by twenty one physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:131-145(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [4]
RP   NOMENCLATURE.
RX   PubMed=15604683; DOI=10.1007/s11103-004-0158-6;
RA   Kende H., Bradford K.J., Brummell D.A., Cho H.-T., Cosgrove D.J.,
RA   Fleming A.J., Gehring C., Lee Y., McQueen-Mason S.J., Rose J.K.C.,
RA   Voesenek L.A.C.;
RT   "Nomenclature for members of the expansin superfamily of genes and
RT   proteins.";
RL   Plant Mol. Biol. 55:311-314(2004).
CC   -!- FUNCTION: Causes loosening and extension of plant cell walls by
CC       disrupting non-covalent bonding between cellulose microfibrils and
CC       matrix glucans. No enzymatic activity has been found (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, cell wall. Membrane; Peripheral
CC       membrane protein.
CC   -!- SIMILARITY: Belongs to the expansin family. Expansin A subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB09381.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=EXPANSIN homepage;
CC       URL="http://homes.bio.psu.edu/expansins/";
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DR   EMBL; AB010694; BAB09381.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002688; AED94413.1; -; Genomic_DNA.
DR   EMBL; BT002841; AAO22660.1; -; mRNA.
DR   RefSeq; NP_198742.2; NM_123288.3.
DR   AlphaFoldDB; Q9FL81; -.
DR   SMR; Q9FL81; -.
DR   STRING; 3702.AT5G39260.1; -.
DR   PaxDb; Q9FL81; -.
DR   PRIDE; Q9FL81; -.
DR   ProteomicsDB; 222418; -.
DR   EnsemblPlants; AT5G39260.1; AT5G39260.1; AT5G39260.
DR   GeneID; 833922; -.
DR   Gramene; AT5G39260.1; AT5G39260.1; AT5G39260.
DR   KEGG; ath:AT5G39260; -.
DR   Araport; AT5G39260; -.
DR   TAIR; locus:2157215; AT5G39260.
DR   eggNOG; ENOG502QQNJ; Eukaryota.
DR   HOGENOM; CLU_027462_0_1_1; -.
DR   InParanoid; Q9FL81; -.
DR   OMA; TAWYDAR; -.
DR   OrthoDB; 1081008at2759; -.
DR   PhylomeDB; Q9FL81; -.
DR   PRO; PR:Q9FL81; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FL81; baseline and differential.
DR   Genevisible; Q9FL81; AT.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR   GO; GO:0009664; P:plant-type cell wall organization; IEA:InterPro.
DR   Gene3D; 2.40.40.10; -; 1.
DR   Gene3D; 2.60.40.760; -; 1.
DR   InterPro; IPR007118; Expan_Lol_pI.
DR   InterPro; IPR002963; Expansin.
DR   InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR   InterPro; IPR007117; Expansin_CBD.
DR   InterPro; IPR036749; Expansin_CBD_sf.
DR   InterPro; IPR009009; RlpA-like_DPBB.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   PANTHER; PTHR31867; PTHR31867; 1.
DR   Pfam; PF03330; DPBB_1; 1.
DR   Pfam; PF01357; Expansin_C; 1.
DR   PRINTS; PR01226; EXPANSIN.
DR   PRINTS; PR01225; EXPANSNFAMLY.
DR   SMART; SM00837; DPBB_1; 1.
DR   SUPFAM; SSF49590; SSF49590; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
DR   PROSITE; PS50843; EXPANSIN_CBD; 1.
DR   PROSITE; PS50842; EXPANSIN_EG45; 1.
PE   2: Evidence at transcript level;
KW   Cell wall; Cell wall biogenesis/degradation; Membrane; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..262
FT                   /note="Expansin-A21"
FT                   /id="PRO_0000008701"
FT   DOMAIN          64..169
FT                   /note="Expansin-like EG45"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT   DOMAIN          179..258
FT                   /note="Expansin-like CBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00078"
SQ   SEQUENCE   262 AA;  28134 MW;  32D88382879D91B1 CRC64;
     MKLLEKMTYV ECFMIIMATW FMFISYSHGA NVAAAPGTNG LDTAWYDARA AYYGDIHGGG
     TELEGACGYG DLNKHGYGLA TAALSTALFN SGASCGACYE IMCSPNPQGC LSGSIKITAT
     DLCPPGSAWC YLPNKHFDLS LPMFIKIAQV KAKMVPVRYR RVPCAKTGGV KFEVKGNPNI
     LTILPYNVGG AGDIIAVSAK GSKTAWVVMS RYWGQNWTTN VNLTGQSVSL RVTTSDGITK
     DFTDVMPASW GFGQTFDGKT NF