EXP7_STRPN
ID EXP7_STRPN Reviewed; 778 AA.
AC P35597;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2001, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Probable cation-transporting ATPase exp7;
DE EC=7.2.2.-;
DE AltName: Full=Exported protein 7;
GN Name=exp7; OrderedLocusNames=SP_1623;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 402-482.
RC STRAIN=R6x;
RX PubMed=7934910; DOI=10.1111/j.1365-2958.1993.tb01233.x;
RA Pearce B.J., Yin Y.B., Masure H.R.;
RT "Genetic identification of exported proteins in Streptococcus pneumoniae.";
RL Mol. Microbiol. 9:1037-1050(1993).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. {ECO:0000305}.
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DR EMBL; AE005672; AAK75703.1; -; Genomic_DNA.
DR EMBL; L20561; AAA26883.1; -; Genomic_DNA.
DR PIR; F95188; F95188.
DR RefSeq; WP_000360054.1; NZ_AKVY01000001.1.
DR AlphaFoldDB; P35597; -.
DR SMR; P35597; -.
DR STRING; 170187.SP_1623; -.
DR DNASU; 931480; -.
DR EnsemblBacteria; AAK75703; AAK75703; SP_1623.
DR KEGG; spn:SP_1623; -.
DR eggNOG; COG0474; Bacteria.
DR OMA; FFIKTIY; -.
DR PhylomeDB; P35597; -.
DR BioCyc; SPNE170187:G1FZB-1642-MON; -.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 3.40.1110.10; -; 1.
DR Gene3D; 3.40.50.1000; -; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR SUPFAM; SSF81653; SSF81653; 1.
DR SUPFAM; SSF81660; SSF81660; 1.
DR SUPFAM; SSF81665; SSF81665; 1.
DR TIGRFAMs; TIGR01494; ATPase_P-type; 2.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Magnesium; Membrane; Metal-binding;
KW Nucleotide-binding; Phosphoprotein; Translocase; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..778
FT /note="Probable cation-transporting ATPase exp7"
FT /id="PRO_0000046186"
FT TOPO_DOM 1..37
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..57
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 58..64
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 85..209
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 230..242
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 243..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..586
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 587..606
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 607..624
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 625..645
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 646..663
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 664..684
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 685..689
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 690..708
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 709..716
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 717..739
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 740..757
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 758..777
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 778
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT ACT_SITE 298
FT /note="4-aspartylphosphate intermediate"
FT /evidence="ECO:0000250"
FT BINDING 532
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT BINDING 536
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000250"
FT CONFLICT 402..411
FT /note="ERGSRVLVLA -> TASEFELGTP (in Ref. 2; AAA26883)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 778 AA; 85531 MW; 1154C1FAF9DF7818 CRC64;
MDKNKIMGLT QREVKERQAE GLVNDFTASA STSTWQIVKR NVFTLFNALN FAIALALAFV
QAWSNLVFFA VICFNAFSGI VTELRAKHMV DKLNLMTKEK VKTIRDGQEV ALNPEELVLG
DVIRLSAGEQ IPSDALVLEG FAEVNEAMLT GESDLVQKEV DGLLLSGSFL ASGSVLSQVH
HVGADNYAAK LMLEAKTVKP INSRIMKSLD KLAGFTGKII IPFGLALLLE ALLLKGLPLK
SSVVNSSTAL LGMLPKGIAL LTITSLLTAV IKLGLKKVLV QEMYSVETLA RVDMLCLDKT
GTITQGKMQV EAVLPLTETY GEEAIASILT SYMAHSEDKN PTAQAIRQRF VGDVAYPMIS
NLPFSSDRKW GAMELEGLGT VFLGAPEMLL DSEVPEAREA LERGSRVLVL ALSQEKLDHH
KPQKPSDIQA LALLEILDPI REGAAETLDY LRSQEVGLKI ISGDNPVTVS SIAQKAGFAD
YHSYVDCSKI TDEELMAMAE ETAIFGRVSP HQKKLIIQTL KKAGHTTAMT GDGVNDILAL
READCSIVMA EGDPATRQIA NLVLLNSDFN DVPEILFEGR RVVNNIAHIA PIFLIKTIYS
FLLAVICIAS ALLGRSEWIL IFPFIPIQIT MIDQFVEGFP PFVLTFERNI KPVEQNFLRK
SMLRALPSAL MVVFSVLFVK MFGASQGWSE LEISTLLYYL LGSIGFLSVF RACMPFTLWR
VLLIVWSVGG FLATALFPRI QKLLEISTLT EQTLPVYGVM MLVFTVIFIL TSRYQAKK
