EXP8_STRPN
ID EXP8_STRPN Reviewed; 583 AA.
AC P35598;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2001, sequence version 3.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Putative ABC transporter ATP-binding protein exp8;
DE AltName: Full=Exported protein 8;
GN Name=exp8; OrderedLocusNames=SP_1839;
OS Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=170187;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-334 / TIGR4;
RX PubMed=11463916; DOI=10.1126/science.1061217;
RA Tettelin H., Nelson K.E., Paulsen I.T., Eisen J.A., Read T.D.,
RA Peterson S.N., Heidelberg J.F., DeBoy R.T., Haft D.H., Dodson R.J.,
RA Durkin A.S., Gwinn M.L., Kolonay J.F., Nelson W.C., Peterson J.D.,
RA Umayam L.A., White O., Salzberg S.L., Lewis M.R., Radune D.,
RA Holtzapple E.K., Khouri H.M., Wolf A.M., Utterback T.R., Hansen C.L.,
RA McDonald L.A., Feldblyum T.V., Angiuoli S.V., Dickinson T., Hickey E.K.,
RA Holt I.E., Loftus B.J., Yang F., Smith H.O., Venter J.C., Dougherty B.A.,
RA Morrison D.A., Hollingshead S.K., Fraser C.M.;
RT "Complete genome sequence of a virulent isolate of Streptococcus
RT pneumoniae.";
RL Science 293:498-506(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 413-482.
RC STRAIN=R6x;
RX PubMed=7934910; DOI=10.1111/j.1365-2958.1993.tb01233.x;
RA Pearce B.J., Yin Y.B., Masure H.R.;
RT "Genetic identification of exported proteins in Streptococcus pneumoniae.";
RL Mol. Microbiol. 9:1037-1050(1993).
RN [3]
RP IDENTIFICATION OF PROBABLE VECTOR CONTAMINATION.
RA Robison K.;
RL Unpublished observations (NOV-1994).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA26884.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Vector contamination at the N-terminus, a segment of 26 residues, which seems to originate from a pUC-type vector.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE005672; AAK75912.1; -; Genomic_DNA.
DR EMBL; L20562; AAA26884.1; ALT_TERM; Genomic_DNA.
DR PIR; G95214; G95214.
DR RefSeq; WP_001180176.1; NZ_AKVY01000001.1.
DR AlphaFoldDB; P35598; -.
DR SMR; P35598; -.
DR STRING; 170187.SP_1839; -.
DR EnsemblBacteria; AAK75912; AAK75912; SP_1839.
DR KEGG; spn:SP_1839; -.
DR eggNOG; COG1132; Bacteria.
DR OMA; FNTLQMG; -.
DR PhylomeDB; P35598; -.
DR BioCyc; SPNE170187:G1FZB-1868-MON; -.
DR Proteomes; UP000000585; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF90123; SSF90123; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Membrane; Nucleotide-binding; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..583
FT /note="Putative ABC transporter ATP-binding protein exp8"
FT /id="PRO_0000092322"
FT TRANSMEM 26..46
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 61..81
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 135..155
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 159..179
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 25..308
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 341..574
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 374..381
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 441
FT /note="T -> I (in Ref. 2; AAA26884)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 583 AA; 65552 MW; 59D5FBC886D0CBA0 CRC64;
MQNKQEQWTV LKRLMSYLKP YGLLTFLALS FLLATTVIKS VIPLVASHFI DQYLSNLNQL
AVTVLLVYYG LYILQTVVQY VGNLLFARVS YSIVRDIRRD AFANMEKLGM SYFDKTPAGS
IVSRLTNDTE TISDMFSGIL SSFISAVFIF LTTLYTMLVL DFRLTALVLL FLPLIFLLVN
LYRKKSVKII EKTRSLLSDI NSKLAENIEG IRIIQAFNQE KRLQAEFDEI NQEHLVYANR
SVALDALFLR PAMSLLKLLG YAVLMAYFGY RGFSIGITVG TMYAFIQYIN RLFDPLIEVT
QNFSTLQTAM VSAGRVFALI DERTYEPLQE NGQAKVQEGN IRFEHVCFSY DGKHPILDDI
SFSVNKGETI AFVGHTGSGK SSIINVLMRF YEFQSGRVLL DDVDIRDFSQ EELRKNIGLV
LQEPFLYHGT IKSNIAMYQE TSDEQVQAAA AFVDADSFIQ ELPQGYDSPV SERGSSFSTG
QRQLLAFART VASQPKILIL DEATANIDSE TESLVQASLA KMRQGRTTIA IAHRLSTIQD
ANCIYVLDKG RIIESGTHEE LLALGGTYHK MYSLQAGAMA DTL
