EXPA6_ARATH
ID EXPA6_ARATH Reviewed; 257 AA.
AC Q38865; O81065; Q8LDV8;
DT 05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2004, sequence version 2.
DT 25-MAY-2022, entry version 146.
DE RecName: Full=Expansin-A6;
DE Short=AtEXPA6;
DE AltName: Full=Alpha-expansin-6;
DE Short=At-EXP6;
DE Short=AtEx6;
DE AltName: Full=Ath-ExpAlpha-1.8;
DE Flags: Precursor;
GN Name=EXPA6; Synonyms=EXP6; OrderedLocusNames=At2g28950; ORFNames=T9I4.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=7568110; DOI=10.1073/pnas.92.20.9245;
RA Shcherban T.Y., Shi J., Durachko D.M., Guiltinan M.J., McQueen-Mason S.J.,
RA Shieh M., Cosgrove D.J.;
RT "Molecular cloning and sequence analysis of expansins - a highly conserved,
RT multigene family of proteins that mediate cell wall extension in plants.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:9245-9249(1995).
RN [2]
RP SEQUENCE REVISION TO 10-11.
RA Cosgrove D.J.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [6]
RP NOMENCLATURE.
RX PubMed=15604683; DOI=10.1007/s11103-004-0158-6;
RA Kende H., Bradford K.J., Brummell D.A., Cho H.-T., Cosgrove D.J.,
RA Fleming A.J., Gehring C., Lee Y., McQueen-Mason S.J., Rose J.K.C.,
RA Voesenek L.A.C.;
RT "Nomenclature for members of the expansin superfamily of genes and
RT proteins.";
RL Plant Mol. Biol. 55:311-314(2004).
CC -!- FUNCTION: Causes loosening and extension of plant cell walls by
CC disrupting non-covalent bonding between cellulose microfibrils and
CC matrix glucans. No enzymatic activity has been found (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall. Membrane; Peripheral
CC membrane protein.
CC -!- SIMILARITY: Belongs to the expansin family. Expansin A subfamily.
CC {ECO:0000305}.
CC -!- WEB RESOURCE: Name=EXPANSIN homepage;
CC URL="http://homes.bio.psu.edu/expansins/";
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DR EMBL; U30480; AAB38072.2; -; mRNA.
DR EMBL; AC005315; AAC33223.1; -; Genomic_DNA.
DR EMBL; AC005727; AAM15074.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08194.1; -; Genomic_DNA.
DR EMBL; AY058193; AAL25606.1; -; mRNA.
DR EMBL; AY072409; AAL62401.1; -; mRNA.
DR EMBL; AY085770; AAM62987.1; -; mRNA.
DR EMBL; BT003405; AAO30068.1; -; mRNA.
DR PIR; T02727; T02727.
DR PIR; T50653; T50653.
DR RefSeq; NP_180461.1; NM_128454.3.
DR AlphaFoldDB; Q38865; -.
DR SMR; Q38865; -.
DR STRING; 3702.AT2G28950.1; -.
DR PaxDb; Q38865; -.
DR PRIDE; Q38865; -.
DR ProteomicsDB; 222241; -.
DR EnsemblPlants; AT2G28950.1; AT2G28950.1; AT2G28950.
DR GeneID; 817444; -.
DR Gramene; AT2G28950.1; AT2G28950.1; AT2G28950.
DR KEGG; ath:AT2G28950; -.
DR Araport; AT2G28950; -.
DR TAIR; locus:2053260; AT2G28950.
DR eggNOG; ENOG502QR06; Eukaryota.
DR HOGENOM; CLU_027462_0_1_1; -.
DR InParanoid; Q38865; -.
DR OMA; GTHTSWM; -.
DR OrthoDB; 979254at2759; -.
DR PhylomeDB; Q38865; -.
DR PRO; PR:Q38865; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q38865; baseline and differential.
DR Genevisible; Q38865; AT.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009505; C:plant-type cell wall; HDA:TAIR.
DR GO; GO:0009664; P:plant-type cell wall organization; IEA:InterPro.
DR GO; GO:0006949; P:syncytium formation; IEP:TAIR.
DR Gene3D; 2.40.40.10; -; 1.
DR Gene3D; 2.60.40.760; -; 1.
DR InterPro; IPR007118; Expan_Lol_pI.
DR InterPro; IPR002963; Expansin.
DR InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR InterPro; IPR007117; Expansin_CBD.
DR InterPro; IPR036749; Expansin_CBD_sf.
DR InterPro; IPR009009; RlpA-like_DPBB.
DR InterPro; IPR036908; RlpA-like_sf.
DR PANTHER; PTHR31867; PTHR31867; 1.
DR Pfam; PF03330; DPBB_1; 1.
DR Pfam; PF01357; Expansin_C; 1.
DR PRINTS; PR01226; EXPANSIN.
DR PRINTS; PR01225; EXPANSNFAMLY.
DR SMART; SM00837; DPBB_1; 1.
DR SUPFAM; SSF49590; SSF49590; 1.
DR SUPFAM; SSF50685; SSF50685; 1.
DR PROSITE; PS50843; EXPANSIN_CBD; 1.
DR PROSITE; PS50842; EXPANSIN_EG45; 1.
PE 2: Evidence at transcript level;
KW Cell wall; Cell wall biogenesis/degradation; Disulfide bond; Membrane;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..257
FT /note="Expansin-A6"
FT /id="PRO_0000008687"
FT DOMAIN 49..163
FT /note="Expansin-like EG45"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT DOMAIN 173..252
FT /note="Expansin-like CBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00078"
FT DISULFID 52..80
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT DISULFID 83..158
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT DISULFID 88..95
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
SQ SEQUENCE 257 AA; 27818 MW; F24152B9BF05A510 CRC64;
MAMLGLVLSV LTTILALSEA RIPGVYNGGG WETAHATFYG GSDASGTMGG ACGYGNLYSQ
GYGVNTAALS TALFNNGFSC GACFELKCAS DPKWCHSGSP SIFITATNFC PPNFAQPSDN
GGWCNPPRPH FDLAMPMFLK IAEYRAGIVP VSFRRVPCRK RGGIRFTING FRYFNLVLVT
NVAGAGNIVR LGVKGTHTSW MTMSRNWGQN WQSNSVLVGQ SLSFRVTSSD RRSSTSWNIA
PANWKFGQTF MGKNFRV
