ID   EXPI_DICD3              Reviewed;         212 AA.
AC   Q47187; E0SME6;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Acyl-homoserine-lactone synthase;
DE            EC=2.3.1.184;
DE   AltName: Full=Autoinducer synthesis protein ExpI;
GN   Name=expI; OrderedLocusNames=Dda3937_03219;
OS   Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=198628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=3937;
RX   PubMed=9781877; DOI=10.1046/j.1365-2958.1998.01022.x;
RA   Nasser W., Bouillant M.L., Salmond G., Reverchon S.;
RT   "Characterization of the Erwinia chrysanthemi expI-expR locus directing the
RT   synthesis of two N-acyl-homoserine lactone signal molecules.";
RL   Mol. Microbiol. 29:1391-1405(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3937;
RX   PubMed=21217001; DOI=10.1128/jb.01513-10;
RA   Glasner J.D., Yang C.H., Reverchon S., Hugouvieux-Cotte-Pattat N.,
RA   Condemine G., Bohin J.P., Van Gijsegem F., Yang S., Franza T., Expert D.,
RA   Plunkett G. III, San Francisco M.J., Charkowski A.O., Py B., Bell K.,
RA   Rauscher L., Rodriguez-Palenzuela P., Toussaint A., Holeva M.C., He S.Y.,
RA   Douet V., Boccara M., Blanco C., Toth I., Anderson B.D., Biehl B.S.,
RA   Mau B., Flynn S.M., Barras F., Lindeberg M., Birch P.R., Tsuyumu S.,
RA   Shi X., Hibbing M., Yap M.N., Carpentier M., Dassa E., Umehara M.,
RA   Kim J.F., Rusch M., Soni P., Mayhew G.F., Fouts D.E., Gill S.R.,
RA   Blattner F.R., Keen N.T., Perna N.T.;
RT   "Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.";
RL   J. Bacteriol. 193:2076-2077(2011).
CC   -!- FUNCTION: Required for the synthesis of OHHL (N-(3-oxohexanoyl)-L-
CC       homoserine lactone), an autoinducer molecule which binds to ExpR and
CC       thus acts in virulence (soft rot disease) through the activation of
CC       genes for plant tissue macerating enzymes.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a fatty acyl-[ACP] + S-adenosyl-L-methionine = an N-acyl-L-
CC         homoserine lactone + H(+) + holo-[ACP] + S-methyl-5'-thioadenosine;
CC         Xref=Rhea:RHEA:10096, Rhea:RHEA-COMP:9685, Rhea:RHEA-COMP:14125,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17509, ChEBI:CHEBI:55474,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64479, ChEBI:CHEBI:138651;
CC         EC=2.3.1.184;
CC   -!- SIMILARITY: Belongs to the autoinducer synthase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00533}.
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DR   EMBL; X96440; CAA65306.1; -; Genomic_DNA.
DR   EMBL; CP002038; ADN00585.1; -; Genomic_DNA.
DR   RefSeq; WP_013319980.1; NC_014500.1.
DR   AlphaFoldDB; Q47187; -.
DR   SMR; Q47187; -.
DR   STRING; 198628.Dda3937_03219; -.
DR   PRIDE; Q47187; -.
DR   EnsemblBacteria; ADN00585; ADN00585; Dda3937_03219.
DR   GeneID; 9735886; -.
DR   KEGG; ddd:Dda3937_03219; -.
DR   PATRIC; fig|198628.6.peg.4338; -.
DR   eggNOG; COG3916; Bacteria.
DR   HOGENOM; CLU_085711_4_1_6; -.
DR   OMA; NCINGME; -.
DR   OrthoDB; 1725271at2; -.
DR   BioCyc; DDAD198628:DDA3937_RS20725-MON; -.
DR   Proteomes; UP000006859; Chromosome.
DR   GO; GO:0061579; F:N-acyl homoserine lactone synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR018311; Autoind_synth_CS.
DR   InterPro; IPR001690; Autoind_synthase.
DR   PANTHER; PTHR39322; PTHR39322; 1.
DR   Pfam; PF00765; Autoind_synth; 1.
DR   PRINTS; PR01549; AUTOINDCRSYN.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS00949; AUTOINDUCER_SYNTH_1; 1.
DR   PROSITE; PS51187; AUTOINDUCER_SYNTH_2; 1.
PE   3: Inferred from homology;
KW   Autoinducer synthesis; Quorum sensing; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase; Virulence.
FT   CHAIN           1..212
FT                   /note="Acyl-homoserine-lactone synthase"
FT                   /id="PRO_0000210886"
SQ   SEQUENCE   212 AA;  24670 MW;  F3FA5D7457F7964A CRC64;
     MLEIFDVSFS LMSNNKLDEV FALRKGTFKD RLDWTVNCIN GMEFDEYDNE HTTYLLGVKE
     GKIICSVRFI EMKYPNMITG TFFSYFDGLN IPEGNYIESS RFFVDRDRVR NLIGTRNPAC
     LTLFLAMINY ARKYHYDGIL TIVSHPMLTL LKRSGWRISI IQQGLSEKQE KIYLLHLPTD
     DESRYALIER ITRITNAESE QLTTLPLLVP LA