EXPL1_DICDI
ID EXPL1_DICDI Reviewed; 286 AA.
AC Q55G31;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Expansin-like protein 1;
DE Short=Ddexpl1;
DE Flags: Precursor;
GN Name=expl1; ORFNames=DDB_G0267846;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP DEVELOPMENTAL STAGE, AND FUNCTION.
RX PubMed=12832080; DOI=10.1016/s0014-5793(03)00598-2;
RA Darley C.P., Li Y., Schaap P., McQueen-Mason S.J.;
RT "Expression of a family of expansin-like proteins during the development of
RT Dictyostelium discoideum.";
RL FEBS Lett. 546:416-418(2003).
RN [3]
RP FUNCTION.
RX PubMed=11891242; DOI=10.1104/pp.010658;
RA Li Y., Darley C.P., Ongaro V., Fleming A., Schipper O., Baldauf S.L.,
RA McQueen-Mason S.J.;
RT "Plant expansins are a complex multigene family with an ancient
RT evolutionary origin.";
RL Plant Physiol. 128:854-864(2002).
RN [4]
RP IDENTIFICATION.
RX PubMed=18559084; DOI=10.1186/1471-2164-9-291;
RA Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B.,
RA Skelton J., Ivens A., Bozzaro S.;
RT "Genome-wide transcriptional changes induced by phagocytosis or growth on
RT bacteria in Dictyostelium.";
RL BMC Genomics 9:291-291(2008).
CC -!- FUNCTION: May serve to lubricate the movement of the cellulose
CC microfibrils during cell growth and wall extension and/or they may
CC serve to maintain the fluid state of the slug cell wall.
CC {ECO:0000269|PubMed:11891242, ECO:0000269|PubMed:12832080}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed at substantial levels throughout
CC development with some slight variations. {ECO:0000269|PubMed:12832080}.
CC -!- SIMILARITY: Belongs to the expansin family. Expansin A subfamily.
CC {ECO:0000305}.
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DR EMBL; AAFI02000003; EAL73376.1; -; Genomic_DNA.
DR RefSeq; XP_647352.1; XM_642260.1.
DR AlphaFoldDB; Q55G31; -.
DR SMR; Q55G31; -.
DR PaxDb; Q55G31; -.
DR EnsemblProtists; EAL73376; EAL73376; DDB_G0267846.
DR GeneID; 8616163; -.
DR KEGG; ddi:DDB_G0267846; -.
DR dictyBase; DDB_G0267846; expl1.
DR eggNOG; ENOG502S9SU; Eukaryota.
DR HOGENOM; CLU_071727_0_0_1; -.
DR InParanoid; Q55G31; -.
DR OMA; ASEWLEM; -.
DR PhylomeDB; Q55G31; -.
DR PRO; PR:Q55G31; -.
DR Proteomes; UP000002195; Chromosome 1.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR Gene3D; 2.40.40.10; -; 1.
DR Gene3D; 2.60.40.760; -; 1.
DR InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR InterPro; IPR036749; Expansin_CBD_sf.
DR InterPro; IPR009009; RlpA-like_DPBB.
DR InterPro; IPR036908; RlpA-like_sf.
DR Pfam; PF03330; DPBB_1; 1.
DR SMART; SM00837; DPBB_1; 1.
DR SUPFAM; SSF49590; SSF49590; 1.
DR SUPFAM; SSF50685; SSF50685; 1.
DR PROSITE; PS50842; EXPANSIN_EG45; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..286
FT /note="Expansin-like protein 1"
FT /id="PRO_0000368215"
FT TOPO_DOM 22..265
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 44..145
FT /note="Expansin-like EG45"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT CARBOHYD 82
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 89
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 47..77
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT DISULFID 80..140
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
SQ SEQUENCE 286 AA; 30606 MW; 7C67E8DF409BE3E4 CRC64;
MKTFVLFVIL LCLTFLSISK SETCPFSQSL VSGASATYYT DPNAGNCGYE NLMGPLGPGN
LFIAALGPNL YNNGKNCGQC FNISSPYTNR SVVIMATDSC PDSGYCQRSS HFDLSTQAFD
VLGAQSIGVL EGLTYYKVPC GVNGNVKIMM KDGSNDYWTA FLIYNSKVTI KDVSVKITGK
STYTSLTQSS YNYWISPNMV PGSFDVRIES VGGEFIYITI PKVESRKQYE TSSQFSVDGC
VGTPSGPSGG LGSPSTGASI GTPSDASSLT LYALFSLTIL FLVMLN
