ID   EXPL2_DICDI             Reviewed;         407 AA.
AC   Q54PA4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Expansin-like protein 2;
DE            Short=Ddexpl2;
DE   Flags: Precursor;
GN   Name=expl2; ORFNames=DDB_G0284677;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   SUBCELLULAR LOCATION, AND FUNCTION.
RX   PubMed=12832080; DOI=10.1016/s0014-5793(03)00598-2;
RA   Darley C.P., Li Y., Schaap P., McQueen-Mason S.J.;
RT   "Expression of a family of expansin-like proteins during the development of
RT   Dictyostelium discoideum.";
RL   FEBS Lett. 546:416-418(2003).
RN   [3]
RP   FUNCTION.
RX   PubMed=11891242; DOI=10.1104/pp.010658;
RA   Li Y., Darley C.P., Ongaro V., Fleming A., Schipper O., Baldauf S.L.,
RA   McQueen-Mason S.J.;
RT   "Plant expansins are a complex multigene family with an ancient
RT   evolutionary origin.";
RL   Plant Physiol. 128:854-864(2002).
CC   -!- FUNCTION: Unlikely to encode with a protein with expansin activity.
CC       {ECO:0000269|PubMed:11891242, ECO:0000269|PubMed:12832080}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12832080}.
CC   -!- SIMILARITY: Belongs to the expansin family. Expansin A subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000070; EAL65108.1; -; Genomic_DNA.
DR   RefSeq; XP_638471.1; XM_633379.1.
DR   AlphaFoldDB; Q54PA4; -.
DR   SMR; Q54PA4; -.
DR   STRING; 44689.DDB0231624; -.
DR   PaxDb; Q54PA4; -.
DR   EnsemblProtists; EAL65108; EAL65108; DDB_G0284677.
DR   GeneID; 8624722; -.
DR   KEGG; ddi:DDB_G0284677; -.
DR   dictyBase; DDB_G0284677; expl2.
DR   eggNOG; ENOG502SBE5; Eukaryota.
DR   HOGENOM; CLU_620314_0_0_1; -.
DR   InParanoid; Q54PA4; -.
DR   OMA; RSTWYEA; -.
DR   PhylomeDB; Q54PA4; -.
DR   PRO; PR:Q54PA4; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   Gene3D; 2.40.40.10; -; 1.
DR   Gene3D; 2.60.40.760; -; 1.
DR   InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR   InterPro; IPR036749; Expansin_CBD_sf.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
DR   PROSITE; PS50842; EXPANSIN_EG45; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..407
FT                   /note="Expansin-like protein 2"
FT                   /id="PRO_0000368216"
FT   DOMAIN          42..141
FT                   /note="Expansin-like EG45"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT   CARBOHYD        70
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        117
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        387
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        45..75
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT   DISULFID        78..136
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
SQ   SEQUENCE   407 AA;  43807 MW;  1995B5CFE4C2CEED CRC64;
     MKMKNFLSKS LLVLLIGLIG VKSADLSDCF SSRSTWYEAI QHGNCGYEQL TGKLGPGNLM
     IAAAATALYN GSFACGECYE IYGPGGTGKV MIVDQCPDPG WCDTPFPHLD LSPTAFNTTI
     GSTVGVAMTT VKKVSCDVTG NIKAYMKDAA TTNTWFEFMV FNHRVGIASI SVEDSKGTIT
     SLPRRLYNYW TYNGNAASFP VIAHVYSIYG DQVDIYLTSS AGAQLYEGVG QFADPATTFA
     DDCTAPFPVD TDGYIYDNGL VKPLNYNHPN LGWSDWSNGV TVNWADSSTP GADSTSKVVA
     SGTLAYNTGI QIGTDLPVEW EGRFTALEFY IKADKDFTGL VVEYNGASKS QTPSLTTTWT
     KYTYDLTKDL GAPASLGKPA ALKFRNNGSG SVKVYLDKIR LTPVASS