ID   EXPL6_DICDI             Reviewed;         292 AA.
AC   Q55G32;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Expansin-like protein 6;
DE            Short=Ddexpl6;
DE   Flags: Precursor;
GN   Name=expl6; ORFNames=DDB_G0267844;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   DEVELOPMENTAL STAGE, AND FUNCTION.
RX   PubMed=12832080; DOI=10.1016/s0014-5793(03)00598-2;
RA   Darley C.P., Li Y., Schaap P., McQueen-Mason S.J.;
RT   "Expression of a family of expansin-like proteins during the development of
RT   Dictyostelium discoideum.";
RL   FEBS Lett. 546:416-418(2003).
RN   [3]
RP   FUNCTION.
RX   PubMed=11891242; DOI=10.1104/pp.010658;
RA   Li Y., Darley C.P., Ongaro V., Fleming A., Schipper O., Baldauf S.L.,
RA   McQueen-Mason S.J.;
RT   "Plant expansins are a complex multigene family with an ancient
RT   evolutionary origin.";
RL   Plant Physiol. 128:854-864(2002).
CC   -!- FUNCTION: May serve to lubricate the movement of the cellulose
CC       microfibrils during cell growth and wall extension and/or may serve to
CC       maintain the fluid state of the slug cell wall.
CC       {ECO:0000269|PubMed:11891242, ECO:0000269|PubMed:12832080}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: No detectable expression.
CC       {ECO:0000269|PubMed:12832080}.
CC   -!- SIMILARITY: Belongs to the expansin family. Expansin A subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000003; EAL73375.1; -; Genomic_DNA.
DR   RefSeq; XP_647351.1; XM_642259.1.
DR   AlphaFoldDB; Q55G32; -.
DR   SMR; Q55G32; -.
DR   PaxDb; Q55G32; -.
DR   EnsemblProtists; EAL73375; EAL73375; DDB_G0267844.
DR   GeneID; 8616162; -.
DR   KEGG; ddi:DDB_G0267844; -.
DR   dictyBase; DDB_G0267844; expl6.
DR   HOGENOM; CLU_071727_0_0_1; -.
DR   InParanoid; Q55G32; -.
DR   OMA; VHCSGWI; -.
DR   PhylomeDB; Q55G32; -.
DR   PRO; PR:Q55G32; -.
DR   Proteomes; UP000002195; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   Gene3D; 2.40.40.10; -; 1.
DR   Gene3D; 2.60.40.760; -; 1.
DR   InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR   InterPro; IPR036749; Expansin_CBD_sf.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   SUPFAM; SSF49590; SSF49590; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
DR   PROSITE; PS50842; EXPANSIN_EG45; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..292
FT                   /note="Expansin-like protein 6"
FT                   /id="PRO_0000368219"
FT   TOPO_DOM        25..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        289..292
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          47..150
FT                   /note="Expansin-like EG45"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT   CARBOHYD        92
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        50..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT   DISULFID        83..145
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
SQ   SEQUENCE   292 AA;  32576 MW;  C899569E01F5D799 CRC64;
     MIKIIYLIVL LVLLFKNNHI IIKADDCPFP QIPIKTLSGT WYDDPDHASC GFEKLTGPLG
     PGNRLVVALG SKLFDKGANC GQCYDVTSPF NNKTITVMAT DSCHDAGYCQ ADNHFDFYKE
     AFDLLGSPSG VISGNSGLSY IKVPCPTYGN VKIMMKDGSN EFWTSFLIFN SRILIKQVSI
     KLSNSQQFID LNRQPQGNYW PSTNMVSGEF EVRIESIGGE FIYVKIPSIE SRKIYDTGNQ
     FSADGCVGNK YDPYAPFQIT SNSNNILPPS LYIIFLISIL FLIINNIFSN KY