EXPL7_DICDI
ID EXPL7_DICDI Reviewed; 553 AA.
AC Q54J35;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Expansin-like protein 7;
DE Short=Ddexpl7;
DE Flags: Precursor;
GN Name=expl7; ORFNames=DDB_G0288331;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=12796308; DOI=10.1128/ec.2.3.627-637.2003;
RA Maeda M., Sakamoto H., Iranfar N., Fuller D., Maruo T., Ogihara S.,
RA Morio T., Urushihara H., Tanaka Y., Loomis W.F.;
RT "Changing patterns of gene expression in Dictyostelium prestalk cell
RT subtypes recognized by in situ hybridization with genes from microarray
RT analyses.";
RL Eukaryot. Cell 2:627-637(2003).
RN [3]
RP IDENTIFICATION.
RX PubMed=15470253; DOI=10.1128/ec.3.5.1241-1248.2004;
RA Maruo T., Sakamoto H., Iranfar N., Fuller D., Morio T., Urushihara H.,
RA Tanaka Y., Maeda M., Loomis W.F.;
RT "Control of cell type proportioning in Dictyostelium discoideum by
RT differentiation-inducing factor as determined by in situ hybridization.";
RL Eukaryot. Cell 3:1241-1248(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=15470642; DOI=10.1387/ijdb.041862ns;
RA Shimada N., Maeda M., Urushihara H., Kawata T.;
RT "Identification of new modes of Dd-STATa regulation of gene expression in
RT Dictyostelium by in situ hybridisation.";
RL Int. J. Dev. Biol. 48:679-682(2004).
RN [5]
RP IDENTIFICATION, DISRUPTION PHENOTYPE, AND DEVELOPMENTAL STAGE.
RX PubMed=19207182; DOI=10.1111/j.1440-169x.2009.01086.x;
RA Ogasawara S., Shimada N., Kawata T.;
RT "Role of an expansin-like molecule in Dictyostelium morphogenesis and
RT regulation of its gene expression by the signal transducer and activator of
RT transcription protein Dd-STATa.";
RL Dev. Growth Differ. 51:109-122(2009).
CC -!- FUNCTION: May serve to lubricate the movement of the cellulose
CC microfibrils during cell growth and wall extension and/or may serve to
CC maintain the fluid state of the slug cell wall (By similarity).
CC Overexpression shows aberrant stalk formation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: First detectable at the migrating slug stage.
CC Observed throughout slug migration and culmination, and remains present
CC in tip organizer cells. {ECO:0000269|PubMed:19207182}.
CC -!- DISRUPTION PHENOTYPE: No phenotypic change.
CC {ECO:0000269|PubMed:19207182}.
CC -!- SIMILARITY: Belongs to the expansin family. Expansin A subfamily.
CC {ECO:0000305}.
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DR EMBL; AAFI02000111; EAL63262.1; -; Genomic_DNA.
DR RefSeq; XP_636766.1; XM_631674.1.
DR AlphaFoldDB; Q54J35; -.
DR SMR; Q54J35; -.
DR STRING; 44689.DDB0229900; -.
DR PaxDb; Q54J35; -.
DR EnsemblProtists; EAL63262; EAL63262; DDB_G0288331.
DR GeneID; 8626569; -.
DR KEGG; ddi:DDB_G0288331; -.
DR dictyBase; DDB_G0288331; expl7.
DR eggNOG; ENOG502T0FC; Eukaryota.
DR HOGENOM; CLU_492985_0_0_1; -.
DR InParanoid; Q54J35; -.
DR OMA; GRITYYD; -.
DR PhylomeDB; Q54J35; -.
DR PRO; PR:Q54J35; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.
DR Gene3D; 2.40.40.10; -; 1.
DR Gene3D; 2.60.40.760; -; 1.
DR InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR InterPro; IPR036749; Expansin_CBD_sf.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR036908; RlpA-like_sf.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF50685; SSF50685; 1.
DR PROSITE; PS50842; EXPANSIN_EG45; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..553
FT /note="Expansin-like protein 7"
FT /id="PRO_0000368220"
FT DOMAIN 41..139
FT /note="Expansin-like EG45"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT REGION 421..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..521
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 39
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 325
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 406
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 44..73
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT DISULFID 76..134
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
SQ SEQUENCE 553 AA; 57058 MW; 3AA573AFB1129BAD CRC64;
MRLLGSLILT LSLIASAFSS SVPLTLCMSG RAQGTESLNK SGSCEYGAYN GPTGPGTLTA
TLNEYFYSSG VKCGDCFEVS GPKGKTVVRV VNFCSAGTCP SERPLFMLTP DAFQEISSDP
LSVVYDAGFR KVSCDASGPI KAQVSEDSSK YYVKLLIFNN EVGIQSVTIK GKDMSAPVTM
VRQGSAQFVW SQAGKEMMFP ATVVVSSQYG GSVTMTMNSL SMDILKFSGN FVAPKSSIIK
NAPASCSLSA SPLAIYQNGL TEGWNYWSSR SYSQINTTDS SSHSVGSTKS LSLVLMGSSS
ALTLARSGDF ETTYFTGIKF NMKANTTMSG LRVYFPNEQN KYWTPSSPIT TSWATYTVPF
TSLQHKTIES AFTFANTENI NVHINIDNIH FIASPSSVTT GYANGNETAN SGLATTTVAS
GGSGASGVAT SSHTGVSSSS STASSTASST ASSIASSTAS SSASSTSVSS TTAGGKTTSG
GSGISTSGIT GSGDSMAAST SKTTSNPTGK TTGMTGSSID HSESHSSDEH HSSSSIIKAS
LLLVSAALAF ASL
