ID   EXPL8_DICDI             Reviewed;         485 AA.
AC   Q54C80;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Expansin-like protein 8;
DE            Short=Ddexpl8;
DE   Flags: Precursor;
GN   Name=expl8; ORFNames=DDB_G0293182;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=19207182; DOI=10.1111/j.1440-169x.2009.01086.x;
RA   Ogasawara S., Shimada N., Kawata T.;
RT   "Role of an expansin-like molecule in Dictyostelium morphogenesis and
RT   regulation of its gene expression by the signal transducer and activator of
RT   transcription protein Dd-STATa.";
RL   Dev. Growth Differ. 51:109-122(2009).
CC   -!- FUNCTION: May serve to lubricate the movement of the cellulose
CC       microfibrils during cell growth and wall extension and/or may serve to
CC       maintain the fluid state of the slug cell wall. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the expansin family. Expansin A subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000199; EAL60943.1; -; Genomic_DNA.
DR   RefSeq; XP_629339.1; XM_629337.1.
DR   AlphaFoldDB; Q54C80; -.
DR   SMR; Q54C80; -.
DR   STRING; 44689.DDB0304867; -.
DR   PaxDb; Q54C80; -.
DR   EnsemblProtists; EAL60943; EAL60943; DDB_G0293182.
DR   GeneID; 8629063; -.
DR   KEGG; ddi:DDB_G0293182; -.
DR   dictyBase; DDB_G0293182; expl8.
DR   HOGENOM; CLU_038219_0_0_1; -.
DR   InParanoid; Q54C80; -.
DR   OMA; SECTKAR; -.
DR   PhylomeDB; Q54C80; -.
DR   PRO; PR:Q54C80; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.40.10; -; 1.
DR   InterPro; IPR007112; Expansin/allergen_DPBB_dom.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
DR   PROSITE; PS50842; EXPANSIN_EG45; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Glycoprotein; Membrane; Reference proteome; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..485
FT                   /note="Expansin-like protein 8"
FT                   /id="PRO_0000383953"
FT   TOPO_DOM        22..464
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          26..139
FT                   /note="Expansin-like EG45"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT   REGION          408..436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        117
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        365
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        454
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..70
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
FT   DISULFID        73..134
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00079"
SQ   SEQUENCE   485 AA;  52470 MW;  11F814EF75E553EF CRC64;
     MRISIILLSL LFLSLHSLIK ADITKLSVCG SARAVPTATQ NPKPTCVNVN SQGIPTAGLN
     SAAFDNGVRC GQCYELTGPL GKTVVMVADV CDAGSACTQS DLFNFIIPNE EFDKIGNRSD
     YGNIFSLCYQ IVSCGYSGNV QGVFTGPSSS PNTFTYFLSV VFSNNNVAIK KVLIKGLSWP
     LYESLTGQNG NWKWNKNSYE LQFPATLYIT SNTGETITYK MNSRPITNQP IDLDFQFNPK
     AISSLENNEC SMALLPQYIY QDGLSYGWVD SQSFNYAKFT DKSSDTKSGS GTCINAQLDG
     HGGVKFTREG DFQTSYLDKL SFDIKTSADS SSFAVYFGDV ATKNIDPLVA STWTTVELSV
     KSLTNNTVEG SITFFNNQAD PINIWLDNIK WTYTDDAPLD QPTMDLIEVN NKPSTTSGTG
     TTSSKPSSSS GGVSGGGIGS ESSIYGLSSE NQENQSGHHA SSNTNILLPT TFVFFISITI
     LSLLF