ID   EXPR_DICD3              Reviewed;         250 AA.
AC   Q47188; E0SME7;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Transcriptional activator protein ExpR;
GN   Name=expR; OrderedLocusNames=Dda3937_03218;
OS   Dickeya dadantii (strain 3937) (Erwinia chrysanthemi (strain 3937)).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=198628;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=3937;
RX   PubMed=9781877; DOI=10.1046/j.1365-2958.1998.01022.x;
RA   Nasser W., Bouillant M.L., Salmond G., Reverchon S.;
RT   "Characterization of the Erwinia chrysanthemi expI-expR locus directing the
RT   synthesis of two N-acyl-homoserine lactone signal molecules.";
RL   Mol. Microbiol. 29:1391-1405(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3937;
RX   PubMed=21217001; DOI=10.1128/jb.01513-10;
RA   Glasner J.D., Yang C.H., Reverchon S., Hugouvieux-Cotte-Pattat N.,
RA   Condemine G., Bohin J.P., Van Gijsegem F., Yang S., Franza T., Expert D.,
RA   Plunkett G. III, San Francisco M.J., Charkowski A.O., Py B., Bell K.,
RA   Rauscher L., Rodriguez-Palenzuela P., Toussaint A., Holeva M.C., He S.Y.,
RA   Douet V., Boccara M., Blanco C., Toth I., Anderson B.D., Biehl B.S.,
RA   Mau B., Flynn S.M., Barras F., Lindeberg M., Birch P.R., Tsuyumu S.,
RA   Shi X., Hibbing M., Yap M.N., Carpentier M., Dassa E., Umehara M.,
RA   Kim J.F., Rusch M., Soni P., Mayhew G.F., Fouts D.E., Gill S.R.,
RA   Blattner F.R., Keen N.T., Perna N.T.;
RT   "Genome sequence of the plant-pathogenic bacterium Dickeya dadantii 3937.";
RL   J. Bacteriol. 193:2076-2077(2011).
CC   -!- FUNCTION: Functions as an OHLL responsive transcriptional regulator
CC       that acts in virulence (soft rot disease) through the activation of
CC       genes for plant tissue macerating enzymes.
CC   -!- SIMILARITY: Belongs to the autoinducer-regulated transcriptional
CC       regulatory protein family. {ECO:0000305}.
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DR   EMBL; X96440; CAA65307.1; -; Genomic_DNA.
DR   EMBL; CP002038; ADN00586.1; -; Genomic_DNA.
DR   RefSeq; WP_013319981.1; NC_014500.1.
DR   AlphaFoldDB; Q47188; -.
DR   SMR; Q47188; -.
DR   STRING; 198628.Dda3937_03218; -.
DR   EnsemblBacteria; ADN00586; ADN00586; Dda3937_03218.
DR   GeneID; 9735887; -.
DR   KEGG; ddd:Dda3937_03218; -.
DR   PATRIC; fig|198628.6.peg.4339; -.
DR   eggNOG; COG2771; Bacteria.
DR   HOGENOM; CLU_072786_5_0_6; -.
DR   OMA; NFHIRSV; -.
DR   OrthoDB; 1687028at2; -.
DR   BioCyc; DDAD198628:DDA3937_RS20730-MON; -.
DR   Proteomes; UP000006859; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 3.30.450.80; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR005143; TF_LuxR_autoind-bd_dom.
DR   InterPro; IPR036693; TF_LuxR_autoind-bd_dom_sf.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03472; Autoind_bind; 1.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF75516; SSF75516; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Quorum sensing; Reference proteome; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..250
FT                   /note="Transcriptional activator protein ExpR"
FT                   /id="PRO_0000184153"
FT   DOMAIN          173..238
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        197..216
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   CONFLICT        116
FT                   /note="D -> S (in Ref. 1; CAA65307)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   250 AA;  28716 MW;  48B86236007352FD CRC64;
     MSISFSNVDF INSTIQSYLN RKLKSYGDPK YAYLIMNKKK PTDVVIISNY PTEWVDIYRN
     NNYQHIDPVI LTAINKISPF SWDDDLVISS KLKFSRIFNL SKDYDIVNGY TFVLHDPGNN
     LAALSFMIEE HRSEELEEII QNNKDKLQML LISAHEKLTS LYREMSRNRN NSKSQEADLF
     SQRENEILHW ASMGKTYQEI ALILGITTST VKFHIGNVVK KLGVLNAKHA IRLGVEMNLI
     KPVGPAKARS