AHL10_ARATH
ID AHL10_ARATH Reviewed; 351 AA.
AC O22812; O23142; Q94F52;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 2.
DT 25-MAY-2022, entry version 138.
DE RecName: Full=AT-hook motif nuclear-localized protein 10 {ECO:0000312|EMBL:FAA00281.1};
DE AltName: Full=AT-hook protein 1 {ECO:0000312|EMBL:CAA10857.1};
GN Name=AHL10 {ECO:0000303|PubMed:15604740};
GN Synonyms=AHP1 {ECO:0000303|Ref.1};
GN OrderedLocusNames=At2g33620 {ECO:0000312|Araport:AT2G33620};
GN ORFNames=F4P9.39 {ECO:0000312|EMBL:AAB80677.2};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Landsberg erecta;
RC TISSUE=Flower bud {ECO:0000312|EMBL:CAA10857.1};
RA Hofmann W.A., Saedler H., Huijser P.;
RT "Novel AT-hook containing DNA binding protein from Arabidopsis.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP IDENTIFICATION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=15604740; DOI=10.1007/s11103-004-3249-5;
RA Fujimoto S., Matsunaga S., Yonemura M., Uchiyama S., Azuma T., Fukui K.;
RT "Identification of a novel plant MAR DNA binding protein localized on
RT chromosomal surfaces.";
RL Plant Mol. Biol. 56:225-239(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Root;
RX PubMed=18433157; DOI=10.1021/pr8000173;
RA de la Fuente van Bentem S., Anrather D., Dohnal I., Roitinger E.,
RA Csaszar E., Joore J., Buijnink J., Carreri A., Forzani C., Lorkovic Z.J.,
RA Barta A., Lecourieux D., Verhounig A., Jonak C., Hirt H.;
RT "Site-specific phosphorylation profiling of Arabidopsis proteins by mass
RT spectrometry and peptide chip analysis.";
RL J. Proteome Res. 7:2458-2470(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
RN [8]
RP GENE FAMILY, AND DOMAIN PPC.
RX PubMed=24218605; DOI=10.1073/pnas.1219277110;
RA Zhao J., Favero D.S., Peng H., Neff M.M.;
RT "Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by
RT interacting with each other via the PPC/DUF296 domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E4688-E4697(2013).
CC -!- FUNCTION: Transcription factor that specifically binds AT-rich DNA
CC sequences related to the nuclear matrix attachment regions (MARs).
CC {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- DOMAIN: The PPC domain mediates interactions between AHL proteins.
CC {ECO:0000269|PubMed:24218605}.
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DR EMBL; AJ222585; CAA10857.1; -; mRNA.
DR EMBL; AC002332; AAB80677.2; -; Genomic_DNA.
DR EMBL; CP002685; AEC08860.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08861.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08862.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08863.1; -; Genomic_DNA.
DR EMBL; AF385705; AAK60297.1; -; mRNA.
DR EMBL; AY081729; AAL87382.1; -; mRNA.
DR EMBL; BR000346; FAA00281.1; -; mRNA.
DR PIR; G84747; G84747.
DR RefSeq; NP_001118437.1; NM_001124965.1.
DR RefSeq; NP_565769.1; NM_128922.3.
DR RefSeq; NP_850215.1; NM_179884.4.
DR RefSeq; NP_973590.1; NM_201861.3.
DR AlphaFoldDB; O22812; -.
DR SMR; O22812; -.
DR STRING; 3702.AT2G33620.2; -.
DR iPTMnet; O22812; -.
DR PaxDb; O22812; -.
DR PRIDE; O22812; -.
DR ProteomicsDB; 245033; -.
DR EnsemblPlants; AT2G33620.1; AT2G33620.1; AT2G33620.
DR EnsemblPlants; AT2G33620.2; AT2G33620.2; AT2G33620.
DR EnsemblPlants; AT2G33620.3; AT2G33620.3; AT2G33620.
DR EnsemblPlants; AT2G33620.4; AT2G33620.4; AT2G33620.
DR GeneID; 817928; -.
DR Gramene; AT2G33620.1; AT2G33620.1; AT2G33620.
DR Gramene; AT2G33620.2; AT2G33620.2; AT2G33620.
DR Gramene; AT2G33620.3; AT2G33620.3; AT2G33620.
DR Gramene; AT2G33620.4; AT2G33620.4; AT2G33620.
DR KEGG; ath:AT2G33620; -.
DR Araport; AT2G33620; -.
DR TAIR; locus:2051038; AT2G33620.
DR eggNOG; ENOG502QSB3; Eukaryota.
DR HOGENOM; CLU_039808_7_0_1; -.
DR InParanoid; O22812; -.
DR OMA; MNMGSEP; -.
DR OrthoDB; 1133947at2759; -.
DR PhylomeDB; O22812; -.
DR PRO; PR:O22812; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22812; baseline and differential.
DR Genevisible; O22812; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IEA:InterPro.
DR CDD; cd11378; DUF296; 1.
DR InterPro; IPR039605; AHL.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR005175; PPC_dom.
DR PANTHER; PTHR31500; PTHR31500; 1.
DR Pfam; PF03479; PCC; 1.
DR SMART; SM00384; AT_hook; 2.
DR PROSITE; PS51742; PPC; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation.
FT CHAIN 1..351
FT /note="AT-hook motif nuclear-localized protein 10"
FT /id="PRO_0000432028"
FT DOMAIN 159..301
FT /note="PPC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01078"
FT DNA_BIND 97..109
FT /note="A.T hook 1"
FT /evidence="ECO:0000255"
FT DNA_BIND 138..149
FT /note="A.T hook 2"
FT /evidence="ECO:0000255"
FT REGION 1..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 310..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 97..105
FT /note="Bipartite nuclear localization signal"
FT /evidence="ECO:0000305"
FT COMPBIAS 1..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 154
FT /note="Q -> E (in Ref. 1; CAA10857)"
FT /evidence="ECO:0000305"
FT CONFLICT 208
FT /note="S -> P (in Ref. 4; AAK60297)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 351 AA; 36317 MW; C52A5414FFB9DE65 CRC64;
MSGSETGLMA ATRESMQFTM ALHQQQQHSQ AQPQQSQNRP LSFGGDDGTA LYKQPMRSVS
PPQQYQPNSA GENSVLNMNL PGGESGGMTG TGSEPVKKRR GRPRKYGPDS GEMSLGLNPG
APSFTVSQPS SGGDGGEKKR GRPPGSSSKR LKLQALGSTG IGFTPHVLTV LAGEDVSSKI
MALTHNGPRA VCVLSANGAI SNVTLRQSAT SGGTVTYEGR FEILSLSGSF HLLENNGQRS
RTGGLSVSLS SPDGNVLGGS VAGLLIAASP VQIVVGSFLP DGEKEPKQHV GQMGLSSPVL
PRVAPTQVLM TPSSPQSRGT MSESSCGGGH GSPIHQSTGG PYNNTINMPW K
