EXU1_DROPS
ID EXU1_DROPS Reviewed; 495 AA.
AC Q24618; Q28ZQ1; Q8STA2;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Maternal protein exuperantia-1;
GN Name=exu1; ORFNames=GA21461;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8070663; DOI=10.1093/genetics/137.2.521;
RA Luk S.K.-S., Kilpatrick M., Kerr K., Macdonald P.M.;
RT "Components acting in localization of bicoid mRNA are conserved among
RT Drosophila species.";
RL Genetics 137:521-530(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-124.
RX PubMed=12824467; DOI=10.1073/pnas.1432900100;
RA Schaeffer S.W., Goetting-Minesky M.P., Kovacevic M., Peoples J.R.,
RA Graybill J.L., Miller J.M., Kim K., Nelson J.G., Anderson W.W.;
RT "Evolutionary genomics of inversions in Drosophila pseudoobscura: evidence
RT for epistasis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:8319-8324(2003).
CC -!- FUNCTION: Ensures the proper localization of the mRNA of the bicoid
CC gene to the anterior regions of the oocyte thus playing a fundamental
CC role in the establishment of the polarity of the oocyte. May bind the
CC bcd mRNA (By similarity). {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EAL25562.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; L22554; AAA28524.1; -; Genomic_DNA.
DR EMBL; CM000071; EAL25562.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AF476528; AAL91372.1; -; Genomic_DNA.
DR EMBL; AF476529; AAL91373.1; -; Genomic_DNA.
DR EMBL; AF476530; AAL91374.1; -; Genomic_DNA.
DR EMBL; AF476531; AAL91375.1; -; Genomic_DNA.
DR EMBL; AF476532; AAL91376.1; -; Genomic_DNA.
DR EMBL; AF476533; AAL91377.1; -; Genomic_DNA.
DR EMBL; AF476534; AAL91378.1; -; Genomic_DNA.
DR EMBL; AF476535; AAL91379.1; -; Genomic_DNA.
DR EMBL; AF476536; AAL91380.1; -; Genomic_DNA.
DR EMBL; AF476537; AAL91381.1; -; Genomic_DNA.
DR EMBL; AF476538; AAL91382.1; -; Genomic_DNA.
DR EMBL; AF476539; AAL91383.1; -; Genomic_DNA.
DR EMBL; AF476540; AAL91384.1; -; Genomic_DNA.
DR EMBL; AF476541; AAL91385.1; -; Genomic_DNA.
DR EMBL; AF476542; AAL91386.1; -; Genomic_DNA.
DR EMBL; AF476543; AAL91387.1; -; Genomic_DNA.
DR EMBL; AF476544; AAL91388.1; -; Genomic_DNA.
DR EMBL; AF476545; AAL91389.1; -; Genomic_DNA.
DR EMBL; AF476546; AAL91390.1; -; Genomic_DNA.
DR EMBL; AF476547; AAL91391.1; -; Genomic_DNA.
DR EMBL; AF476548; AAL91392.1; -; Genomic_DNA.
DR EMBL; AF476549; AAL91393.1; -; Genomic_DNA.
DR EMBL; AF476550; AAL91394.1; -; Genomic_DNA.
DR EMBL; AF476551; AAL91395.1; -; Genomic_DNA.
DR EMBL; AF476552; AAL91396.1; -; Genomic_DNA.
DR EMBL; AF476553; AAL91397.1; -; Genomic_DNA.
DR EMBL; AF476554; AAL91398.1; -; Genomic_DNA.
DR EMBL; AF476555; AAL91399.1; -; Genomic_DNA.
DR EMBL; AF476556; AAL91400.1; -; Genomic_DNA.
DR EMBL; AF476557; AAL91401.1; -; Genomic_DNA.
DR EMBL; AF476558; AAL91402.1; -; Genomic_DNA.
DR EMBL; AF476559; AAL91403.1; -; Genomic_DNA.
DR EMBL; AF476560; AAL91404.1; -; Genomic_DNA.
DR EMBL; AF476561; AAL91405.1; -; Genomic_DNA.
DR EMBL; AF476562; AAL91406.1; -; Genomic_DNA.
DR EMBL; AF476563; AAL91407.1; -; Genomic_DNA.
DR EMBL; AF476564; AAL91408.1; -; Genomic_DNA.
DR EMBL; AF476565; AAL91409.1; -; Genomic_DNA.
DR EMBL; AF476566; AAL91410.1; -; Genomic_DNA.
DR EMBL; AF476567; AAL91411.1; -; Genomic_DNA.
DR EMBL; AF476568; AAL91412.1; -; Genomic_DNA.
DR EMBL; AF476569; AAL91413.1; -; Genomic_DNA.
DR EMBL; AF476570; AAL91414.1; -; Genomic_DNA.
DR EMBL; AF476571; AAL91415.1; -; Genomic_DNA.
DR EMBL; AF476572; AAL91416.1; -; Genomic_DNA.
DR EMBL; AF476573; AAL91417.1; -; Genomic_DNA.
DR EMBL; AF476574; AAL91418.1; -; Genomic_DNA.
DR EMBL; AF476575; AAL91419.1; -; Genomic_DNA.
DR EMBL; AF476576; AAL91420.1; -; Genomic_DNA.
DR EMBL; AF476577; AAL91421.1; -; Genomic_DNA.
DR EMBL; AF476578; AAL91422.1; -; Genomic_DNA.
DR EMBL; AF476579; AAL91423.1; -; Genomic_DNA.
DR EMBL; AF476580; AAL91424.1; -; Genomic_DNA.
DR EMBL; AF476581; AAL91425.1; -; Genomic_DNA.
DR EMBL; AF476582; AAL91426.1; -; Genomic_DNA.
DR EMBL; AF476583; AAL91427.1; -; Genomic_DNA.
DR EMBL; AF476584; AAL91428.1; -; Genomic_DNA.
DR EMBL; AF476585; AAL91429.1; -; Genomic_DNA.
DR EMBL; AF476586; AAL91430.1; -; Genomic_DNA.
DR EMBL; AF476587; AAL91431.1; -; Genomic_DNA.
DR EMBL; AF476588; AAL91432.1; -; Genomic_DNA.
DR EMBL; AF476589; AAL91433.1; -; Genomic_DNA.
DR EMBL; AF476590; AAL91434.1; -; Genomic_DNA.
DR EMBL; AF476591; AAL91435.1; -; Genomic_DNA.
DR EMBL; AF476592; AAL91436.1; -; Genomic_DNA.
DR EMBL; AF476593; AAL91437.1; -; Genomic_DNA.
DR EMBL; AF476594; AAL91438.1; -; Genomic_DNA.
DR EMBL; AF476595; AAL91439.1; -; Genomic_DNA.
DR EMBL; AF476596; AAL91440.1; -; Genomic_DNA.
DR EMBL; AF476597; AAL91441.1; -; Genomic_DNA.
DR EMBL; AF476598; AAL91442.1; -; Genomic_DNA.
DR EMBL; AF476599; AAL91443.1; -; Genomic_DNA.
DR EMBL; AF476600; AAL91444.1; -; Genomic_DNA.
DR EMBL; AF476601; AAL91445.1; -; Genomic_DNA.
DR EMBL; AF476602; AAL91446.1; -; Genomic_DNA.
DR EMBL; AF476603; AAL91447.1; -; Genomic_DNA.
DR EMBL; AF476604; AAL91448.1; -; Genomic_DNA.
DR EMBL; AF476605; AAL91449.1; -; Genomic_DNA.
DR EMBL; AF476606; AAL91450.1; -; Genomic_DNA.
DR EMBL; AF476607; AAL91451.1; -; Genomic_DNA.
DR EMBL; AF476608; AAL91452.1; -; Genomic_DNA.
DR EMBL; AF476609; AAL91453.1; -; Genomic_DNA.
DR EMBL; AF476610; AAL91454.1; -; Genomic_DNA.
DR EMBL; AF476611; AAL91455.1; -; Genomic_DNA.
DR EMBL; AF476612; AAL91456.1; -; Genomic_DNA.
DR EMBL; AF476613; AAL91457.1; -; Genomic_DNA.
DR EMBL; AF476614; AAL91458.1; -; Genomic_DNA.
DR EMBL; AF476615; AAL91459.1; -; Genomic_DNA.
DR EMBL; AF476616; AAL91460.1; -; Genomic_DNA.
DR EMBL; AF476617; AAL91461.1; -; Genomic_DNA.
DR EMBL; AF476618; AAL91462.1; -; Genomic_DNA.
DR EMBL; AF476619; AAL91463.1; -; Genomic_DNA.
DR EMBL; AF476620; AAL91464.1; -; Genomic_DNA.
DR EMBL; AF476621; AAL91465.1; -; Genomic_DNA.
DR EMBL; AF476622; AAL91466.1; -; Genomic_DNA.
DR EMBL; AF476623; AAL91467.1; -; Genomic_DNA.
DR EMBL; AF476624; AAL91468.1; -; Genomic_DNA.
DR EMBL; AF476625; AAL91469.1; -; Genomic_DNA.
DR EMBL; AF476626; AAL91470.1; -; Genomic_DNA.
DR EMBL; AF476627; AAL91471.1; -; Genomic_DNA.
DR EMBL; AF476628; AAL91472.1; -; Genomic_DNA.
DR EMBL; AF476629; AAL91473.1; -; Genomic_DNA.
DR EMBL; AF476630; AAL91474.1; -; Genomic_DNA.
DR EMBL; AF476631; AAL91475.1; -; Genomic_DNA.
DR EMBL; AF476632; AAL91476.1; -; Genomic_DNA.
DR PIR; S47890; S47890.
DR RefSeq; XP_001360986.1; XM_001360949.3.
DR RefSeq; XP_015039936.1; XM_015184450.1.
DR AlphaFoldDB; Q24618; -.
DR SMR; Q24618; -.
DR STRING; 7237.FBpp0277938; -.
DR PRIDE; Q24618; -.
DR EnsemblMetazoa; FBtr0279500; FBpp0277938; FBgn0243576.
DR EnsemblMetazoa; FBtr0367479; FBpp0330423; FBgn0243576.
DR GeneID; 4804418; -.
DR KEGG; dpo:Dpse_GA21461; -.
DR eggNOG; ENOG502QVAD; Eukaryota.
DR HOGENOM; CLU_034404_1_0_1; -.
DR InParanoid; Q24618; -.
DR OMA; FLNWLEM; -.
DR PhylomeDB; Q24618; -.
DR Proteomes; UP000001819; Chromosome 3.
DR Bgee; FBgn0243576; Expressed in male reproductive system and 2 other tissues.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045450; P:bicoid mRNA localization; IEA:InterPro.
DR InterPro; IPR037998; Exu.
DR InterPro; IPR040941; SAM_Exu.
DR PANTHER; PTHR12384; PTHR12384; 1.
DR Pfam; PF18609; SAM_Exu; 1.
PE 3: Inferred from homology;
KW Developmental protein; Reference proteome; RNA-binding.
FT CHAIN 1..495
FT /note="Maternal protein exuperantia-1"
FT /id="PRO_0000087143"
FT REGION 197..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 427..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 229
FT /note="D -> N (in Ref. 1; AAA28524)"
FT /evidence="ECO:0000305"
FT CONFLICT 424
FT /note="T -> S (in Ref. 1; AAA28524)"
FT /evidence="ECO:0000305"
FT CONFLICT 458
FT /note="G -> S (in Ref. 1; AAA28524)"
FT /evidence="ECO:0000305"
FT CONFLICT 477
FT /note="E -> ESL (in Ref. 1; AAA28524)"
FT /evidence="ECO:0000305"
FT CONFLICT 486
FT /note="S -> A (in Ref. 1; AAA28524)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 495 AA; 55039 MW; D56DCDB8F12C4129 CRC64;
MVAEISKDCV TIAAADQCVD MKEELPAGNY ILVGVDVDTT GRRLIDEIVQ LAAYTPKDNF
QQYIMPYMNL NPAARQRHQI RVISIGFYRM LKSMQTYKII KSKSEVAALM DFLNWLEMLV
AKQPSTDGIV MLYHEERKFI PYMVLEALKK YGLIERFNRT VKSFVNTFNM AKASLGDANL
KNCGLRKLSL LLAKSNDESA NKENEPENVN RNGSSNDKCH KNGMNQEHDF FEGSANVRAK
MVYEVALQLT NSDRTSEPES SEELVNLFNA VKPFAKLVSS DIMELQTQNE NMGRQNSFRP
VFLNYFRTTL YHRVRAVKFR IVLAENGFTL DSLKAIWTEK RKEGLELALT NIDTLKTEEK
TELVELLDSF FDPSKATIKP SFKPNGNGPR RRIRANGAAS SKNGAMSSRS TSTEFGAGGD
KSQTEGLSAP VPDSTTKSPS PGKTGGRPHR KRNNTRNGFG SAKGPKKAET LNIAAPEPPQ
SPVAVSTPVA IAATN
