EXU2_DROPS
ID EXU2_DROPS Reviewed; 477 AA.
AC Q24617; Q7YSK7; Q7YSK9; Q7YSR3; Q7YXI5; Q7YXI6; Q7YXI7; Q7YXI8;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Maternal protein exuperantia-2;
GN Name=exu2;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8070663; DOI=10.1093/genetics/137.2.521;
RA Luk S.K.-S., Kilpatrick M., Kerr K., Macdonald P.M.;
RT "Components acting in localization of bicoid mRNA are conserved among
RT Drosophila species.";
RL Genetics 137:521-530(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 65-388.
RC STRAIN=afc1, afc3, afc7, f17, f20, jr10, jr274, m32, m48, m52, msh15, msh2,
RC msh37, msh9, ps1, ps10, ps11, ps12, ps13, ps14, ps15, ps16, ps17, ps18,
RC ps2, ps3, ps4, ps5, ps7, ps8, and ps9;
RX PubMed=14768894; DOI=10.1017/s0016672303006402;
RA Yi S., Charlesworth B.;
RT "Unusual pattern of single nucleotide polymorphism at the exuperantia2
RT locus of Drosophila pseudoobscura.";
RL Genet. Res. 82:101-106(2003).
CC -!- FUNCTION: Ensures the proper localization of the mRNA of the bicoid
CC gene to the anterior regions of the oocyte thus playing a fundamental
CC role in the establishment of the polarity of the oocyte. May bind the
CC bcd mRNA (By similarity). {ECO:0000250}.
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DR EMBL; L22553; AAA28523.1; -; Genomic_DNA.
DR EMBL; CH379064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY337547; AAP97898.1; -; Genomic_DNA.
DR EMBL; AY337548; AAP97899.1; -; Genomic_DNA.
DR EMBL; AY337549; AAP97900.1; -; Genomic_DNA.
DR EMBL; AY337550; AAP97901.1; -; Genomic_DNA.
DR EMBL; AY337551; AAP97902.1; -; Genomic_DNA.
DR EMBL; AY337552; AAP97903.1; -; Genomic_DNA.
DR EMBL; AY337553; AAP97904.1; -; Genomic_DNA.
DR EMBL; AY337554; AAP97905.1; -; Genomic_DNA.
DR EMBL; AY337555; AAP97906.1; -; Genomic_DNA.
DR EMBL; AY337556; AAP97907.1; -; Genomic_DNA.
DR EMBL; AY337557; AAP97908.1; -; Genomic_DNA.
DR EMBL; AY337558; AAP97909.1; -; Genomic_DNA.
DR EMBL; AY337559; AAP97910.1; -; Genomic_DNA.
DR EMBL; AY337560; AAP97911.1; -; Genomic_DNA.
DR EMBL; AY337561; AAP97912.1; -; Genomic_DNA.
DR EMBL; AY337562; AAP97913.1; -; Genomic_DNA.
DR EMBL; AY337563; AAP97914.1; -; Genomic_DNA.
DR EMBL; AY337564; AAP97915.1; -; Genomic_DNA.
DR EMBL; AY337565; AAP97916.1; -; Genomic_DNA.
DR EMBL; AY337566; AAP97917.1; -; Genomic_DNA.
DR EMBL; AY337567; AAP97918.1; -; Genomic_DNA.
DR EMBL; AY337568; AAP97919.1; -; Genomic_DNA.
DR EMBL; AY337569; AAP97920.1; -; Genomic_DNA.
DR EMBL; AY337570; AAP97921.1; -; Genomic_DNA.
DR EMBL; AY337571; AAP97922.1; -; Genomic_DNA.
DR EMBL; AY337572; AAP97923.1; -; Genomic_DNA.
DR EMBL; AY337573; AAP97924.1; -; Genomic_DNA.
DR EMBL; AY337574; AAP97925.1; -; Genomic_DNA.
DR EMBL; AY337575; AAP97926.1; -; Genomic_DNA.
DR EMBL; AY337576; AAP97927.1; -; Genomic_DNA.
DR EMBL; AY337577; AAP97928.1; -; Genomic_DNA.
DR PIR; S47889; S47889.
DR AlphaFoldDB; Q24617; -.
DR SMR; Q24617; -.
DR STRING; 7237.FBpp0286361; -.
DR eggNOG; ENOG502QVAD; Eukaryota.
DR InParanoid; Q24617; -.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0045450; P:bicoid mRNA localization; IEA:InterPro.
DR InterPro; IPR037998; Exu.
DR InterPro; IPR040941; SAM_Exu.
DR PANTHER; PTHR12384; PTHR12384; 1.
DR Pfam; PF18609; SAM_Exu; 1.
PE 3: Inferred from homology;
KW Developmental protein; Reference proteome; RNA-binding.
FT CHAIN 1..477
FT /note="Maternal protein exuperantia-2"
FT /id="PRO_0000087144"
FT REGION 196..226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 440..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 220
FT /note="G -> S (in strain: msh9)"
FT VARIANT 221
FT /note="H -> P (in strain: afc1, afc7, f17, m32, msh9,
FT msh37, ps1, ps2, ps3, ps9, ps10, ps11, ps12, ps14 and
FT ps15)"
FT VARIANT 267
FT /note="S -> T (in strain: m32, msh37, ps14 and ps15)"
FT VARIANT 289
FT /note="I -> V (in strain: afc1, m32, msh37, ps14 and ps15)"
FT VARIANT 315
FT /note="T -> A (in strain: ps4)"
FT VARIANT 367
FT /note="T -> A (in strain: f17)"
FT VARIANT 382
FT /note="K -> R (in strain: f17)"
FT CONFLICT 329
FT /note="G -> A (in Ref. 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 477 AA; 53195 MW; 8B5334A77DB9467B CRC64;
MVSAISEDSA SATASGQCEV VKEELPAGNY ILVAVEIDTT GRRLIDEIVQ LAGYTSKGNF
QQYIMPYMNL NQAARQRHQI RVISIGFYRM LKSMQTYKII KSKSEVAALM DFLNWLETLL
AKQPNKEGIV MLYHDDRKFI PYMILEALKK YSLIDRFNRS VKAFANTCPM AKTFLGKHGI
KNCGLRKLSM LLAKSKDGNS TKEDEHENPE GNSSITDNSG HKNQKQGAFE GSANVRAKMV
YEMALQLIES ESTESPESFE SPESSESSEA EVKLLNAVRP FSQLLSSTIL ELKDQNHSLG
RQNSFRPVFL NYFRTTLNYR VRAVKYRIGL AEHGFTLKSL KAIWSDKRKP GLELVLTAID
SLKTEETAEL LDLLDSYYDP SKTTIKPRCK RSGNGTRRRN RAKGAASSKN GAIGAGGDNS
VPDSATKPGG RPRRKRNNIR NNILGPQNTE KGSPKAEMKT STPKSMSIKP PSEFADI
