EXUR_BACSU
ID EXUR_BACSU Reviewed; 333 AA.
AC Q9JMQ1; Q796M9;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Probable HTH-type transcriptional repressor ExuR;
DE AltName: Full=Probable galacturonate locus repressor;
GN Name=exuR; Synonyms=yjmH; OrderedLocusNames=BSU12370;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROBABLE OPERON STRUCTURE.
RC STRAIN=168;
RX PubMed=9579062; DOI=10.1099/00221287-144-4-877;
RA Rivolta C., Soldo B., Lazarevic V., Joris B., Mauel C., Karamata D.;
RT "A 35.7 kb DNA fragment from the Bacillus subtilis chromosome containing a
RT putative 12.3 kb operon involved in hexuronate catabolism and a perfectly
RT symmetrical hypothetical catabolite-responsive element.";
RL Microbiology 144:877-884(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP DISRUPTION PHENOTYPE, PROBABLE OPERON STRUCTURE, AND INDUCTION.
RC STRAIN=168 / MB24;
RX PubMed=9882655; DOI=10.1128/jb.181.2.426-433.1999;
RA Mekjian K.R., Bryan E.M., Beall B.W., Moran C.P. Jr.;
RT "Regulation of hexuronate utilization in Bacillus subtilis.";
RL J. Bacteriol. 181:426-433(1999).
CC -!- FUNCTION: Transcriptional repressor for the exu locus which is required
CC for galacturonate utilization. {ECO:0000305}.
CC -!- INDUCTION: Induced by galacturonate, repressed by glucose.
CC {ECO:0000305|PubMed:9882655}.
CC -!- DISRUPTION PHENOTYPE: Cells lacking this gene express the exu locus
CC genes (required for hexuronate utilization) constitutively. Its absence
CC additionally confers the ability to grow on minimal medium plus
CC glucuronate, which cells cannot do in the presence of ExuR.
CC {ECO:0000269|PubMed:9882655}.
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DR EMBL; AF015825; AAC46333.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB13094.1; -; Genomic_DNA.
DR PIR; B69853; B69853.
DR RefSeq; NP_389119.1; NC_000964.3.
DR RefSeq; WP_003244946.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; Q9JMQ1; -.
DR SMR; Q9JMQ1; -.
DR STRING; 224308.BSU12370; -.
DR jPOST; Q9JMQ1; -.
DR PaxDb; Q9JMQ1; -.
DR PRIDE; Q9JMQ1; -.
DR EnsemblBacteria; CAB13094; CAB13094; BSU_12370.
DR GeneID; 939834; -.
DR KEGG; bsu:BSU12370; -.
DR PATRIC; fig|224308.179.peg.1338; -.
DR eggNOG; COG1609; Bacteria.
DR InParanoid; Q9JMQ1; -.
DR OMA; EAPYDHI; -.
DR PhylomeDB; Q9JMQ1; -.
DR BioCyc; BSUB:BSU12370-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd01392; HTH_LacI; 1.
DR Gene3D; 1.10.260.40; -; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR PRINTS; PR00036; HTHLACI.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; SSF47413; 1.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..333
FT /note="Probable HTH-type transcriptional repressor ExuR"
FT /id="PRO_0000359946"
FT DOMAIN 2..56
FT /note="HTH lacI-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
FT DNA_BIND 4..23
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00111"
SQ SEQUENCE 333 AA; 37381 MW; E4A275C36E0D0B81 CRC64;
MVTIKDIAKL ANVSHTTVSR ALNNSPYIKE HTKKKILELA EQLNYTPNVN AKSLAMQKSH
TIGLFFTSIT NGTSHSFFAD TIKGVNQAIS EDYNLYVRGI DDLKNYDSVT PMRYDGIILM
SQSDIDNSFI YHIREKNIPL VVLNRDIDDR TITNILSNDK EGSQEAVEYF IQSGHQDIAI
IEGIEGFKSS QQRKEGYLSA LIQHHIPIKH EYSVKGQYDM ESGFQAMERL LALPNPPTAV
FCSNDDMAIG AMNAIFAKGL RVPDDISVIG FDDIGFSQYI TPRLSTVKRP VEKISVLGAQ
KLLSLISEPE TKAEKILENT EFMVRDSVRR LTT