ID   EXUR_ECO57              Reviewed;         258 AA.
AC   P0ACL3; P42608; P76665; Q8X4Y9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Exu regulon transcriptional regulator;
GN   Name=exuR; OrderedLocusNames=Z4448, ECs3976;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
CC   -!- FUNCTION: Repressor for the exu regulon that encode genes involved in
CC       hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB
CC       operons. Binds D-tagaturonate and D-fructuronate as inducers (By
CC       similarity). {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG58227.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAB37399.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE005174; AAG58227.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BA000007; BAB37399.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_312003.2; NC_002695.1.
DR   RefSeq; WP_000406488.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; P0ACL3; -.
DR   SMR; P0ACL3; -.
DR   STRING; 155864.EDL933_4316; -.
DR   EnsemblBacteria; AAG58227; AAG58227; Z4448.
DR   EnsemblBacteria; BAB37399; BAB37399; ECs_3976.
DR   GeneID; 66673003; -.
DR   GeneID; 916189; -.
DR   KEGG; ece:Z4448; -.
DR   KEGG; ecs:ECs_3976; -.
DR   PATRIC; fig|386585.9.peg.4150; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_5_6; -.
DR   OMA; TWQEHRK; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..258
FT                   /note="Exu regulon transcriptional regulator"
FT                   /id="PRO_0000050623"
FT   DOMAIN          7..75
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        35..54
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   258 AA;  29836 MW;  689758815BC501FD CRC64;
     MEITEPRRLY QQLAADLKER IEQGVYLVGD KLPAERFIAD EKNVSRTVVR EAIIMLEVEG
     YVEVRKGSGI HVVSNQPRHQ QAADNNMEFA NYGPFELLQA RQLIESNIAE FAATQVTKQD
     IMKLMAIQEQ ARGEQCFRDS EWDLQFHIQV ALATQNSALA AIVEKMWTQR SHNPYWKKLH
     EHIDSRTVDN WCDDHDQILK ALIRKDPHAA KLAMWQHLEN TKIMLFNETS DDFEFNADRY
     LFAENPVVHL DTATSGSK