ID   EXUR_ECOLI              Reviewed;         258 AA.
AC   P0ACL2; P42608; P76665; Q2M9B2; Q8X4Y9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Exu regulon transcriptional regulator;
GN   Name=exuR; OrderedLocusNames=b3094, JW3065;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RA   Mizobuchi K.;
RL   Submitted (SEP-1992) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
CC   -!- FUNCTION: Repressor for the exu regulon that encode genes involved in
CC       hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB
CC       operons. Binds D-tagaturonate and D-fructuronate as inducers.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAA57898.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; D13328; BAA02589.1; -; Genomic_DNA.
DR   EMBL; U18997; AAA57898.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC76129.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE77144.1; -; Genomic_DNA.
DR   PIR; C65098; C65098.
DR   RefSeq; NP_417565.2; NC_000913.3.
DR   RefSeq; WP_000406488.1; NZ_STEB01000001.1.
DR   AlphaFoldDB; P0ACL2; -.
DR   SMR; P0ACL2; -.
DR   BioGRID; 4262410; 10.
DR   IntAct; P0ACL2; 3.
DR   STRING; 511145.b3094; -.
DR   jPOST; P0ACL2; -.
DR   PaxDb; P0ACL2; -.
DR   PRIDE; P0ACL2; -.
DR   EnsemblBacteria; AAC76129; AAC76129; b3094.
DR   EnsemblBacteria; BAE77144; BAE77144; BAE77144.
DR   GeneID; 66673003; -.
DR   GeneID; 947602; -.
DR   KEGG; ecj:JW3065; -.
DR   KEGG; eco:b3094; -.
DR   PATRIC; fig|511145.12.peg.3189; -.
DR   EchoBASE; EB2595; -.
DR   eggNOG; COG2186; Bacteria.
DR   HOGENOM; CLU_017584_9_5_6; -.
DR   InParanoid; P0ACL2; -.
DR   OMA; TWQEHRK; -.
DR   PhylomeDB; P0ACL2; -.
DR   BioCyc; EcoCyc:PD03270; -.
DR   PRO; PR:P0ACL2; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:EcoCyc.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..258
FT                   /note="Exu regulon transcriptional regulator"
FT                   /id="PRO_0000050622"
FT   DOMAIN          7..75
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        35..54
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   258 AA;  29836 MW;  689758815BC501FD CRC64;
     MEITEPRRLY QQLAADLKER IEQGVYLVGD KLPAERFIAD EKNVSRTVVR EAIIMLEVEG
     YVEVRKGSGI HVVSNQPRHQ QAADNNMEFA NYGPFELLQA RQLIESNIAE FAATQVTKQD
     IMKLMAIQEQ ARGEQCFRDS EWDLQFHIQV ALATQNSALA AIVEKMWTQR SHNPYWKKLH
     EHIDSRTVDN WCDDHDQILK ALIRKDPHAA KLAMWQHLEN TKIMLFNETS DDFEFNADRY
     LFAENPVVHL DTATSGSK