ID   EXUR_SHIFL              Reviewed;         258 AA.
AC   P0ACL4; P42608; P76665; Q8X4Y9;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Exu regulon transcriptional regulator;
GN   Name=exuR; OrderedLocusNames=SF3137, S3345;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- FUNCTION: Repressor for the exu regulon that encode genes involved in
CC       hexuronate utilization. It regulates the ExuT, UxaCA and UxuRAB
CC       operons. Binds D-tagaturonate and D-fructuronate as inducers (By
CC       similarity). {ECO:0000250}.
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DR   EMBL; AE005674; AAN44609.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18423.1; -; Genomic_DNA.
DR   RefSeq; NP_708902.1; NC_004337.2.
DR   RefSeq; WP_000406488.1; NZ_WPGW01000077.1.
DR   AlphaFoldDB; P0ACL4; -.
DR   SMR; P0ACL4; -.
DR   STRING; 198214.SF3137; -.
DR   PRIDE; P0ACL4; -.
DR   EnsemblBacteria; AAN44609; AAN44609; SF3137.
DR   EnsemblBacteria; AAP18423; AAP18423; S3345.
DR   GeneID; 1026725; -.
DR   GeneID; 66673003; -.
DR   KEGG; sfl:SF3137; -.
DR   KEGG; sfx:S3345; -.
DR   PATRIC; fig|198214.7.peg.3724; -.
DR   HOGENOM; CLU_017584_9_5_6; -.
DR   OMA; TWQEHRK; -.
DR   OrthoDB; 1875458at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   CDD; cd07377; WHTH_GntR; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.20.120.530; -; 1.
DR   InterPro; IPR011711; GntR_C.
DR   InterPro; IPR008920; TF_FadR/GntR_C.
DR   InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF07729; FCD; 1.
DR   Pfam; PF00392; GntR; 1.
DR   PRINTS; PR00035; HTHGNTR.
DR   SMART; SM00895; FCD; 1.
DR   SMART; SM00345; HTH_GNTR; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF48008; SSF48008; 1.
DR   PROSITE; PS50949; HTH_GNTR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..258
FT                   /note="Exu regulon transcriptional regulator"
FT                   /id="PRO_0000050624"
FT   DOMAIN          7..75
FT                   /note="HTH gntR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
FT   DNA_BIND        35..54
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00307"
SQ   SEQUENCE   258 AA;  29836 MW;  689758815BC501FD CRC64;
     MEITEPRRLY QQLAADLKER IEQGVYLVGD KLPAERFIAD EKNVSRTVVR EAIIMLEVEG
     YVEVRKGSGI HVVSNQPRHQ QAADNNMEFA NYGPFELLQA RQLIESNIAE FAATQVTKQD
     IMKLMAIQEQ ARGEQCFRDS EWDLQFHIQV ALATQNSALA AIVEKMWTQR SHNPYWKKLH
     EHIDSRTVDN WCDDHDQILK ALIRKDPHAA KLAMWQHLEN TKIMLFNETS DDFEFNADRY
     LFAENPVVHL DTATSGSK