ID   EXU_DROVI               Reviewed;         486 AA.
AC   Q24747; B4ME91;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Maternal protein exuperantia;
GN   Name=exu; ORFNames=GJ18765;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8070663; DOI=10.1093/genetics/137.2.521;
RA   Luk S.K.-S., Kilpatrick M., Kerr K., Macdonald P.M.;
RT   "Components acting in localization of bicoid mRNA are conserved among
RT   Drosophila species.";
RL   Genetics 137:521-530(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Ensures the proper localization of the mRNA of the bicoid
CC       gene to the anterior regions of the oocyte thus playing a fundamental
CC       role in the establishment of the polarity of the oocyte. May bind the
CC       bcd mRNA (By similarity). {ECO:0000250}.
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DR   EMBL; L22555; AAA28525.1; -; Genomic_DNA.
DR   EMBL; CH940662; EDW58856.1; -; Genomic_DNA.
DR   PIR; S47891; S47891.
DR   RefSeq; XP_002059444.1; XM_002059408.2.
DR   RefSeq; XP_015024353.1; XM_015168867.1.
DR   AlphaFoldDB; Q24747; -.
DR   SMR; Q24747; -.
DR   STRING; 7244.FBpp0233182; -.
DR   EnsemblMetazoa; FBtr0234690; FBpp0233182; FBgn0013112.
DR   EnsemblMetazoa; FBtr0435475; FBpp0392441; FBgn0013112.
DR   GeneID; 6635821; -.
DR   KEGG; dvi:6635821; -.
DR   eggNOG; ENOG502QVAD; Eukaryota.
DR   HOGENOM; CLU_034404_1_0_1; -.
DR   InParanoid; Q24747; -.
DR   OMA; FLNWLEM; -.
DR   OrthoDB; 744143at2759; -.
DR   PhylomeDB; Q24747; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045450; P:bicoid mRNA localization; IEA:InterPro.
DR   InterPro; IPR037998; Exu.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR040941; SAM_Exu.
DR   PANTHER; PTHR12384; PTHR12384; 1.
DR   Pfam; PF18609; SAM_Exu; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Reference proteome; RNA-binding.
FT   CHAIN           1..486
FT                   /note="Maternal protein exuperantia"
FT                   /id="PRO_0000087146"
FT   REGION          202..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          386..477
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        416..439
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        460..477
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  53957 MW;  FD30313AAE6D309A CRC64;
     MVAVSIDSVI DISAADQSTA ASGVAIKDEL PNGDYILVAV DIDTTGRRLI DEIVQLAAYT
     PTDHFEQYIM PYMNLNPAAR QRHQVRVISI GFFRMLKSMQ TYKIIKSKSE VAALKDFLDW
     LDQLKSKNPN TDGIVLLYHE ERKFIPYMIL QSLVKYGMLD RFTKTVKSFV NSFNLAKSSI
     GDTKHYSLRN LSKILSKAKE DNARVDNDNE ADSNSSSADK HVKNGLQKER DEFDGSASVR
     AKLTFNVALQ LSNLDSTEPE SSEALSNLFN ALKPFTEAIS GDVKELDTQN VHLERQNSFR
     PVFLNYFKTT LYHRVRAVKF RIVLAENGFD LTTLNDIWTE KRIEGLDAAL QGIASLKAED
     KNELVELLDS FFDPAKVTIK PIIKPSTIRR RNKRNTPAHK PGVGSGSRSA SDEFGAGGDK
     SQSVSSVPDS TTKTPSPIKN GGRPQRKRNS RPSLHTKEVK SAESALNNTA PASISLPNYV
     PIAATN