EYA4_CHICK
ID EYA4_CHICK Reviewed; 119 AA.
AC Q9YH98;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=Eyes absent homolog 4;
DE EC=3.1.3.48 {ECO:0000250|UniProtKB:Q99502};
DE Flags: Fragment;
GN Name=EYA4;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Embryo;
RX PubMed=9887327; DOI=10.1093/hmg/8.1.11;
RA Borsani G., DeGrandi A., Ballabio A., Bulfone A., Bernard L., Banfi S.,
RA Gattuso C., Mariani M., Dixon M., Donnai D., Metcalfe K., Winter R.,
RA Robertson M., Axton R., Brown A., van Heyningen V., Hanson I.;
RT "EYA4, a novel vertebrate gene related to Drosophila eyes absent.";
RL Hum. Mol. Genet. 8:11-23(1999).
CC -!- FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-
CC 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone
CC H2AX plays a central role in DNA repair and acts as a mark that
CC distinguishes between apoptotic and repair responses to genotoxic
CC stress. Promotes efficient DNA repair by dephosphorylating H2AX,
CC promoting the recruitment of DNA repair complexes containing MDC1. Its
CC function as histone phosphatase probably explains its role in
CC transcription regulation during organogenesis. May be involved in
CC development of the eye (By similarity). {ECO:0000250|UniProtKB:Q99502}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000250|UniProtKB:Q99502};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:O00167};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250|UniProtKB:O00167};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99502}. Nucleus
CC {ECO:0000250|UniProtKB:Q99502}.
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. EYA family.
CC {ECO:0000305}.
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DR EMBL; AJ008004; CAA07824.1; -; mRNA.
DR RefSeq; NP_001292106.1; NM_001305177.1.
DR AlphaFoldDB; Q9YH98; -.
DR SMR; Q9YH98; -.
DR STRING; 9031.ENSGALP00000022622; -.
DR GeneID; 395716; -.
DR KEGG; gga:395716; -.
DR CTD; 2070; -.
DR VEuPathDB; HostDB:geneid_395716; -.
DR eggNOG; KOG3107; Eukaryota.
DR InParanoid; Q9YH98; -.
DR OrthoDB; 1030296at2759; -.
DR PhylomeDB; Q9YH98; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IBA:GO_Central.
DR GO; GO:0045739; P:positive regulation of DNA repair; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR Gene3D; 3.40.50.12350; -; 1.
DR InterPro; IPR028478; EYA4.
DR InterPro; IPR038102; EYA_dom_sf.
DR InterPro; IPR028472; EYA_fam.
DR PANTHER; PTHR10190; PTHR10190; 1.
DR PANTHER; PTHR10190:SF17; PTHR10190:SF17; 1.
PE 2: Evidence at transcript level;
KW Activator; Chromatin regulator; Cytoplasm; Developmental protein;
KW DNA damage; DNA repair; Hydrolase; Magnesium; Nucleus; Protein phosphatase;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN <1..>119
FT /note="Eyes absent homolog 4"
FT /id="PRO_0000218653"
FT NON_TER 1
FT NON_TER 119
SQ SEQUENCE 119 AA; 13340 MW; 9E6BC4F6F8D0679D CRC64;
RKLAFRYRRV KELYNTYKNN IGGLLGPAKR DAWLQLRAEI EALTDSWLTN ALKSLSIIST
RSNCVNVLVT TTQLIPALAK VLLYSLGGAF PIENIYSATK IGKESCFERI VSRFGTNIT
