EYA4_TAKRU
ID EYA4_TAKRU Reviewed; 119 AA.
AC Q9YHA1;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 80.
DE RecName: Full=Eyes absent homolog 4;
DE EC=3.1.3.48;
DE Flags: Fragment;
GN Name=eya4;
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9887327; DOI=10.1093/hmg/8.1.11;
RA Borsani G., DeGrandi A., Ballabio A., Bulfone A., Bernard L., Banfi S.,
RA Gattuso C., Mariani M., Dixon M., Donnai D., Metcalfe K., Winter R.,
RA Robertson M., Axton R., Brown A., van Heyningen V., Hanson I.;
RT "EYA4, a novel vertebrate gene related to Drosophila eyes absent.";
RL Hum. Mol. Genet. 8:11-23(1999).
CC -!- FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-
CC 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone
CC H2AX plays a central role in DNA repair and acts as a mark that
CC distinguishes between apoptotic and repair responses to genotoxic
CC stress. Promotes efficient DNA repair by dephosphorylating H2AX,
CC promoting the recruitment of DNA repair complexes containing MDC1. Its
CC function as histone phosphatase probably explains its role in
CC transcription regulation during organogenesis. May be involved in
CC development of the eye (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:O00167};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250|UniProtKB:O00167};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. EYA family.
CC {ECO:0000305}.
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DR EMBL; AJ007998; CAA07821.1; -; Genomic_DNA.
DR EMBL; AJ007999; CAA07821.1; JOINED; Genomic_DNA.
DR EMBL; AJ008000; CAA07821.1; JOINED; Genomic_DNA.
DR EMBL; AJ008001; CAA07821.1; JOINED; Genomic_DNA.
DR AlphaFoldDB; Q9YHA1; -.
DR SMR; Q9YHA1; -.
DR STRING; 31033.ENSTRUP00000009464; -.
DR eggNOG; KOG3107; Eukaryota.
DR InParanoid; Q9YHA1; -.
DR Proteomes; UP000005226; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR Gene3D; 3.40.50.12350; -; 1.
DR InterPro; IPR028478; EYA4.
DR InterPro; IPR038102; EYA_dom_sf.
DR InterPro; IPR028472; EYA_fam.
DR PANTHER; PTHR10190; PTHR10190; 1.
DR PANTHER; PTHR10190:SF17; PTHR10190:SF17; 1.
PE 3: Inferred from homology;
KW Activator; Chromatin regulator; Cytoplasm; Developmental protein;
KW DNA damage; DNA repair; Hydrolase; Magnesium; Nucleus; Protein phosphatase;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN <1..>119
FT /note="Eyes absent homolog 4"
FT /id="PRO_0000218654"
FT NON_TER 1
FT NON_TER 119
SQ SEQUENCE 119 AA; 13350 MW; 9BB3E01C3372C904 CRC64;
RKLAFRYRRV KELYTTYKNN VGGLLGPAKR DAWLQLRAEV EALTDSWLTH ALKSLSIISS
RSNCVNVLVT TTQLIPALAK VLLYSLGAVF PIENIYSATK IGKESCFERI VSRFGTNIT
