EYS_HUMAN
ID EYS_HUMAN Reviewed; 3165 AA.
AC Q5T1H1; A2RUR2; A8MVE7; B7TYK8; B7UUQ3; B7ZBE7; B7ZBE8; B7ZBR3; B9ZVD2;
AC Q5SZM4; Q5T3C8; Q5T669; Q5TEL3; Q5TEL4; Q5VVG4; Q6UY05; Q9H557; Q9NQ15;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 5.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein eyes shut homolog;
DE AltName: Full=Epidermal growth factor-like protein 10;
DE Short=EGF-like protein 10;
DE AltName: Full=Epidermal growth factor-like protein 11;
DE Short=EGF-like protein 11;
DE AltName: Full=Protein spacemaker homolog;
DE Flags: Precursor;
GN Name=EYS; Synonyms=C6orf178, C6orf179, C6orf180, EGFL10, EGFL11, SPAM;
GN ORFNames=UNQ9424/PRO34591;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), TISSUE SPECIFICITY, AND INVOLVEMENT
RP IN RP25.
RX PubMed=18976725; DOI=10.1016/j.ajhg.2008.10.014;
RA Collin R.W.J., Littink K.W., Klevering B.J., van den Born L.I.,
RA Koenekoop R.K., Zonneveld M.N., Blokland E.A.W., Strom T.M., Hoyng C.B.,
RA den Hollander A.I., Cremers F.P.M.;
RT "Identification of a 2 Mb human ortholog of Drosophila eyes shut/spacemaker
RT that is mutated in patients with retinitis pigmentosa.";
RL Am. J. Hum. Genet. 83:594-603(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION,
RP TISSUE SPECIFICITY, AND INVOLVEMENT IN RP25.
RX PubMed=18836446; DOI=10.1038/ng.241;
RA Abd El-Aziz M.M., Barragan I., O'Driscoll C.A., Goodstadt L., Prigmore E.,
RA Borrego S., Mena M., Pieras J.I., El-Ashry M.F., Safieh L.A., Shah A.,
RA Cheetham M.E., Carter N.P., Chakarova C., Ponting C.P., Bhattacharya S.S.,
RA Antinolo G.;
RT "EYS, encoding an ortholog of Drosophila spacemaker, is mutated in
RT autosomal recessive retinitis pigmentosa.";
RL Nat. Genet. 40:1285-1287(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT MET-120.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP INVOLVEMENT IN RP25.
RX PubMed=20696082; DOI=10.1186/1471-2350-11-121;
RA Huang Y., Zhang J., Li C., Yang G., Liu M., Wang Q.K., Tang Z.;
RT "Identification of a novel homozygous nonsense mutation in EYS in a Chinese
RT family with autosomal recessive retinitis pigmentosa.";
RL BMC Med. Genet. 11:121-121(2010).
RN [7]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=27737822; DOI=10.1242/bio.021584;
RA Yu M., Liu Y., Li J., Natale B.N., Cao S., Wang D., Amack J.D., Hu H.;
RT "Eyes shut homolog is required for maintaining the ciliary pocket and
RT survival of photoreceptors in zebrafish.";
RL Biol. Open 5:1662-1673(2016).
RN [8]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY (ISOFORMS 1; 2; 3 AND 4).
RX PubMed=27846257; DOI=10.1371/journal.pone.0166397;
RA Alfano G., Kruczek P.M., Shah A.Z., Kramarz B., Jeffery G., Zelhof A.C.,
RA Bhattacharya S.S.;
RT "EYS is a protein associated with the ciliary axoneme in rods and cones.";
RL PLoS ONE 11:E0166397-E0166397(2016).
RN [9]
RP VARIANTS RP25 SER-745; ARG-1484; VAL-2017; LEU-2211; LYS-2503 AND GLU-2945,
RP AND VARIANTS PRO-1987; ASP-2040 AND CYS-2556.
RX PubMed=21069908; DOI=10.1002/humu.21334;
RA Barragan I., Borrego S., Pieras J.I., Gonzalez-del Pozo M., Santoyo J.,
RA Ayuso C., Baiget M., Millan J.M., Mena M., El-Aziz M.M., Audo I., Zeitz C.,
RA Littink K.W., Dopazo J., Bhattacharya S.S., Antinolo G.;
RT "Mutation spectrum of EYS in Spanish patients with autosomal recessive
RT retinitis pigmentosa.";
RL Hum. Mutat. 31:E1772-E1800(2010).
RN [10]
RP VARIANTS RP25 SER-618; SER-745; SER-1110; ARG-1176; PHE-1232; TYR-1682;
RP GLY-1747; MET-1869; TYR-2139; PRO-2189; LEU-2211; THR-2829; TYR-2911 AND
RP GLU-2928, AND VARIANTS GLN-94; ILE-112; MET-120; LEU-135; PHE-136; ASN-326;
RP ASN-532; LEU-551; ARG-571; SER-631; VAL-641; ILE-834; ARG-938; LYS-1163;
RP VAL-1263; GLU-1325; VAL-1361; GLU-1365; SER-1419; THR-1451; TRP-1515;
RP GLY-1517; VAL-1662; ILE-1664; LEU-1739; PHE-1748; SER-1837; VAL-1873;
RP ILE-1902; GLY-1915; PRO-1987; ALA-1993; VAL-1999; ASP-2040; SER-2151;
RP GLN-2326; CYS-2556; ARG-2599; PRO-2757 AND ILE-2831.
RX PubMed=20333770; DOI=10.1002/humu.21249;
RA Audo I., Sahel J.-A., Mohand-Saied S., Lancelot M.-E., Antonio A.,
RA Moskova-Doumanova V., Nandrot E.F., Doumanov J., Barragan I., Antinolo G.,
RA Bhattacharya S.S., Zeitz C.;
RT "EYS is a major gene for rod-cone dystrophies in France.";
RL Hum. Mutat. 31:E1406-E1435(2010).
RN [11]
RP VARIANT ASP-2040.
RX PubMed=26593283; DOI=10.1002/humu.22934;
RA Zaki M.S., Heller R., Thoenes M., Nuernberg G., Stern-Schneider G.,
RA Nuernberg P., Karnati S., Swan D., Fateen E., Nagel-Wolfrum K.,
RA Mostafa M.I., Thiele H., Wolfrum U., Baumgart-Vogt E., Bolz H.J.;
RT "PEX6 is expressed in photoreceptor cilia and mutated in deafblindness with
RT enamel dysplasia and microcephaly.";
RL Hum. Mutat. 37:170-174(2016).
CC -!- FUNCTION: Required to maintain the integrity of photoreceptor cells
CC (PubMed:18836446). Specifically required for normal morphology of the
CC photoreceptor ciliary pocket, and might thus facilitate protein
CC trafficking between the photoreceptor inner and outer segments via the
CC transition zone (By similarity). {ECO:0000250|UniProtKB:B8JI71,
CC ECO:0000269|PubMed:18836446}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer
CC segment {ECO:0000269|PubMed:27737822}. Cell projection, cilium
CC {ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:27846257}. Cytoplasm,
CC cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27846257}. Cytoplasm,
CC cytoskeleton, microtubule organizing center, centrosome
CC {ECO:0000269|PubMed:27846257}. Secreted, extracellular space,
CC extracellular matrix, interphotoreceptor matrix
CC {ECO:0000269|PubMed:27737822}. Note=Localizes to discrete puncta at, or
CC adjacent to, the photoreceptor connecting cilium (PubMed:27737822).
CC Highly expressed in cone photoreceptor outer segments
CC (PubMed:27737822). Weakly expressed in rod photoreceptor outer segments
CC (By similarity). May localize to the cilium axoneme (PubMed:27846257).
CC May also be secreted into the interphotoreceptor extracellular matrix
CC (PubMed:27737822). {ECO:0000250|UniProtKB:A0A2K5V015,
CC ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:27846257}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=4 {ECO:0000303|PubMed:27846257};
CC IsoId=Q5T1H1-3; Sequence=Displayed;
CC Name=1;
CC IsoId=Q5T1H1-1; Sequence=VSP_036709;
CC Name=3 {ECO:0000303|PubMed:27846257};
CC IsoId=Q5T1H1-2; Sequence=VSP_035821, VSP_035822;
CC Name=2 {ECO:0000303|PubMed:27846257};
CC IsoId=Q5T1H1-4; Sequence=VSP_047161, VSP_035822;
CC -!- TISSUE SPECIFICITY: Expressed in retina (at protein level)
CC (PubMed:18976725, PubMed:18836446, PubMed:27737822, PubMed:27846257).
CC Isoform 1: Detected in retina (PubMed:27846257). Isoform 2: Detected in
CC retina (PubMed:27846257). Isoform 3: Strongly expressed in retina and
CC testis (PubMed:27846257). Isoform 4: Strongly expressed in testis, and
CC weakly expressed in retina (PubMed:27846257).
CC {ECO:0000269|PubMed:18836446, ECO:0000269|PubMed:18976725,
CC ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:27846257}.
CC -!- DISEASE: Retinitis pigmentosa 25 (RP25) [MIM:602772]: A retinal
CC dystrophy belonging to the group of pigmentary retinopathies. Retinitis
CC pigmentosa is characterized by retinal pigment deposits visible on
CC fundus examination and primary loss of rod photoreceptor cells followed
CC by secondary loss of cone photoreceptors. Patients typically have night
CC vision blindness and loss of midperipheral visual field. As their
CC condition progresses, they lose their far peripheral visual field and
CC eventually central vision as well. {ECO:0000269|PubMed:18836446,
CC ECO:0000269|PubMed:18976725, ECO:0000269|PubMed:20333770,
CC ECO:0000269|PubMed:20696082, ECO:0000269|PubMed:21069908}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- MISCELLANEOUS: Although the protein is conserved in Drosophila, the
CC gene encoding the orthologous protein is inactive in rodents.
CC -!- SIMILARITY: Belongs to the EYS family. {ECO:0000305}.
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DR EMBL; FM209056; CAR64275.1; -; mRNA.
DR EMBL; FJ416331; ACJ37365.1; -; mRNA.
DR EMBL; AY358133; AAQ88500.1; -; mRNA.
DR EMBL; AL050329; CAB99359.1; -; Genomic_DNA.
DR EMBL; AL078597; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL109612; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL109922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL132767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL133322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL137007; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353669; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL354913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL355357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL356454; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL357375; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL450319; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL450324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL450394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL589916; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590546; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL590784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL603767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC133011; AAI33012.1; -; mRNA.
DR EMBL; BC133013; AAI33014.1; -; mRNA.
DR CCDS; CCDS47445.1; -. [Q5T1H1-1]
DR CCDS; CCDS47446.1; -. [Q5T1H1-4]
DR CCDS; CCDS4967.1; -. [Q5T1H1-2]
DR CCDS; CCDS78156.1; -. [Q5T1H1-3]
DR RefSeq; NP_001136272.1; NM_001142800.1. [Q5T1H1-1]
DR RefSeq; NP_001136273.1; NM_001142801.1. [Q5T1H1-4]
DR RefSeq; NP_001278938.1; NM_001292009.1. [Q5T1H1-3]
DR RefSeq; NP_938024.1; NM_198283.1. [Q5T1H1-2]
DR BioGRID; 131371; 1.
DR IntAct; Q5T1H1; 1.
DR STRING; 9606.ENSP00000424243; -.
DR GlyGen; Q5T1H1; 8 sites.
DR iPTMnet; Q5T1H1; -.
DR PhosphoSitePlus; Q5T1H1; -.
DR BioMuta; EYS; -.
DR DMDM; 338817908; -.
DR MassIVE; Q5T1H1; -.
DR PaxDb; Q5T1H1; -.
DR PeptideAtlas; Q5T1H1; -.
DR PRIDE; Q5T1H1; -.
DR ProteomicsDB; 64092; -.
DR ProteomicsDB; 64263; -. [Q5T1H1-3]
DR ProteomicsDB; 64264; -. [Q5T1H1-1]
DR ProteomicsDB; 64265; -. [Q5T1H1-2]
DR Antibodypedia; 31174; 28 antibodies from 9 providers.
DR DNASU; 346007; -.
DR Ensembl; ENST00000342421.9; ENSP00000341818.5; ENSG00000188107.15. [Q5T1H1-2]
DR Ensembl; ENST00000370621.7; ENSP00000359655.3; ENSG00000188107.15. [Q5T1H1-3]
DR Ensembl; ENST00000393380.6; ENSP00000377042.2; ENSG00000188107.15. [Q5T1H1-4]
DR Ensembl; ENST00000503581.6; ENSP00000424243.1; ENSG00000188107.15. [Q5T1H1-1]
DR GeneID; 346007; -.
DR KEGG; hsa:346007; -.
DR MANE-Select; ENST00000503581.6; ENSP00000424243.1; NM_001142800.2; NP_001136272.1. [Q5T1H1-1]
DR UCSC; uc003peq.4; human. [Q5T1H1-3]
DR CTD; 346007; -.
DR DisGeNET; 346007; -.
DR GeneCards; EYS; -.
DR GeneReviews; EYS; -.
DR HGNC; HGNC:21555; EYS.
DR HPA; ENSG00000188107; Tissue enriched (retina).
DR MalaCards; EYS; -.
DR MIM; 602772; phenotype.
DR MIM; 612424; gene.
DR neXtProt; NX_Q5T1H1; -.
DR OpenTargets; ENSG00000188107; -.
DR Orphanet; 791; Retinitis pigmentosa.
DR PharmGKB; PA164719488; -.
DR VEuPathDB; HostDB:ENSG00000188107; -.
DR eggNOG; KOG1217; Eukaryota.
DR eggNOG; KOG3509; Eukaryota.
DR GeneTree; ENSGT00940000163729; -.
DR HOGENOM; CLU_000393_0_0_1; -.
DR InParanoid; Q5T1H1; -.
DR OMA; YHCSCMP; -.
DR OrthoDB; 115967at2759; -.
DR PhylomeDB; Q5T1H1; -.
DR TreeFam; TF317565; -.
DR PathwayCommons; Q5T1H1; -.
DR SignaLink; Q5T1H1; -.
DR BioGRID-ORCS; 346007; 18 hits in 1065 CRISPR screens.
DR ChiTaRS; EYS; human.
DR GenomeRNAi; 346007; -.
DR Pharos; Q5T1H1; Tbio.
DR PRO; PR:Q5T1H1; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5T1H1; protein.
DR Bgee; ENSG00000188107; Expressed in islet of Langerhans and 100 other tissues.
DR ExpressionAtlas; Q5T1H1; baseline and differential.
DR Genevisible; Q5T1H1; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050908; P:detection of light stimulus involved in visual perception; IMP:UniProtKB.
DR GO; GO:0043403; P:skeletal muscle tissue regeneration; IMP:UniProtKB.
DR CDD; cd00110; LamG; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR Pfam; PF00008; EGF; 10.
DR Pfam; PF12661; hEGF; 4.
DR Pfam; PF02210; Laminin_G_2; 5.
DR SMART; SM00181; EGF; 28.
DR SMART; SM00179; EGF_CA; 20.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; SSF49899; 5.
DR SUPFAM; SSF57184; SSF57184; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 7.
DR PROSITE; PS00022; EGF_1; 23.
DR PROSITE; PS01186; EGF_2; 15.
DR PROSITE; PS50026; EGF_3; 27.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
PE 1: Evidence at protein level;
KW Alternative splicing; Calcium; Cell projection; Cytoplasm; Cytoskeleton;
KW Disease variant; Disulfide bond; EGF-like domain; Extracellular matrix;
KW Glycoprotein; Reference proteome; Repeat; Retinitis pigmentosa; Secreted;
KW Sensory transduction; Signal; Vision.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..3165
FT /note="Protein eyes shut homolog"
FT /id="PRO_0000337014"
FT DOMAIN 170..212
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 213..254
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 256..292
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 332..368
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 370..406
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 567..602
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 643..679
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 681..720
FT /note="EGF-like 8; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 733..769
FT /note="EGF-like 9; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 771..807
FT /note="EGF-like 10; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 809..847
FT /note="EGF-like 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 849..888
FT /note="EGF-like 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 890..926
FT /note="EGF-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 928..964
FT /note="EGF-like 14; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 966..1002
FT /note="EGF-like 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1004..1040
FT /note="EGF-like 16; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1042..1077
FT /note="EGF-like 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1079..1115
FT /note="EGF-like 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1117..1159
FT /note="EGF-like 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1161..1197
FT /note="EGF-like 20; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1883..2063
FT /note="Laminin G-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 2099..2140
FT /note="EGF-like 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2145..2339
FT /note="Laminin G-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 2335..2368
FT /note="EGF-like 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2371..2408
FT /note="EGF-like 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2419..2609
FT /note="Laminin G-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 2610..2646
FT /note="EGF-like 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2648..2689
FT /note="EGF-like 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2717..2895
FT /note="Laminin G-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 2896..2932
FT /note="EGF-like 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2933..2970
FT /note="EGF-like 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2975..3165
FT /note="Laminin G-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 269
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 272
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 311
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 506
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 566
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 174..189
FT /evidence="ECO:0000250"
FT DISULFID 183..200
FT /evidence="ECO:0000250"
FT DISULFID 202..211
FT /evidence="ECO:0000250"
FT DISULFID 217..228
FT /evidence="ECO:0000250"
FT DISULFID 222..242
FT /evidence="ECO:0000250"
FT DISULFID 244..253
FT /evidence="ECO:0000250"
FT DISULFID 260..270
FT /evidence="ECO:0000250"
FT DISULFID 265..280
FT /evidence="ECO:0000250"
FT DISULFID 282..291
FT /evidence="ECO:0000250"
FT DISULFID 341..356
FT /evidence="ECO:0000250"
FT DISULFID 358..367
FT /evidence="ECO:0000250"
FT DISULFID 374..385
FT /evidence="ECO:0000250"
FT DISULFID 396..405
FT /evidence="ECO:0000250"
FT DISULFID 575..590
FT /evidence="ECO:0000250"
FT DISULFID 592..601
FT /evidence="ECO:0000250"
FT DISULFID 669..678
FT /evidence="ECO:0000250"
FT DISULFID 685..696
FT /evidence="ECO:0000250"
FT DISULFID 690..705
FT /evidence="ECO:0000250"
FT DISULFID 707..719
FT /evidence="ECO:0000250"
FT DISULFID 737..748
FT /evidence="ECO:0000250"
FT DISULFID 742..757
FT /evidence="ECO:0000250"
FT DISULFID 759..768
FT /evidence="ECO:0000250"
FT DISULFID 775..786
FT /evidence="ECO:0000250"
FT DISULFID 780..795
FT /evidence="ECO:0000250"
FT DISULFID 797..806
FT /evidence="ECO:0000250"
FT DISULFID 813..824
FT /evidence="ECO:0000250"
FT DISULFID 818..835
FT /evidence="ECO:0000250"
FT DISULFID 837..846
FT /evidence="ECO:0000250"
FT DISULFID 853..866
FT /evidence="ECO:0000250"
FT DISULFID 860..876
FT /evidence="ECO:0000250"
FT DISULFID 878..887
FT /evidence="ECO:0000250"
FT DISULFID 894..905
FT /evidence="ECO:0000250"
FT DISULFID 899..914
FT /evidence="ECO:0000250"
FT DISULFID 916..925
FT /evidence="ECO:0000250"
FT DISULFID 932..943
FT /evidence="ECO:0000250"
FT DISULFID 937..952
FT /evidence="ECO:0000250"
FT DISULFID 954..963
FT /evidence="ECO:0000250"
FT DISULFID 970..981
FT /evidence="ECO:0000250"
FT DISULFID 975..990
FT /evidence="ECO:0000250"
FT DISULFID 992..1001
FT /evidence="ECO:0000250"
FT DISULFID 1008..1019
FT /evidence="ECO:0000250"
FT DISULFID 1013..1028
FT /evidence="ECO:0000250"
FT DISULFID 1030..1039
FT /evidence="ECO:0000250"
FT DISULFID 1046..1056
FT /evidence="ECO:0000250"
FT DISULFID 1051..1065
FT /evidence="ECO:0000250"
FT DISULFID 1067..1076
FT /evidence="ECO:0000250"
FT DISULFID 1083..1094
FT /evidence="ECO:0000250"
FT DISULFID 1088..1103
FT /evidence="ECO:0000250"
FT DISULFID 1105..1114
FT /evidence="ECO:0000250"
FT DISULFID 1121..1137
FT /evidence="ECO:0000250"
FT DISULFID 1131..1147
FT /evidence="ECO:0000250"
FT DISULFID 1149..1158
FT /evidence="ECO:0000250"
FT DISULFID 1165..1176
FT /evidence="ECO:0000250"
FT DISULFID 1170..1185
FT /evidence="ECO:0000250"
FT DISULFID 1187..1196
FT /evidence="ECO:0000250"
FT DISULFID 2037..2063
FT /evidence="ECO:0000250"
FT DISULFID 2103..2114
FT /evidence="ECO:0000250"
FT DISULFID 2108..2128
FT /evidence="ECO:0000250"
FT DISULFID 2130..2139
FT /evidence="ECO:0000250"
FT DISULFID 2339..2350
FT /evidence="ECO:0000250"
FT DISULFID 2344..2359
FT /evidence="ECO:0000250"
FT DISULFID 2375..2386
FT /evidence="ECO:0000250"
FT DISULFID 2380..2396
FT /evidence="ECO:0000250"
FT DISULFID 2398..2407
FT /evidence="ECO:0000250"
FT DISULFID 2576..2609
FT /evidence="ECO:0000250"
FT DISULFID 2614..2625
FT /evidence="ECO:0000250"
FT DISULFID 2619..2634
FT /evidence="ECO:0000250"
FT DISULFID 2636..2645
FT /evidence="ECO:0000250"
FT DISULFID 2652..2668
FT /evidence="ECO:0000250"
FT DISULFID 2662..2677
FT /evidence="ECO:0000250"
FT DISULFID 2679..2688
FT /evidence="ECO:0000250"
FT DISULFID 2868..2895
FT /evidence="ECO:0000250"
FT DISULFID 2900..2911
FT /evidence="ECO:0000250"
FT DISULFID 2905..2920
FT /evidence="ECO:0000250"
FT DISULFID 2922..2931
FT /evidence="ECO:0000250"
FT DISULFID 2937..2948
FT /evidence="ECO:0000250"
FT DISULFID 2942..2958
FT /evidence="ECO:0000250"
FT DISULFID 2960..2969
FT /evidence="ECO:0000250"
FT VAR_SEQ 590..594
FT /note="CSCSL -> RILNTVIPHQIQQHIERFIQHDQVGFIVRI (in isoform
FT 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_047161"
FT VAR_SEQ 590..594
FT /note="CSCSL -> YLCII (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_035821"
FT VAR_SEQ 595..3165
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_035822"
FT VAR_SEQ 2691..2711
FT /note="Missing (in isoform 1)"
FT /evidence="ECO:0000303|PubMed:18836446"
FT /id="VSP_036709"
FT VARIANT 94
FT /note="P -> Q (in dbSNP:rs111947397)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063437"
FT VARIANT 112
FT /note="V -> I (in dbSNP:rs112609906)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063438"
FT VARIANT 120
FT /note="T -> M (in dbSNP:rs12193967)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:20333770"
FT /id="VAR_035301"
FT VARIANT 135
FT /note="T -> L (requires 2 nucleotide substitutions)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063439"
FT VARIANT 136
FT /note="V -> F (in dbSNP:rs543011021)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063440"
FT VARIANT 326
FT /note="S -> N (in dbSNP:rs112822256)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063441"
FT VARIANT 532
FT /note="K -> N (in dbSNP:rs61753611)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063442"
FT VARIANT 551
FT /note="R -> L"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063443"
FT VARIANT 571
FT /note="Q -> R (in dbSNP:rs61753610)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063444"
FT VARIANT 618
FT /note="G -> S (in RP25; dbSNP:rs142450703)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063445"
FT VARIANT 631
FT /note="G -> S (in dbSNP:rs9342464)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063446"
FT VARIANT 641
FT /note="E -> V (in dbSNP:rs17411795)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063447"
FT VARIANT 745
FT /note="N -> S (in RP25; unknown pathological significance;
FT dbSNP:rs201652272)"
FT /evidence="ECO:0000269|PubMed:20333770,
FT ECO:0000269|PubMed:21069908"
FT /id="VAR_063448"
FT VARIANT 834
FT /note="V -> I (in dbSNP:rs112464110)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063449"
FT VARIANT 852
FT /note="L -> P (in dbSNP:rs9294631)"
FT /id="VAR_043561"
FT VARIANT 938
FT /note="K -> R (in dbSNP:rs367857088)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063450"
FT VARIANT 1110
FT /note="T -> S (in RP25; dbSNP:rs143327210)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063451"
FT VARIANT 1163
FT /note="N -> K (in dbSNP:rs150951106)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063452"
FT VARIANT 1176
FT /note="C -> R (in RP25)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063453"
FT VARIANT 1232
FT /note="I -> F (in RP25; dbSNP:rs190009374)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063454"
FT VARIANT 1263
FT /note="I -> V (in dbSNP:rs17404123)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063455"
FT VARIANT 1325
FT /note="Q -> E (in dbSNP:rs12663622)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063456"
FT VARIANT 1361
FT /note="I -> V (in dbSNP:rs17403955)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063457"
FT VARIANT 1365
FT /note="K -> E (in dbSNP:rs16895519)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063458"
FT VARIANT 1419
FT /note="L -> S (in dbSNP:rs624851)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063459"
FT VARIANT 1451
FT /note="I -> T (in dbSNP:rs62415828)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063460"
FT VARIANT 1484
FT /note="W -> R (in RP25; dbSNP:rs1260400598)"
FT /evidence="ECO:0000269|PubMed:21069908"
FT /id="VAR_064417"
FT VARIANT 1515
FT /note="R -> W (in dbSNP:rs62415827)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063461"
FT VARIANT 1517
FT /note="S -> G (in dbSNP:rs62415826)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063462"
FT VARIANT 1662
FT /note="D -> V (in dbSNP:rs147641443)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063463"
FT VARIANT 1664
FT /note="T -> I (in dbSNP:rs561830314)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063464"
FT VARIANT 1682
FT /note="D -> Y (in RP25; dbSNP:rs75831552)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063465"
FT VARIANT 1739
FT /note="P -> L"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063466"
FT VARIANT 1747
FT /note="E -> G (in RP25; dbSNP:rs535663619)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063467"
FT VARIANT 1748
FT /note="L -> F (in dbSNP:rs57312007)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063468"
FT VARIANT 1837
FT /note="W -> S (in dbSNP:rs199689193)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063469"
FT VARIANT 1869
FT /note="L -> M (in RP25)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063470"
FT VARIANT 1873
FT /note="L -> V (in dbSNP:rs16895517)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063471"
FT VARIANT 1902
FT /note="N -> I (in dbSNP:rs9353806)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063472"
FT VARIANT 1915
FT /note="S -> G (in dbSNP:rs188093810)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063473"
FT VARIANT 1987
FT /note="T -> P (in dbSNP:rs1278246029)"
FT /evidence="ECO:0000269|PubMed:20333770,
FT ECO:0000269|PubMed:21069908"
FT /id="VAR_063474"
FT VARIANT 1993
FT /note="T -> A (in dbSNP:rs115066356)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063475"
FT VARIANT 1999
FT /note="I -> V (in dbSNP:rs893294562)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063476"
FT VARIANT 2017
FT /note="G -> V (in RP25; dbSNP:rs868349465)"
FT /evidence="ECO:0000269|PubMed:21069908"
FT /id="VAR_064418"
FT VARIANT 2040
FT /note="V -> D (in dbSNP:rs201580493)"
FT /evidence="ECO:0000269|PubMed:20333770,
FT ECO:0000269|PubMed:21069908, ECO:0000269|PubMed:26593283"
FT /id="VAR_063477"
FT VARIANT 2139
FT /note="C -> Y (in RP25; dbSNP:rs749909863)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063478"
FT VARIANT 2151
FT /note="N -> S (in dbSNP:rs141603172)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063479"
FT VARIANT 2189
FT /note="L -> P (in RP25)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063480"
FT VARIANT 2211
FT /note="S -> L (in RP25; unknown pathological significance;
FT dbSNP:rs145623359)"
FT /evidence="ECO:0000269|PubMed:20333770,
FT ECO:0000269|PubMed:21069908"
FT /id="VAR_063481"
FT VARIANT 2326
FT /note="R -> Q (in dbSNP:rs4710457)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063482"
FT VARIANT 2503
FT /note="E -> K (in RP25; dbSNP:rs768964978)"
FT /evidence="ECO:0000269|PubMed:21069908"
FT /id="VAR_064419"
FT VARIANT 2556
FT /note="S -> C (in dbSNP:rs66462731)"
FT /evidence="ECO:0000269|PubMed:20333770,
FT ECO:0000269|PubMed:21069908"
FT /id="VAR_063483"
FT VARIANT 2599
FT /note="H -> R (in dbSNP:rs74636274)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063484"
FT VARIANT 2757
FT /note="A -> P (in dbSNP:rs1250317776)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063485"
FT VARIANT 2829
FT /note="A -> T (in RP25; dbSNP:rs111991705)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063486"
FT VARIANT 2831
FT /note="T -> I (in dbSNP:rs144513453)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063487"
FT VARIANT 2911
FT /note="C -> Y (in RP25)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063488"
FT VARIANT 2928
FT /note="G -> E (in RP25)"
FT /evidence="ECO:0000269|PubMed:20333770"
FT /id="VAR_063489"
FT VARIANT 2945
FT /note="Q -> E (in RP25)"
FT /evidence="ECO:0000269|PubMed:21069908"
FT /id="VAR_064420"
FT CONFLICT 652
FT /note="C -> R (in Ref. 1; CAR64275)"
FT /evidence="ECO:0000305"
FT CONFLICT 1056
FT /note="C -> Y (in Ref. 1; CAR64275)"
FT /evidence="ECO:0000305"
FT CONFLICT 1183
FT /note="Y -> H (in Ref. 1; CAR64275)"
FT /evidence="ECO:0000305"
FT CONFLICT 1922
FT /note="Y -> H (in Ref. 1; CAR64275)"
FT /evidence="ECO:0000305"
FT CONFLICT 2441
FT /note="H -> R (in Ref. 1; CAR64275)"
FT /evidence="ECO:0000305"
FT CONFLICT 2466
FT /note="G -> E (in Ref. 1; CAR64275)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 3165 AA; 350796 MW; 71119473EA872B00 CRC64;
MTDKSIVILS LMVFHSSFIN GKTCRRQLVE EWHPQPSSYV VNWTLTENIC LDFYRDCWFL
GVNTKIDTSG NQAVPQICPL QIQLGDILVI SSEPSLQFPE INLMNVSETS FVGCVQNTTT
EDQLLFGCRL KGMHTVNSKW LSVGTHYFIT VMASGPSPCP LGLRLNVTVK QQFCQESLSS
EFCSGHGKCL SEAWSKTYSC HCQPPFSGKY CQELDACSFK PCKNNGSCIN KRENWDEQAY
ECVCHPPFTG KNCSEIIGQC QPHVCFHGNC SNITSNSFIC ECDEQFSGPF CEVSAKPCVS
LLFWKRGICP NSSSAYTYEC PKGSSSQNGE TDVSEFSLVP CQNGTDCIKI SNDVMCICSP
IFTDLLCKSI QTSCESFPLR NNATCKKCEK DYPCSCISGF TEKNCEKAID HCKLLSINCL
NEEWCFNIIG RFKYVCIPGC TKNPCWFLKN VYLIHQHLCY CGVTFHGICQ DKGPAQFEYV
WQLGFAGSEG EKCQGVIDAY FFLAANCTED ATYVNDPEDN NSSCWFPHEG TKEICANGCS
CLSEEDSQEY RYLCFLRWAG NMYLENTTDD QENECQHEAV CKDEINRPRC SCSLSYIGRL
CVVNVDYCLG NHSISVHGLC LALSHNCNCS GLQRYERNIC EIDTEDCKSA SCKNGTTSTH
LRGYFFRKCV PGFKGTQCEI DIDECASHPC KNGATCIDQP GNYFCQCVPP FKVVDGFSCL
CNPGYVGIRC EQDIDDCILN ACEHNSTCKD LHLSYQCVCL SDWEGNFCEQ ESNECKMNPC
KNNSTCTDLY KSYRCECTSG WTGQNCSEEI NECDSDPCMN GGLCHESTIP GQFVCLCPPL
YTGQFCHQRY NLCDLLHNPC RNNSTCLALV DANQHCICRE EFEGKNCEID VKDCLFLSCQ
DYGDCEDMVN NFRCICRPGF SGSLCEIEIN ECSSEPCKNN GTCVDLTNRF FCNCEPEYHG
PFCELDVNKC KISPCLDEEN CVYRTDGYNC LCAPGYTGIN CEINLDECLS EPCLHDGVCI
DGINHYTCDC KSGFFGTHCE TNANDCLSNP CLHGRCTELI NEYPCSCDAD GTSTQCKIKI
NDCTSIPCMN EGFCQKSAHG FTCICPRGYT GAYCEKSIDN CAEPELNSVI CLNGGICVDG
PGHTFDCRCL PGFSGQFCEI NINECSSSPC LHGADCEDHI NGYVCKCQPG WSGHHCENEL
ECIPNSCVHE LCMENEPGST CLCTPGFMTC SIGLLCGDEI RRITCLTPIF QRTDPISTQT
YTIPPSETLV SSFPSIKATR IPAIMDTYPV DQGPKQTGIV KHDILPTTGL ATLRISTPLE
SYLLQELIVT RELSAKHSLL SSADVSSSRF LNFGIRDPAQ IVQDKTSVSH MPIRTSAATL
GFFFPDRRAR TPFIMSSLMS DFIFPTQSLL FENCQTVALS ATPTTSVIRS IPGADIELNR
QSLLSRGFLL IAASISATPV VSRGAQEDIE EYSADSLISR REHWRLLSPS MSPIFPAKVI
ISKQVTILNS SALHRFSTKA FNPSEYQAIT EASSNQRLTN IKSQAADSLR ELSQTCATCS
MTEIKSSREF SDQVLHSKQS HFYETFWMNS AILASWYALM GAQTITSGHS FSSATEITPS
VAFTEVPSLF PSKKSAKRTI LSSSLEESIT LSSNLDVNLC LDKTCLSIVP SQTISSDLMN
SDLTSKMTTD ELSVSENILK LLKIRQYGIT MGPTEVLNQE SLLDMEKSKG SHTLFKLHPS
DSSLDFELNL QIYPDVTLKT YSEITHANDF KNNLPPLTGS VPDFSEVTTN VAFYTVSATP
ALSIQTSSSM SVIRPDWPYF TDYMTSLKKE VKTSSEWSKW ELQPSVQYQE FPTASRHLPF
TRSLTLSSLE SILAPQRLMI SDFSCVRYYG DSYLEFQNVA LNPQNNISLE FQTFSSYGLL
LYVKQDSNLV DGFFIQLFIE NGTLKYHFYC PGEAKFKSIN TTVRVDNGQK YTLLIRQELD
PCNAELTILG RNTQICESIN HVLGKPLPKS GSVFIGGFPD LHGKIQMPVP VKNFTGCIEV
IEINNWRSFI PSKAVKNYHI NNCRSQGFML SPTASFVDAS DVTQGVDTMW TSVSPSVAAP
SVCQQDVCHN GGTCHAIFLS SGIVSFQCDC PLHFTGRFCE KDAGLFFPSF NGNSYLELPF
LKFVLEKEHN RTVTIYLTIK TNSLNGTILY SNGNNCGKQF LHLFLVEGRP SVKYGCGNSQ
NILTVSANYS INTNAFTPIT IRYTTPVGSP GVVCMIEMTA DGKPPVQKKD TEISHASQAY
FESMFLGHIP ANVQIHKKAG PVYGFRGCIL DLQVNNKEFF IIDEARHGKN IENCHVPWCA
HHLCRNNGTC ISDNENLFCE CPRLYSGKLC QFASCENNPC GNGATCVPKS GTDIVCLCPY
GRSGPLCTDA INITQPRFSG TDAFGYTSFL AYSRISDISF HYEFHLKFQL ANNHSALQNN
LIFFTGQKGH GLNGDDFLAV GLLNGSVVYS YNLGSGIASI RSEPLNLSLG VHTVHLGKFF
QEGWLKVDDH KNKSIIAPGR LVGLNVFSQF YVGGYSEYTP DLLPNGADFK NGFQGCIFTL
QVRTEKDGHF RGLGNPEGHP NAGRSVGQCH ASPCSLMKCG NGGTCIESGT SVYCNCTTGW
KGSFCTETVS TCDPEHDPPH HCSRGATCIS LPHGYTCFCP LGTTGIYCEQ ALILIVILEK
PKPAERKVKK EALSISDPSF RSNELSWMSF ASFHVRKKTH IQLQFQPLAA DGILFYAAQH
LKAQSGDFLC ISLVNSSVQL RYNLGDRTII LETLQKVTIN GSTWHIIKAG RVGAEGYLDL
DGINVTEKAS TKMSSLDTNT DFYIGGVSSL NLVNPMAIEN EPVGFQGCIR QVIINNQELQ
LTEFGAKGGS NVGDCDGTAC GYNTCRNGGE CTVNGTTFSC RCLPDWAGNT CNQSVSCLNN
LCLHQSLCIP DQSFSYSCLC TLGWVGRYCE NKTSFSTAKF MGNSYIKYID PNYRMRNLQF
TTISLNFSTT KTEGLIVWMG IAQNEENDFL AIGLHNQTLK IAVNLGERIS VPMSYNNGTF
CCNKWHHVVV IQNQTLIKAY INNSLILSED IDPHKNFVAL NYDGICYLGG FEYGRKVNIV
TQEIFKTNFV GKIKDVVFFQ EPKNIELIKL EGYNVYDGDE QNEVT
