EYS_MACFA
ID EYS_MACFA Reviewed; 3165 AA.
AC A0A2K5V015;
DT 10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 1.
DT 23-FEB-2022, entry version 18.
DE RecName: Full=Protein eyes shut homolog {ECO:0000303|PubMed:27737822};
DE AltName: Full=Epidermal growth factor-like protein 10 {ECO:0000250|UniProtKB:Q5T1H1};
DE Short=EGF-like protein 10 {ECO:0000250|UniProtKB:Q5T1H1};
DE AltName: Full=Epidermal growth factor-like protein 11 {ECO:0000250|UniProtKB:Q5T1H1};
DE Short=EGF-like protein 11 {ECO:0000250|UniProtKB:Q5T1H1};
DE AltName: Full=Protein spacemaker homolog {ECO:0000250|UniProtKB:Q5T1H1};
DE Flags: Precursor;
GN Name=EYS {ECO:0000303|PubMed:27737822};
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
RL Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=27737822; DOI=10.1242/bio.021584;
RA Yu M., Liu Y., Li J., Natale B.N., Cao S., Wang D., Amack J.D., Hu H.;
RT "Eyes shut homolog is required for maintaining the ciliary pocket and
RT survival of photoreceptors in zebrafish.";
RL Biol. Open 5:1662-1673(2016).
RN [3] {ECO:0000305}
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=27846257; DOI=10.1371/journal.pone.0166397;
RA Alfano G., Kruczek P.M., Shah A.Z., Kramarz B., Jeffery G., Zelhof A.C.,
RA Bhattacharya S.S.;
RT "EYS is a protein associated with the ciliary axoneme in rods and cones.";
RL PLoS ONE 11:E0166397-E0166397(2016).
CC -!- FUNCTION: Required to maintain the integrity of photoreceptor cells (By
CC similarity). Specifically required for normal morphology of the
CC photoreceptor ciliary pocket, and might thus facilitate protein
CC trafficking between the photoreceptor inner and outer segments via the
CC transition zone (By similarity). {ECO:0000250|UniProtKB:B8JI71,
CC ECO:0000250|UniProtKB:Q5T1H1}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer
CC segment {ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:27846257}.
CC Cell projection, cilium {ECO:0000269|PubMed:27737822,
CC ECO:0000269|PubMed:27846257}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000269|PubMed:27846257}. Cytoplasm, cytoskeleton, microtubule
CC organizing center, centrosome {ECO:0000250|UniProtKB:Q5T1H1}. Secreted,
CC extracellular space, extracellular matrix, interphotoreceptor matrix
CC {ECO:0000269|PubMed:27737822}. Note=Localizes to discrete puncta at, or
CC adjacent to, the photoreceptor connecting cilium (PubMed:27737822).
CC Highly expressed in cone photoreceptor outer segments (PubMed:27737822,
CC PubMed:27846257). Weakly expressed in rod photoreceptor outer segments
CC (PubMed:27737822). May localize to the cilium axoneme
CC (PubMed:27846257). May also be secreted into the interphotoreceptor
CC extracellular matrix (PubMed:27737822). {ECO:0000269|PubMed:27737822,
CC ECO:0000269|PubMed:27846257}.
CC -!- TISSUE SPECIFICITY: Expressed in retina (at protein level).
CC {ECO:0000269|PubMed:27737822, ECO:0000269|PubMed:27846257}.
CC -!- SIMILARITY: Belongs to the EYS family. {ECO:0000305}.
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DR EMBL; AQIA01051412; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01051413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01051414; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01051415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01051416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01051417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01051418; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01051419; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01051420; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIA01051421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9541.XP_005552676.1; -.
DR VEuPathDB; HostDB:ENSMFAG00000032080; -.
DR OMA; CRDRNNG; -.
DR Proteomes; UP000233100; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0033165; C:interphotoreceptor matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00110; LamG; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR Pfam; PF00008; EGF; 9.
DR Pfam; PF12661; hEGF; 2.
DR Pfam; PF00054; Laminin_G_1; 1.
DR Pfam; PF02210; Laminin_G_2; 4.
DR SMART; SM00181; EGF; 27.
DR SMART; SM00179; EGF_CA; 20.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; SSF49899; 5.
DR SUPFAM; SSF57184; SSF57184; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS00022; EGF_1; 24.
DR PROSITE; PS01186; EGF_2; 16.
DR PROSITE; PS50026; EGF_3; 28.
DR PROSITE; PS01187; EGF_CA; 5.
DR PROSITE; PS50025; LAM_G_DOMAIN; 5.
PE 1: Evidence at protein level;
KW Calcium; Cell projection; Cytoplasm; Cytoskeleton; Disulfide bond;
KW EGF-like domain; Extracellular matrix; Glycoprotein; Reference proteome;
KW Repeat; Secreted; Sensory transduction; Signal; Vision.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..3165
FT /note="Protein eyes shut homolog"
FT /evidence="ECO:0000255"
FT /id="PRO_5014416866"
FT DOMAIN 170..212
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 213..254
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 256..292
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 332..368
FT /note="EGF-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 370..406
FT /note="EGF-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 566..602
FT /note="EGF-like 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 604..641
FT /note="EGF-like 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 643..679
FT /note="EGF-like 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 681..720
FT /note="EGF-like 9; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 733..769
FT /note="EGF-like 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 771..807
FT /note="EGF-like 11; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 809..847
FT /note="EGF-like 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 849..888
FT /note="EGF-like 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 890..926
FT /note="EGF-like 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 928..964
FT /note="EGF-like 15; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 966..1002
FT /note="EGF-like 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1004..1040
FT /note="EGF-like 17; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1042..1077
FT /note="EGF-like 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1079..1115
FT /note="EGF-like 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1117..1159
FT /note="EGF-like 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1161..1197
FT /note="EGF-like 21; calcium-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1883..2063
FT /note="Laminin G-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 2099..2140
FT /note="EGF-like 22"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2145..2339
FT /note="Laminin G-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 2335..2368
FT /note="EGF-like 23"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2371..2408
FT /note="EGF-like 24"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2419..2609
FT /note="Laminin G-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 2610..2646
FT /note="EGF-like 25"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2648..2689
FT /note="EGF-like 26"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2717..2895
FT /note="Laminin G-like 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DOMAIN 2896..2932
FT /note="EGF-like 27"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2933..2970
FT /note="EGF-like 28"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2975..3165
FT /note="Laminin G-like 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 252
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 269
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 272
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 311
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 343
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 382
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 506
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 520
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 521
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 566
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 573
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 611
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 628
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 654
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 745
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 782
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 783
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 805
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 862
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 863
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 940
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1509
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1906
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1941
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2033
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2170
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2347
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2412
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2453
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2484
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2506
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2532
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2635
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2775
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2800
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2824
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2914
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2932
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 2971
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3006
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3036
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3057
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3073
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 3082
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 174..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 183..200
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 202..211
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 217..228
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 222..242
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 244..253
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 260..270
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 265..280
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 282..291
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 341..356
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 358..367
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 396..405
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 592..601
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 608..620
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 629..640
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 669..678
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 685..696
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 690..705
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 707..719
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 759..768
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 775..786
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 780..795
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 797..806
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 813..824
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 818..835
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 837..846
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 853..866
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 860..876
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 878..887
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 894..905
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 899..914
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 916..925
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 932..943
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 937..952
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 954..963
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 970..981
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 975..990
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 992..1001
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1008..1019
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1013..1028
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1030..1039
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1046..1056
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1051..1065
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1067..1076
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1083..1094
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1088..1103
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1105..1114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1121..1137
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1131..1147
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1149..1158
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1165..1176
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1170..1185
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1187..1196
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2037..2063
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DISULFID 2103..2114
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2108..2128
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2130..2139
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2308..2339
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DISULFID 2339..2350
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2344..2359
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2375..2386
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2380..2396
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2398..2407
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2576..2609
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DISULFID 2614..2625
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2619..2634
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2636..2645
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2652..2668
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2662..2677
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2679..2688
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2868..2895
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00122"
FT DISULFID 2900..2911
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2905..2920
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2922..2931
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2937..2948
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2942..2958
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 2960..2969
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3165 AA; 351050 MW; 8FE6949946E3435E CRC64;
MTDKSIIILS LMVFHSSFIN GKTCRRELVE EWHPQPSSHV VNWTLTENIC LDYYRDCWFL
GVNTKIDTSG NQVVPQICPL QIQLGDILVI SSEPSLQFPE INLMNVSETS FIGCVQNTTT
EDQLLFGCRL KGMHTVNSKW LSVGTHYFIT VMASGPSPCP LGLRLNVTVK QQFCQESLSS
EFCSGHGKCL SEAWSKTYSC HCQPPFSGKY CQELDACSFK PCKNDGSCIN KRGNWDEQGY
ECVCHPPFTG KNCSEIIVQC QPHVCFHGNC SNITSNSFIC ECDEQFSGPF CEVSTKPCVS
LLCWKRGICP NSSSAYTYEC PKGPSSQNGE TDVSECSLIL CENGTDGIKI SNDVMCICSP
IFTDLLCKSF QTSCESFPLK NNATFKKCEK DYHCSCMSGF TGKNCEKVID HCKLLSINCL
NEEWCFNIIG RFKYVCIPGC TKNPFWFLKN VHLIHLHPCY YGITFHGICQ DKGPAHFEYV
WQLGFTGSEG EKCQGVIDAY FFLTANCTED AIYVNNPEDN NSSCSFPCEG TKEICANGCS
CLSEEDNQEY RYLCFLRWTS NMYLENITDD QENKSQHEAI CEDEINRPRC SCSLSYIGRL
CVVNVDYCLG NQSISVHGLC LALSHNCNCS DLQKYEGNIC EIDIEDCKSV SCKNGTTSIH
LRGYFFYKCV PGFKGTRCEI DLDECALHPC KSGATCIDQP GNYFCQCGPP FKVVDGFSCL
CNPGYVGTRC EQNIDNCILN AFEHNSTYKD LHLSYQCVCL SGWEGNFCEQ ESNECKMNPC
KNNSTCTDLY KSYRCECTSG WTGQNCSEEI NECDSDPCMN GGLCHESTIP GQFVCLCPPL
YTGQFCHQRY NPCDLLNNPC RNNSTCLALV DGNQHCICRE EFEGKHCEID VKECLFLSCQ
DYGDCEDMVN NFRCICRPGF SGSLCEIEIN ECSSEPCKNN GTCVDLTNRF FCNCEPGYHG
PFCELEVNKC KISPCLDEEN CVYRTDRYNC LCAPGYTGIN CEINLDECLS EPCLHDGVCI
DGINHYTCDC KSGFFGTHCE TNANDCLSNP CLHGRCTEPI NEYPCSCDAD GTSIQCKIKI
NDCTSMPCMN EGFCQKSAHG FTCICPRGYT GAYCEKSIDN CAEPELNSVI CLNGGICVDG
PGHTFDCRCL PGFSGQFCEI NINECSSSPC LHGANCEDHI NGYVCKCQPG WSGHHCEKEL
ECVPNSCVHQ LCMENEPGST CLCTPGFMTC SIGLLCGDEI RRITCLTPSF QRTDPISTQT
HTVPPSETLV SSFPSIKATR IPTIMDTYPV DQGPKQTGIV KHDILPTTGL ATLRISTPLK
SYLLEELIVT RELSAKHSLL SSTDVSSSPF LNFGIHDPAQ IVQDKTSVSH MRIRTSAATL
GFFFPDRRAR TSFIRSSLMS DFIFPTQSLL FENYQTVASS ATPTTSVIRS IPGADIELNR
HSLLSRGFLL TAASISATPV VSRGAQEDIK EYSAVSLISR REHWRSLISS MSPIFPAKKI
ISKQVTILNS SALHRFGTKA FIPSEYQAIT EASSNQRLTN IKSQAADSLR ELSQTCATCS
MTEIKSSHEF SDQVLHSKQS HFYETFWMNS AILASWYALM GAQTITSGHS FSSATEITPS
VAFTEVPSLF PSKKSAKRTI LSSSLEESIT LSSNLDVNLC LHKTCLSIVP SQTISSDLMN
SDLTSELTTD ELSVSENILK LLKIRQYGIT TGPTEVLNQD SLLDMEKSKG SHTPFKLHPS
DSSLDLELNL RSYPDVTLKT YSEITLANDL KNNLPPLTGS VPDFSEVTTN VAFYTVSATP
ALPIQTSSSM SVITPDWPYF IDYMTSLNKE VKTYSEWSKW ELQPSVQYQE FPTASWHLPF
TRSLTLSSLE SIVAPQQLMI SDFSCVCYYG DSYLEFQNVV LNPQNNISLE FQTFSSYGLL
LYVKQDSNLV DGFFIQLSIE NGTLKYHFYC PGEAKFKSIN TAIRVDDGQK YTLLIRQELD
PCKAELTILG RNTQTCESIN HVLGKPLPKS GSVFIGGFPD LRGKIQMPVP VKNFTGCIEV
IEINNWRSFI PSKAVRNYHI NNCRSQGLML SPTASFVDAS DVTQGVDAMW TSVSPSVAAP
SVCQEDVCHN GGTCRPIFLS SGIVSFQCDC PLHFTGRFCE KDAGLFFPSF SGNSYLELPF
LNFVLEKEHN RTVTIYLTIK TNSLNGTILY SNGNNFGKQF LHLFLVEGKP SVKYGCGNSQ
NILTVSANYS INTNAFTPIT VRHTMPIGSP GVVCMIEMTA DGKPPVQKKD TEISHASQVY
FESMFLGHIP ENVQIHKKAG SVYGFRGCIL DLQINNKEFF IIDEARRGKN IENCHVPWCA
HHLCRNNGTC LSDSENLFCE CPRLYSGKLC QFASCENNPC GNGATCVPKS GTDIICLCPY
GRSGPLCTDA INITQPRFSG TDAFGYTSFL AYSRISDISF HYEFHLKFQL ANNHSALQNN
LIFFTGQKGH GLNGDDFLAV GLLNGSVVYS YNLGSGIASI RSDPLNLSLG VHTVHLGKFF
QEGWLKVDDH KNKSIIAPGR LVGLNVFSQF YVGGYSEYTP DLLPNGADFK NGFQGCIFTL
QVRTEKDGHF RGLGNPEGHP NAGRSVGQCH ASPCSLMKCG NGGTCIESGT SVYCNCTTRW
KGAFCTETVS ICDPEHDPPH HCSRGATCIS LPHGYTCFCP LGTTGIYCEQ ALILTVILEK
PKPAEWKVKK EALSISDPSF RSSELSWMSF ASFHVRKKTH IQLQFQPLAA DGILFYAAQH
LKAQSGDFLC ISLVNGSVQL RYNLGDRTII LETLQKVTIN GSTWHIIKAG RVGAEGYLDL
DGINVTEKAS TKMSSLDTNT DFYIGGVSSL NLVNPMAIEN EPVGFHGCIR QVIINYQELQ
LTEFGAKGGS NVGDCDGTAC GYNTCRNGGE CRVNGTTFSC RCLPDWAGNI CNQSAYCLNN
LCLHQSLCIP DQSFSYSCLC TLGWVGRYCE NKTSFTTAKF MGNSYIKYID PNYRMRNLQF
TTISLNFSTT KTEGLIIWMG IAQNEENDFL AIGLHNQTLK IAVNLGERIS VPMSYNNGTF
CCNKWHHVIV IQNQTLIKAY VNNSLILSED IDPHKNFVAL NYEGICYLGG FEYGRKVNIV
TQEIFKTNFV GKIKDVVFFQ DPKKIELIKL EGYNVYDGDE QNEVT
