ID   EZRA_ALKHC              Reviewed;         561 AA.
AC   Q9K802;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=BH3205;
OS   Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS   / JCM 9153 / C-125) (Bacillus halodurans).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX   NCBI_TaxID=272558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX   PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA   Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA   Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT   "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT   and genomic sequence comparison with Bacillus subtilis.";
RL   Nucleic Acids Res. 28:4317-4331(2000).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; BA000004; BAB06924.1; -; Genomic_DNA.
DR   PIR; E84050; E84050.
DR   RefSeq; WP_010899348.1; NC_002570.2.
DR   AlphaFoldDB; Q9K802; -.
DR   SMR; Q9K802; -.
DR   STRING; 272558.10175828; -.
DR   EnsemblBacteria; BAB06924; BAB06924; BAB06924.
DR   KEGG; bha:BH3205; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_1_0_9; -.
DR   OMA; FRSQNHI; -.
DR   OrthoDB; 670472at2; -.
DR   Proteomes; UP000001258; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..561
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_0000172869"
FT   TOPO_DOM        1..3
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        4..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        23..561
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          98..130
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          166..214
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          251..465
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   561 AA;  65161 MW;  C5C315CA960F0666 CRC64;
     MWIVVFSLLV LTVTFFVYGA LRRKAFYKRV DKLEDWKNDI LQRPIPDEIG KVKGLTMSGE
     TEEKFEVWRS DWDDIVGVIL PNVEEQLFDV EDFANKYRFQ KAKALLDTIE QRLHSIEEQL
     KIMVDDIQVL VQSEEQNRTE IGSVRELQQK LIKEAITRRG SLSSSAKVFD EKLEKANELL
     QAFDERTEKG NYIQASEVLE EAKELLGQIE HLLKIVPGLF VELQTNIPAE LTNLKNGLRD
     MEEAGFFLET FAIDSQMERL EEKRVELLEQ LTVLECNGME EEINFIEESM EQMFELLEKE
     VEAKNEITIL LPNLREDLTK TEEKLTHLKE ETESVQLSYR LAEEELVFQQ KLGKELKELR
     QQLQVIDEVT EEQKQTFSSV RSMLEEWREG LTACQNKIEQ AQESLNSLRK DELKAKEELK
     QLKEKLLEDK RLVQKSNIPG LPETLLHRLE DGEQKLAQAI AKLSDVPLEM GRVTALVDEA
     QGLIHENSSI LHETIEKARL AEHVIQYGNR YRSRSAEVKK RLSNAEELFR AFEYDEAIEM
     AVQAIEPFEK DVLEKVQHLA G