ID   EZRA_BACC2              Reviewed;         570 AA.
AC   B7IK49;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   OrderedLocusNames=BCG9842_B0477;
OS   Bacillus cereus (strain G9842).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=405531;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G9842;
RA   Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA   Ravel J., Sutton G.;
RT   "Genome sequence of Bacillus cereus G9842.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; CP001186; ACK95187.1; -; Genomic_DNA.
DR   RefSeq; WP_000377314.1; NC_011772.1.
DR   AlphaFoldDB; B7IK49; -.
DR   SMR; B7IK49; -.
DR   EnsemblBacteria; ACK95187; ACK95187; BCG9842_B0477.
DR   KEGG; bcg:BCG9842_B0477; -.
DR   HOGENOM; CLU_034079_1_0_9; -.
DR   OMA; FRSQNHI; -.
DR   Proteomes; UP000006744; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane; Septation;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..570
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_1000132703"
FT   TOPO_DOM        1..6
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        7..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        26..570
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          116..149
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          273..304
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          355..429
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   570 AA;  66276 MW;  889115FA120C920D CRC64;
     MDSILTIVII VVSSILVLLM IELVIRNRSY KDIEALEQWK QEIKDKPVAD ELKRVKDLNM
     TGQTEELFGK WREEWDEIVS TTLPKADKDL AQARKFASQF SFRKAKHAMN ESISGLDDAD
     NRITGVLNEL QQLLESHEKN SSEIEGLRDT YRSMKKSVLA HRHMYGAAEQ KIEEMLDAES
     NKFKSFEEAT DNGDYLKARE IVISLEEGLA GLEIIIHQIP DLLVECQATL PVQLEDLLQG
     HNDMVRQGYV LEYLEVPKEV RDMTTQLNTC LMDIQELHIT EAAEKVEDLK TRLDGFYDQL
     EQEVHARHYV EQKTLSVYED LEEIRIETIE TKTETQLVKQ SYQLQDKDIE SQKVIEKQMH
     ILTKRFEMLQ LRVAEQDIAF SIIREELEEV YEQCETLKIL HAEYKEMLQT MRKEEFEARE
     KLQEMRNTIF ETKRFMQKSN LPGLPESIME DLKRGQMAMQ AVYEQLEVKP LNMNAVNSSL
     EEAYTTVNGV AEMTEELIGQ AYLVEKLIQY GNRYRSHDES LAESLNYAEK LFREYQYDAA
     LEQAASVLEQ LEPGVVQKIA EYVDNEQTLS