ID   EZRA_BACMK              Reviewed;         569 AA.
AC   A9VKG1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   OrderedLocusNames=BcerKBAB4_4480;
OS   Bacillus mycoides (strain KBAB4) (Bacillus weihenstephanensis).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=315730;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KBAB4;
RX   PubMed=17434157; DOI=10.1016/j.cbi.2007.03.003;
RA   Lapidus A., Goltsman E., Auger S., Galleron N., Segurens B., Dossat C.,
RA   Land M.L., Broussolle V., Brillard J., Guinebretiere M.-H., Sanchis V.,
RA   Nguen-the C., Lereclus D., Richardson P., Wincker P., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "Extending the Bacillus cereus group genomics to putative food-borne
RT   pathogens of different toxicity.";
RL   Chem. Biol. Interact. 171:236-249(2008).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; CP000903; ABY45638.1; -; Genomic_DNA.
DR   RefSeq; WP_002143389.1; NC_010184.1.
DR   AlphaFoldDB; A9VKG1; -.
DR   SMR; A9VKG1; -.
DR   STRING; 315730.BcerKBAB4_4480; -.
DR   EnsemblBacteria; ABY45638; ABY45638; BcerKBAB4_4480.
DR   KEGG; bwe:BcerKBAB4_4480; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_1_0_9; -.
DR   OMA; FRSQNHI; -.
DR   Proteomes; UP000002154; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane; Septation;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..569
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_1000132706"
FT   TOPO_DOM        1..6
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        7..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        26..569
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          115..150
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          272..304
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          383..429
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   569 AA;  66398 MW;  EB1B3593A6473E1F CRC64;
     MDSILTIVII VVSSILVLLM IELVIRNRSY KDIEALEQWK QEIKDKPVAD ELKRVKDLNM
     TGQTEELFGK WREEWDEIVS TSLPKAEKDL GQARKFASQF SFRKAKHAMK ESISGLDDAD
     NRITDILNEL QQLLESHEKN SAEIEGLRDT YRSMKKSVLA HRHMYGAAEQ KIEEMLDVES
     EKFKTFEEAT DNGDYLKARE IVISLEEGLA SLEIVIHQIP DLLVECQATL PVQLEDLLQG
     HDDMIRQGYV LEYLEIPKEV RDMTTQLHTC LMDIQELHIT EAAEKVENLK TRLDSFYDQL
     EQEVHAKHYV EQKTLSVYED LEEIRTETIE TKIETQLVKQ SYQLQDKDIE SQKVIEKQMH
     ILMKRFEVLQ IRVAEQDIAF SIIREELEEV YEQCETLKVL HAEYKEMLQT MRKEEFEARE
     KLQEMRNTIF ETKRFMQKSN LPGLPESIME DLQKGQMAMQ AVYEQLEVKP LNMNTVNSSL
     EEAYTVVNGV SEMTEEVIGQ AYLVEKLIQY GNRYRSHDEN LAESLNYAEK LFREYQYDAA
     LEQAASILEQ LEPGVVQKIA EYVDNEQTL