ID   EZRA_BACP2              Reviewed;         567 AA.
AC   A8FG97;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2007, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=BPUM_2606;
OS   Bacillus pumilus (strain SAFR-032).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=315750;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SAFR-032;
RX   PubMed=17895969; DOI=10.1371/journal.pone.0000928;
RA   Gioia J., Yerrapragada S., Qin X., Jiang H., Igboeli O.C., Muzny D.,
RA   Dugan-Rocha S., Ding Y., Hawes A., Liu W., Perez L., Kovar C., Dinh H.,
RA   Lee S., Nazareth L., Blyth P., Holder M., Buhay C., Tirumalai M.R., Liu Y.,
RA   Dasgupta I., Bokhetache L., Fujita M., Karouia F., Eswara Moorthy P.,
RA   Siefert J., Uzman A., Buzumbo P., Verma A., Zwiya H., McWilliams B.D.,
RA   Olowu A., Clinkenbeard K.D., Newcombe D., Golebiewski L., Petrosino J.F.,
RA   Nicholson W.L., Fox G.E., Venkateswaran K., Highlander S.K.,
RA   Weinstock G.M.;
RT   "Paradoxical DNA repair and peroxide resistance gene conservation in
RT   Bacillus pumilus SAFR-032.";
RL   PLoS ONE 2:E928-E928(2007).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC       Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; CP000813; ABV63264.1; -; Genomic_DNA.
DR   RefSeq; WP_012010900.1; NZ_VEIC01000003.1.
DR   AlphaFoldDB; A8FG97; -.
DR   SMR; A8FG97; -.
DR   STRING; 315750.BPUM_2606; -.
DR   EnsemblBacteria; ABV63264; ABV63264; BPUM_2606.
DR   KEGG; bpu:BPUM_2606; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_1_0_9; -.
DR   OMA; FRSQNHI; -.
DR   OrthoDB; 670472at2; -.
DR   Proteomes; UP000001355; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..567
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_1000062106"
FT   TOPO_DOM        1..2
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        3..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        22..567
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          108..185
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          243..375
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          402..529
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   567 AA;  66335 MW;  0E34F5C63BAC581C CRC64;
     MEFIIGLIVI LLALFSVGYF LRKNIYKEID RLEAWKIEIL NRSIVEEISK IKHLKMTGET
     EQFFERWRAE WDDIVTAHLP KVEELLYDAE EYSDKYRFSK AKQVLTHIED LLSAADSNIE
     DILKEIADLV TSEEQNRKDI EKVKEQYQTV RKNLLAYSHL YGTLYDKMEQ DLDEAWEGIK
     QYEEETENGN YMKARKILLE QDRRLDQLQL YINDVPKLIA DCKQTVPGQL TKLKDGYQEM
     SEKGYKLEHI QITKELETLN KQLARAEKLL IDELNLEEAS SILQMIDDAI ETLYDQLEAE
     VEAGQEIKSR MPELTEAFEK LEQDHTQTKA ETALVKESYK LTAGELDQQK AFEKRLEEIE
     KLMKQIREKL DRDHVAYSLL MDEINQLETF IEDAKALHDT FKGHLQSLRK EELQARETLA
     ELKTMLTDTV RQLHKSNIPG VPAEMKERAE KAQEMIHQVH EQLENLPLNM PAVNQQLKEA
     SDTVRNVVDE TEEMLSKVDQ IERIIQYGNR FRSQNHILSE QLKEAERRFY AYDYNGSFDI
     AAAAVEKASP GAVQKLLAQQ EKEYQHQ