EZRA_GEOTN
ID EZRA_GEOTN Reviewed; 567 AA.
AC A4IRU1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=GTNG_2700;
OS Geobacillus thermodenitrificans (strain NG80-2).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus.
OX NCBI_TaxID=420246;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NG80-2;
RX PubMed=17372208; DOI=10.1073/pnas.0609650104;
RA Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X.,
RA Han W., Peng X., Liu R., Wang L.;
RT "Genome and proteome of long-chain alkane degrading Geobacillus
RT thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00728}.
CC Note=Colocalized with FtsZ to the nascent septal site.
CC {ECO:0000255|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC Rule:MF_00728}.
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DR EMBL; CP000557; ABO68045.1; -; Genomic_DNA.
DR RefSeq; WP_008880897.1; NC_009328.1.
DR AlphaFoldDB; A4IRU1; -.
DR SMR; A4IRU1; -.
DR STRING; 420246.GTNG_2700; -.
DR PRIDE; A4IRU1; -.
DR EnsemblBacteria; ABO68045; ABO68045; GTNG_2700.
DR KEGG; gtn:GTNG_2700; -.
DR eggNOG; COG4477; Bacteria.
DR HOGENOM; CLU_034079_1_0_9; -.
DR OMA; FRSQNHI; -.
DR OrthoDB; 670472at2; -.
DR Proteomes; UP000001578; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane; Septation;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..567
FT /note="Septation ring formation regulator EzrA"
FT /id="PRO_1000045897"
FT TOPO_DOM 1..2
FT /note="Extracellular"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT TRANSMEM 3..21
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT TOPO_DOM 22..567
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT COILED 97..158
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT COILED 268..304
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT COILED 346..497
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ SEQUENCE 567 AA; 66201 MW; EC9EC261254CA49D CRC64;
MEIVWIVLLL GAGVIIYNHM YRKKMYREID RLEAWKIELM NRPVPDELAK VKQLNMTGET
EQLFERWRQQ WDEIVAVKLP NVEEQLFDTE TFLDKYRYRQ ARKLIGQIED GLRRLEEEVH
QIIDEVNELI GSEEQSRTEI EELRAVHREA KKTLLAYRYT FGAAADLLDV RLTEAEKQFE
SFAKLTEAGN YLAARGVVQE LKQELDSLAT MMEEIPALLS ECQTSLPAQL AELADGYREM
EQSGYILDHL HIERTLAEKQ EKIGQCLAMI GELRIEEAKQ TVAELKEEID TLYDLLEKEV
LANQYVQTEM PRIGGMLTEL AAEAKETSAE AMFVQQSYHL PPSDLEKYRS IEKQMHQLQK
RFLLIEDRVA EAKTAYSLLR EELEQLVGQI DMMKEEHEQF RLMLQALRKD ELIAREKLDD
MRKKLSESLR LVQKSRLPGL PEPYALELTE AKNSLQNVAA RLEEKPLDMP AVDRALEEAK
VSVERLYERT VEMIEQASLA ERAIQYGNRY RRRYPAVHKG LEEAEFLFRH YDYEEALRQA
VATIESVEPG AFDRVQKLWQ ADNEDEQ
