ID   EZRA_LACLA              Reviewed;         576 AA.
AC   Q9CDR6;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=LL2151;
GN   ORFNames=L7722;
OS   Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Lactococcus.
OX   NCBI_TaxID=272623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA   Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; AE005176; AAK06249.1; -; Genomic_DNA.
DR   PIR; G86893; G86893.
DR   RefSeq; NP_268308.1; NC_002662.1.
DR   RefSeq; WP_003132670.1; NC_002662.1.
DR   AlphaFoldDB; Q9CDR6; -.
DR   SMR; Q9CDR6; -.
DR   STRING; 272623.L7722; -.
DR   PaxDb; Q9CDR6; -.
DR   EnsemblBacteria; AAK06249; AAK06249; L7722.
DR   GeneID; 66443142; -.
DR   KEGG; lla:L7722; -.
DR   PATRIC; fig|272623.7.peg.2310; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_2_0_9; -.
DR   OMA; FRSQNHI; -.
DR   Proteomes; UP000002196; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..576
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_0000172872"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        8..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        27..576
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          105..134
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          277..301
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   576 AA;  66129 MW;  A0A2EF10C72CB39D CRC64;
     MSSTVIILIV VLLVILVAFY AFAILMRKKT EDRILALEER KESLFDLPVQ EEIDSVKKMH
     LVGQSQTIFR EWNQKWLDLS SNSFADLEEH IFEAEQLNDS FHFFRARESV ADSEAQIELM
     EGDVEGIRQG VAQLVEQEKR NSNKIQESLD LYDNLRSDIA DNADLYGTVI TELEKHLANI
     ETEFSQFVTL NSTGDPIEAA EVLETAEEHT IALRAITEQI PSFIKTIEKD VPKRLEELQE
     ASDKFVAEEY ILPDNVNIKE RMDDLHDHLV ESSSLLEQFE LDRVEAELGL IQEKVEELYA
     IFEREYSARR NVEKRSSVLK EYIEHIRANN KNLLLEIDHV TQAYILSGNE KGYVRGYQEH
     LESLDSDVDE ILGNIQAKTM PYSILSRRVN SVVNALEDIE KNQIKISDTL TGLRDEERAA
     QEIAERFDSE LRTIKRYVEK CNLPGLPKDY LDLFFTTGDR VQNLFKELGR VRINIDTINH
     LVDVSTEDMH VLKEATTNLT DHAVLAEQLI QYANRYKAAN EQVAQGISRA LQLFENSRDY
     DGSFDEISKT LELVEPGAAS RISGVYFKNK PTPDYL