AHL18_ARATH
ID AHL18_ARATH Reviewed; 265 AA.
AC Q9LZX7;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=AT-hook motif nuclear-localized protein 18 {ECO:0000312|EMBL:FAA00289.1};
GN Name=AHL18 {ECO:0000303|PubMed:15604740};
GN OrderedLocusNames=At3g60870 {ECO:0000312|Araport:AT3G60870};
GN ORFNames=T4C21_280 {ECO:0000312|EMBL:CAB82691.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP IDENTIFICATION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=15604740; DOI=10.1007/s11103-004-3249-5;
RA Fujimoto S., Matsunaga S., Yonemura M., Uchiyama S., Azuma T., Fukui K.;
RT "Identification of a novel plant MAR DNA binding protein localized on
RT chromosomal surfaces.";
RL Plant Mol. Biol. 56:225-239(2004).
RN [4]
RP FUNCTION.
RX PubMed=19517252; DOI=10.1007/s11103-009-9507-9;
RA Xiao C., Chen F., Yu X., Lin C., Fu Y.F.;
RT "Over-expression of an AT-hook gene, AHL22, delays flowering and inhibits
RT the elongation of the hypocotyl in Arabidopsis thaliana.";
RL Plant Mol. Biol. 71:39-50(2009).
RN [5]
RP GENE FAMILY, AND DOMAIN PPC.
RX PubMed=24218605; DOI=10.1073/pnas.1219277110;
RA Zhao J., Favero D.S., Peng H., Neff M.M.;
RT "Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by
RT interacting with each other via the PPC/DUF296 domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E4688-E4697(2013).
CC -!- FUNCTION: Transcription factor that specifically binds AT-rich DNA
CC sequences related to the nuclear matrix attachment regions (MARs) (By
CC similarity). Acts redundantly with AHL22, AHL27 and AHL29 in the
CC regulation of flowering and regulation of the hypocotyl elongation
CC (PubMed:19517252). {ECO:0000250|UniProtKB:Q8VYJ2,
CC ECO:0000269|PubMed:19517252}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- DOMAIN: The PPC domain mediates interactions between AHL proteins.
CC {ECO:0000269|PubMed:24218605}.
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DR EMBL; AL162295; CAB82691.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE80119.1; -; Genomic_DNA.
DR EMBL; BR000354; FAA00289.1; -; mRNA.
DR PIR; T47898; T47898.
DR RefSeq; NP_191646.1; NM_115951.2.
DR AlphaFoldDB; Q9LZX7; -.
DR SMR; Q9LZX7; -.
DR STRING; 3702.AT3G60870.1; -.
DR PaxDb; Q9LZX7; -.
DR PRIDE; Q9LZX7; -.
DR ProteomicsDB; 244966; -.
DR EnsemblPlants; AT3G60870.1; AT3G60870.1; AT3G60870.
DR GeneID; 825258; -.
DR Gramene; AT3G60870.1; AT3G60870.1; AT3G60870.
DR KEGG; ath:AT3G60870; -.
DR Araport; AT3G60870; -.
DR TAIR; locus:2101916; AT3G60870.
DR eggNOG; ENOG502QRBV; Eukaryota.
DR HOGENOM; CLU_039808_2_0_1; -.
DR InParanoid; Q9LZX7; -.
DR OMA; VGGQEHQ; -.
DR OrthoDB; 1369071at2759; -.
DR PhylomeDB; Q9LZX7; -.
DR PRO; PR:Q9LZX7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LZX7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IBA:GO_Central.
DR GO; GO:0009908; P:flower development; IEA:UniProtKB-KW.
DR GO; GO:0048364; P:root development; IMP:TAIR.
DR GO; GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
DR CDD; cd11378; DUF296; 1.
DR InterPro; IPR014476; AHL15-29.
DR InterPro; IPR005175; PPC_dom.
DR PANTHER; PTHR31100; PTHR31100; 1.
DR Pfam; PF03479; PCC; 1.
DR PIRSF; PIRSF016021; ESCAROLA; 1.
DR PROSITE; PS51742; PPC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Flowering; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..265
FT /note="AT-hook motif nuclear-localized protein 18"
FT /id="PRO_0000432036"
FT DOMAIN 83..217
FT /note="PPC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01078"
FT DNA_BIND 59..71
FT /note="A.T hook"
FT /evidence="ECO:0000305"
FT REGION 1..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 265 AA; 28412 MW; 31162D06E4BAD0AD CRC64;
MDEVSRSHTP QFLSSDHQHY HHQNAGRQKR GREEEGVEPN NIGEDLATFP SGEENIKKRR
PRGRPAGSKN KPKAPIIVTR DSANAFRCHV MEITNACDVM ESLAVFARRR QRGVCVLTGN
GAVTNVTVRQ PGGGVVSLHG RFEILSLSGS FLPPPAPPAA SGLKVYLAGG QGQVIGGSVV
GPLTASSPVV VMAASFGNAS YERLPLEEEE ETEREIDGNA ARAIGTQTQK QLMQDATSFI
GSPSNLINSV SLPGEAYWGT QRPSF
