ID   EZRA_LACPL              Reviewed;         573 AA.
AC   Q88UX2; F9UQN4;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=lp_2328;
OS   Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)
OS   (Lactobacillus plantarum).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactiplantibacillus.
OX   NCBI_TaxID=220668;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA   Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D., Kuipers O.P.,
RA   Leer R., Tarchini R., Peters S.A., Sandbrink H.M., Fiers M.W.E.J.,
RA   Stiekema W., Klein Lankhorst R.M., Bron P.A., Hoffer S.M.,
RA   Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B., De Vos W.M.,
RA   Siezen R.J.;
RT   "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX   PubMed=22156394; DOI=10.1128/jb.06275-11;
RA   Siezen R.J., Francke C., Renckens B., Boekhorst J., Wels M.,
RA   Kleerebezem M., van Hijum S.A.;
RT   "Complete resequencing and reannotation of the Lactobacillus plantarum
RT   WCFS1 genome.";
RL   J. Bacteriol. 194:195-196(2012).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; AL935263; CCC79523.1; -; Genomic_DNA.
DR   RefSeq; WP_003641477.1; NC_004567.2.
DR   RefSeq; YP_004890037.1; NC_004567.2.
DR   AlphaFoldDB; Q88UX2; -.
DR   SMR; Q88UX2; -.
DR   STRING; 220668.lp_2328; -.
DR   EnsemblBacteria; CCC79523; CCC79523; lp_2328.
DR   GeneID; 57025860; -.
DR   KEGG; lpl:lp_2328; -.
DR   PATRIC; fig|220668.9.peg.1968; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_2_0_9; -.
DR   OMA; FRSQNHI; -.
DR   PhylomeDB; Q88UX2; -.
DR   BioCyc; LPLA220668:G1GW0-2007-MON; -.
DR   Proteomes; UP000000432; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..573
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_0000172873"
FT   TOPO_DOM        1..2
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        3..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        22..573
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          100..188
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          317..364
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          416..488
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   573 AA;  64497 MW;  1B050AC94C2A9E2C CRC64;
     MQVAIGIVVV AIVIYAAVKG FQFYIDKQVR QLTERQQALV KQSQTTDFEK IEQLGLTGGS
     LAKLEALQSA GQEVDNDQLP AVSEQLTAIT SQARGIRFLD AQQNLKKVAA TLDTIEQRQA
     EIRQGLQALD DADAAHRQAV ASLEKKYQNI RKTLLSQNFS FGPSIDKLED QLANLESDFD
     HFSELAKAGD HDAAEKVLDQ LHHDTGTLEM DIDRIPPIYK DLVSGFPDQL AELASGYQQL
     TAQHFHFEVE SIEPEIKALQ QAIDDNIALL GDLKVTDAEN GNHAIEKRID HLYDVMQAEI
     DAKAVVDQQQ EEISKFLTHA MNQNHRLQIE LDRLAQSYTL NNGEVERTRE LNEQLKNIEA
     VYQADVTAIT SKQAVFSEIA AHFAEQDEQL KGIEEEQVAI NKGVASLTAE ESKAHETLQR
     FDFEIHAIKR QVENLNLPGL PKDYLDYFKV VAKEIERLDH DINKLVINMD DITKQLIVIQ
     ADMATLKEKT SDLTDAAVMA EQLLQYANRY KTNHEEVQEA SVEAQRLFTE THDYARSLEV
     IATAVDKVDP GSYKRIEDSY YANKQADKMN DEA