ID   EZRA_LISMO              Reviewed;         571 AA.
AC   Q8Y6T8;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=lmo1594;
OS   Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX   NCBI_TaxID=169963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-679 / EGD-e;
RX   PubMed=11679669; DOI=10.1126/science.1063447;
RA   Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F.,
RA   Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A.,
RA   Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E.,
RA   Dominguez-Bernal G., Duchaud E., Durant L., Dussurget O., Entian K.-D.,
RA   Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W.,
RA   Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U.,
RA   Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A.,
RA   Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B.,
RA   Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N.,
RA   Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P.;
RT   "Comparative genomics of Listeria species.";
RL   Science 294:849-852(2001).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; AL591979; CAC99672.1; -; Genomic_DNA.
DR   PIR; AB1274; AB1274.
DR   RefSeq; NP_465119.1; NC_003210.1.
DR   RefSeq; WP_010989755.1; NZ_CP023861.1.
DR   AlphaFoldDB; Q8Y6T8; -.
DR   SMR; Q8Y6T8; -.
DR   STRING; 169963.lmo1594; -.
DR   PaxDb; Q8Y6T8; -.
DR   EnsemblBacteria; CAC99672; CAC99672; CAC99672.
DR   GeneID; 986850; -.
DR   KEGG; lmo:lmo1594; -.
DR   PATRIC; fig|169963.11.peg.1636; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_2_0_9; -.
DR   OMA; FRSQNHI; -.
DR   PhylomeDB; Q8Y6T8; -.
DR   BioCyc; LMON169963:LMO1594-MON; -.
DR   Proteomes; UP000000817; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..571
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_0000172876"
FT   TOPO_DOM        1..3
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        4..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        23..571
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          248..298
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          326..374
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          400..437
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          478..529
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   571 AA;  66520 MW;  41482698D961B748 CRC64;
     MYYMLIGFII VVIAVIGAGY ILKRKHYQRI NELEEKKIKL RERPVIDELS KVKKLKLTGQ
     TEALFESWRS SWDEIETRLF PDLEEVLLEA EMNTDRYKFR SATHAENDIE QMLVVIEKQM
     DQILGGLKEL LISEEKNAKE SRATKEKFAE LRREVLTRGF KLGETLPYIE TKLSELSESL
     NSYDSLTDQG DHLEAREIVI VVQKEMQVIE AQMERIPSLL HETDTILPEE MTKLRAGYEE
     MVRKGYYLAQ MELDKEISRM KNQIDKMKKN VINLDLDEAE QGVEELHNEI DLFYDTLEHE
     AEARHFVKEN HSPTSDKLQR QNAVSDALAE QITEVKQTYH VAEDDLAVYL KTSAKLSEAK
     ENFEQLTALI ASGEIAYSAA QDTLKEIDAA LITISTEQDK FAEELRSLRK DELEARDDAE
     RMRRAIITLD RKMERERLPG LPEEYLSLRE HMGESIDALE KRLEEKPLNM KAVSQDWRIA
     EEDLTHLTEK AEEMMENVRL VEHVIQYANR YRLRNKELAD ELVQAENHFY NDYQYKKALE
     IAVTALEKVE TGAFKKVEKA YESKVSVDDI E