AHL19_ARATH
ID AHL19_ARATH Reviewed; 315 AA.
AC Q9SR17;
DT 04-MAR-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 120.
DE RecName: Full=AT-hook motif nuclear-localized protein 19 {ECO:0000312|EMBL:FAA00290.1};
GN Name=AHL19 {ECO:0000303|PubMed:15604740};
GN OrderedLocusNames=At3g04570 {ECO:0000312|Araport:AT3G04570};
GN ORFNames=F7O18.4 {ECO:0000312|EMBL:AAF04888.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP IDENTIFICATION, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=15604740; DOI=10.1007/s11103-004-3249-5;
RA Fujimoto S., Matsunaga S., Yonemura M., Uchiyama S., Azuma T., Fukui K.;
RT "Identification of a novel plant MAR DNA binding protein localized on
RT chromosomal surfaces.";
RL Plant Mol. Biol. 56:225-239(2004).
RN [7]
RP FUNCTION.
RX PubMed=20738724; DOI=10.1111/j.1744-7909.2010.00969.x;
RA Lu H., Zou Y., Feng N.;
RT "Overexpression of AHL20 negatively regulates defenses in Arabidopsis.";
RL J. Integr. Plant Biol. 52:801-808(2010).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND INDUCTION BY
RP VERTICILLIUM.
RX PubMed=21864046; DOI=10.1094/mpmi-04-11-0090;
RA Yadeta K.A., Hanemian M., Smit P., Hiemstra J.A., Pereira A., Marco Y.,
RA Thomma B.P.;
RT "The Arabidopsis thaliana DNA-binding protein AHL19 mediates verticillium
RT wilt resistance.";
RL Mol. Plant Microbe Interact. 24:1582-1591(2011).
RN [9]
RP GENE FAMILY, AND DOMAIN PPC.
RX PubMed=24218605; DOI=10.1073/pnas.1219277110;
RA Zhao J., Favero D.S., Peng H., Neff M.M.;
RT "Arabidopsis thaliana AHL family modulates hypocotyl growth redundantly by
RT interacting with each other via the PPC/DUF296 domain.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:E4688-E4697(2013).
CC -!- FUNCTION: Transcription factor that specifically binds AT-rich DNA
CC sequences related to the nuclear matrix attachment regions (MARs) (By
CC similarity). Negatively regulates plant innate immunity (PTI) to
CC pathogens through the down-regulation of the PAMP-triggered FRK1
CC expression (PubMed:20738724). Positively regulates defense against
CC fungal Verticillium infection (PubMed:21864046).
CC {ECO:0000250|UniProtKB:Q8VYJ2, ECO:0000269|PubMed:20738724,
CC ECO:0000269|PubMed:21864046}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VYJ2}.
CC -!- TISSUE SPECIFICITY: Slightly expressed in roots.
CC {ECO:0000269|PubMed:21864046}.
CC -!- INDUCTION: By Verticillium dahlia attack.
CC {ECO:0000269|PubMed:21864046}.
CC -!- DOMAIN: The PPC domain mediates interactions between AHL proteins.
CC {ECO:0000269|PubMed:24218605}.
CC -!- DISRUPTION PHENOTYPE: Enhanced susceptibility to Verticillium wilt
CC resulting in wilting, stunting and chlorosis.
CC {ECO:0000269|PubMed:21864046}.
CC -!- MISCELLANEOUS: Overexpression of AHL19 results in a decreased flg22-
CC induced expression of FRK1 (PubMed:20738724). Overexpression of AHL19
CC results in an increased resistance to Verticillium wilt
CC (PubMed:21864046). {ECO:0000269|PubMed:20738724,
CC ECO:0000269|PubMed:21864046}.
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DR EMBL; AC011437; AAF04888.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74098.1; -; Genomic_DNA.
DR EMBL; BT005882; AAO64817.1; -; mRNA.
DR EMBL; AK228206; BAF00160.1; -; mRNA.
DR EMBL; AY085572; AAM62794.1; -; mRNA.
DR EMBL; BR000355; FAA00290.1; -; mRNA.
DR RefSeq; NP_566232.1; NM_111328.3.
DR AlphaFoldDB; Q9SR17; -.
DR SMR; Q9SR17; -.
DR STRING; 3702.AT3G04570.1; -.
DR MetOSite; Q9SR17; -.
DR PaxDb; Q9SR17; -.
DR PRIDE; Q9SR17; -.
DR ProteomicsDB; 244791; -.
DR EnsemblPlants; AT3G04570.1; AT3G04570.1; AT3G04570.
DR GeneID; 819613; -.
DR Gramene; AT3G04570.1; AT3G04570.1; AT3G04570.
DR KEGG; ath:AT3G04570; -.
DR Araport; AT3G04570; -.
DR TAIR; locus:2084958; AT3G04570.
DR eggNOG; ENOG502QRFG; Eukaryota.
DR HOGENOM; CLU_039808_2_0_1; -.
DR InParanoid; Q9SR17; -.
DR OMA; TGMTIYL; -.
DR OrthoDB; 1334068at2759; -.
DR PhylomeDB; Q9SR17; -.
DR PRO; PR:Q9SR17; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SR17; baseline and differential.
DR Genevisible; Q9SR17; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0003680; F:minor groove of adenine-thymine-rich DNA binding; IBA:GO_Central.
DR GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045824; P:negative regulation of innate immune response; IMP:UniProtKB.
DR CDD; cd11378; DUF296; 1.
DR InterPro; IPR014476; AHL15-29.
DR InterPro; IPR005175; PPC_dom.
DR PANTHER; PTHR31100; PTHR31100; 1.
DR Pfam; PF03479; PCC; 1.
DR PIRSF; PIRSF016021; ESCAROLA; 1.
DR PROSITE; PS51742; PPC; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Immunity; Innate immunity; Nucleus; Plant defense;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..315
FT /note="AT-hook motif nuclear-localized protein 19"
FT /id="PRO_0000432037"
FT DOMAIN 104..248
FT /note="PPC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01078"
FT DNA_BIND 80..92
FT /note="A.T hook"
FT /evidence="ECO:0000305"
FT REGION 1..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..79
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 32038 MW; 1766141EC657C448 CRC64;
MANPWWTGQV NLSGLETTPP GSSQLKKPDL HISMNMAMDS GHNNHHHHQE VDNNNNDDDR
DNLSGDDHEP REGAVEAPTR RPRGRPAGSK NKPKPPIFVT RDSPNALKSH VMEIASGTDV
IETLATFARR RQRGICILSG NGTVANVTLR QPSTAAVAAA PGGAAVLALQ GRFEILSLTG
SFLPGPAPPG STGLTIYLAG GQGQVVGGSV VGPLMAAGPV MLIAATFSNA TYERLPLEEE
EAAERGGGGG SGGVVPGQLG GGGSPLSSGA GGGDGNQGLP VYNMPGNLVS NGGSGGGGQM
SGQEAYGWAQ ARSGF
