ID   EZRA_STAEQ              Reviewed;         564 AA.
AC   Q5HNI8;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=SERP1281;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; CP000029; AAW54684.1; -; Genomic_DNA.
DR   RefSeq; WP_002468056.1; NC_002976.3.
DR   AlphaFoldDB; Q5HNI8; -.
DR   SMR; Q5HNI8; -.
DR   STRING; 176279.SERP1281; -.
DR   EnsemblBacteria; AAW54684; AAW54684; SERP1281.
DR   GeneID; 50018494; -.
DR   KEGG; ser:SERP1281; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_1_0_9; -.
DR   OMA; FRSQNHI; -.
DR   OrthoDB; 670472at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..564
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_0000172885"
FT   TOPO_DOM        1..4
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        5..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        24..564
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          84..126
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          165..223
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          271..303
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          350..435
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   564 AA;  66457 MW;  C98A8265DE81EE30 CRC64;
     MVLFIILAIL VVILIAIGVL FYMRSNKRNL IEKTEERKNE IEQLPLDDNL RKLTGLNLKG
     ETKTKYDAMK KDNTETTNKY LAPVEEKIQN AEELLEKFKF TAAQTEIDDA HELMDQYEEN
     YQHQVTQVDD IINLHKENEA LYEKCKVDYR EMKRDVLANR HQFGEAAEPL ENEIENYEPK
     LNEYENLKSE GNYVQAHNHI AALEDQIKNL KSYMDEIPEL IRETQKELPG QFQDLKYGCR
     DLKVEGYDLD HVKVDGTIQS LKTELSFVEP MISRLELDEA NNKLENINDK LDEMYDLIEY
     EVKAKNEVEE TKDIITDDLF KAKDMNYTLQ TEIEYVRENY YINESDAQSV RQFENEIQSL
     ISVYDDILKE TSKSAVRYSE VQDNLQYLED HVSVINKEQD KLQNHLIQLR EDEAEAEDNL
     LRVQSKKEEV YRRLLASNLT SVPERFIIMK NEIDNEVREV NEQFSERPIH VKQLKDKVAK
     IVIQMNTFED EANDVLVNAV YAEKLIQYGN RYRKDHHHVD KSLNEAERLF KNNRYKRAIE
     IAEEALESVE PGITKHIEEQ VIKE