ID   EZRA_STRMU              Reviewed;         574 AA.
AC   Q8DTQ3;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Septation ring formation regulator EzrA {ECO:0000255|HAMAP-Rule:MF_00728};
GN   Name=ezrA {ECO:0000255|HAMAP-Rule:MF_00728}; OrderedLocusNames=SMU_1276c;
OS   Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=210007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700610 / UA159;
RX   PubMed=12397186; DOI=10.1073/pnas.172501299;
RA   Ajdic D.J., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA   Primeaux C., Tian R., Kenton S., Jia H.G., Lin S.P., Qian Y., Li S.,
RA   Zhu H., Najar F.Z., Lai H., White J., Roe B.A., Ferretti J.J.;
RT   "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT   pathogen.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
CC   -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC       frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC       formation at polar sites. Interacts either with FtsZ or with one of its
CC       binding partners to promote depolymerization. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
CC       Note=Colocalized with FtsZ to the nascent septal site.
CC       {ECO:0000255|HAMAP-Rule:MF_00728}.
CC   -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00728}.
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DR   EMBL; AE014133; AAN58956.1; -; Genomic_DNA.
DR   RefSeq; NP_721650.1; NC_004350.2.
DR   RefSeq; WP_002263873.1; NC_004350.2.
DR   AlphaFoldDB; Q8DTQ3; -.
DR   SMR; Q8DTQ3; -.
DR   STRING; 210007.SMU_1276c; -.
DR   PRIDE; Q8DTQ3; -.
DR   EnsemblBacteria; AAN58956; AAN58956; SMU_1276c.
DR   KEGG; smu:SMU_1276c; -.
DR   PATRIC; fig|210007.7.peg.1144; -.
DR   eggNOG; COG4477; Bacteria.
DR   HOGENOM; CLU_034079_2_0_9; -.
DR   OMA; FRSQNHI; -.
DR   PhylomeDB; Q8DTQ3; -.
DR   Proteomes; UP000002512; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005940; C:septin ring; IEA:InterPro.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR   HAMAP; MF_00728; EzrA; 1.
DR   InterPro; IPR010379; EzrA.
DR   Pfam; PF06160; EzrA; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cell membrane; Coiled coil; Membrane;
KW   Reference proteome; Septation; Transmembrane; Transmembrane helix.
FT   CHAIN           1..574
FT                   /note="Septation ring formation regulator EzrA"
FT                   /id="PRO_0000172888"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TRANSMEM        8..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   TOPO_DOM        27..574
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          102..141
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          255..368
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
FT   COILED          409..495
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00728"
SQ   SEQUENCE   574 AA;  66584 MW;  8327B6AD8612DB85 CRC64;
     MSSGIVLLIV AIVLVVIIAY LIAIIIRKRN DSLITKLEER KQNLFDLPVN DEIEEVKKLH
     LIGQSQTTFR EWNQKWVDLS LNSFSDIENH IFEAENLNDT FNFIRAHSQI NNIESQLNLA
     EEDIKAIREA LAVLKEQEEK NSARVLHALE MYESLQASIE EGDSNFGITM PEIEKQLKNI
     EAEFSQFVTL NSSGDPVEAS EILDRAEEHT IALGQMTEKI PAIVAKLEDD FPDQLDDLES
     GYRRLLEENY HFPEKNIEER FQEVREAIGN NSNELVSLDL DKAESENEAI QEKIDSLYDI
     FEREIRAHKN IVKSKKIIPA YLEHAKKNNE QLEAEIERLN HRYILNEKEE LNVRDFNEEI
     ASVEKDVLPI IENFDTQEKP FSVLEDKFDR AIKKLDLVEE GQLDVFNSLK NIENVEKTAR
     QKLDSYINRL HAIKRFMEKR NLPGIPQDFL SVFFTTSAQL EALMDELNRA RIHIETVNRM
     TEAATAAVEN LEETAYRVVQ NATLTEQLLQ YSNRYRSFEP SVQESFDIAL KLFETDYDYQ
     GSFDEISYSL ETVEPGVTDR FVSSYEKTRE TIRF